2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Polyinosinic acid sodium

Polyinosinic acid sodium is the sodium form of Polyinosinic acid (HY-148980). Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation.

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Polyinosinic acid sodium Chemical Structure

Polyinosinic acid sodium Chemical Structure

CAS No. : 33378-44-8

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Description

Polyinosinic acid sodium is the sodium form of Polyinosinic acid (HY-148980). Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation[1].

Formula

(C10H13N4O8P)x.xNa
CAS No.
Appearance

Solid

SMILES

O=P(O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=C(C(N=CN3)=O)N=C2)O1.[x].[Na].[x]
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Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Polyinosinic acid sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polyinosinic acid33378-44-8Toll-like Receptor (TLR)BALB/c B cellsBALB/c BMDC cellsTRIF+/+TLR3+/+CD86CD40IFNIFNαThymidineInhibitorinhibitorinhibit

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Polyinosinic acid sodium
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HY-148980A
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