PROTAC AAK1 degrader-1

Cat. No.: HY-181293: Ficha de datos Instrucciones de manejo
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PROTAC AAK1 degrader-1 (compound 14) is a selective PROTAC AAK1 degrader with a DC₅₀ of <10 nM. PROTAC AAK1 degrader-1 does not significantly impact the levels of any other NAK family members, including BMP2K, GAK, and STK16. PROTAC AAK1 degrader-1 can be used in ovarian cancer research.

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PROTAC AAK1 degrader-1 Estructura química

No. CAS : 3113123-63-7

Tamaño	Stock	Cantidad
10 mg	Obtener un presupuesto 5 - 7 weeks 4 - 6 weeks 6 - 8 weeks 4 - 6 weeks	Estimated Time of Arrival: December 31
25 mg	Obtener un presupuesto 5 - 7 weeks 4 - 6 weeks 6 - 8 weeks 4 - 6 weeks	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto 5 - 7 weeks 4 - 6 weeks 6 - 8 weeks 4 - 6 weeks	Estimated Time of Arrival: December 31
100 mg	Obtener un presupuesto
200 mg	Obtener un presupuesto

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Descripciòn	PROTAC AAK1 degrader-1 (compound 14) is a selective PROTAC AAK1 degrader with a DC₅₀ of <10 nM. PROTAC AAK1 degrader-1 does not significantly impact the levels of any other NAK family members, including BMP2K, GAK, and STK16. PROTAC AAK1 degrader-1 can be used in ovarian cancer research^[1].
In Vitro	PROTAC AAK1 Degrader-1 (1-100 nM, 1-24 h)’s effect on AAK1 protein levels is rapid, noticeable within one hour, and lasted for 3-4 days after 4-hour 14 treatment followed by extensive drug wash-off. PROTAC AAK1 Degrader-1 is also effective in reducing AAK1 levels in a panel of ovarian cancer cell lines including Taxane-resistant sublines (A2780- R and HEY-R) as well as various other cancer types^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. PROTAC AAK1 degrader-1 Related Antibodies
Peso molecular	852.00
Fòrmula	C₄₈H₅₆F₃N₇O₄
No. CAS	3113123-63-7
SMILES	CC(C[C@@H](COC1=CC=C(C=C1C(F)(F)F)C2=CC(NC3=CC=C(C=C3)C4CCN(CC4)CC5CCN(CC5)C6=CC7=C(C(N(C7)C8CCC(NC8=O)=O)=O)C=C6)=NC=C2)N)C
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (262 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Guangrong Zheng, et al. WO2026011086A1. 2025.