2. Recombinant Proteins
  3. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  4. FGF Family Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. FGFR

FGFR

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Fibroblast growth factor receptors (FGFRs) are receptor tyrosine kinase members expressed on the cell membrane that are involved in a variety of biological processes, including cell growth, migration, differentiation, survival, and apoptosis, and are essential for embryonic and neural development, skeletal and organ formation, and adult tissue homoeostasis. As their name implies, FGFRs bind to members of the fibroblast growth factor family of proteins, mediating signal transduction. FGFRs are made of N-terminal extracellular domains with three different immunoglobulin-like subdomains (D1, D2 and D3), a transmembrane domain and a cytoplasmic tyrosine kinase domain. In humans, six FGFR family members are currently identified (FGFR1-6). Among them, FGFR5 (also known as “FGFRL1”) is a truncated FGFR without intracellular kinase domain and plays a role in regulating excessive activation of the FGF-FGFR1 signaling pathway. Binding of ligand triggers functional dimerization and transphosphorylation of FGFRs, activation of four key downstream signalling pathways: RAS-RAF-MAPK, PI3K-AKT, STAT and PLCγ. FGF/FGFR signaling participates in the development of almost all organs such as lung, heart, urinary system, brain, skeleton, muscle, and skin/appendage, as well as angiogenesis and lymphangiogenesis. The malfunction of FGF/FGFR signaling axis is observed in a variety of human diseases, such as congenital craniosynostosis and dwarfism syndromes, as well as chronic kidney disease (CKD), obesity, insulin resistance, and various tumors.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P73057
    FGFR-4 Protein, Human (HEK293, Fc)

    Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF

    		Human HEK293
    The leptin R/LEPR protein is a receptor protein that binds to the hormone leptin. It plays a vital role in regulating energy balance and body weight. FGFR-4 Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-4 Protein, Human (HEK293, Fc) is 348 a.a., with molecular weight of 95-112 kDa.
  • HY-P73059
    FGFR-4 Protein, Human (HEK293, His)

    Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF

    		Human HEK293
    The FGFR-4 protein is a tyrosine protein kinase and cell surface receptor for fibroblast growth factor that regulates diverse cellular processes such as proliferation, differentiation, migration, lipid metabolism, and bile acid biosynthesis. Notably, it contributes to the downregulation of the bile acid synthase CYP7A1 in response to FGF19. FGFR-4 Protein, Human (HEK293, His) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-4 Protein, Human (HEK293, His) is 369 a.a., with molecular weight of ~60 kDa.
  • HY-P76336
    FGFR-2 alpha IIIb Protein, Human (HEK293, His)

    Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK

    		Human HEK293
    The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIb Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-2 alpha IIIb Protein, Human (HEK293, His) is 357 a.a., with molecular weight of 60-80 KDa.
  • HY-P76337
    FGFR-2 alpha IIIc Protein, Human (HEK293, His)

    Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK

    		Human HEK293
    The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIc Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-2 alpha IIIc Protein, Human (HEK293, His) is 356 a.a., with molecular weight of 60-80 KDa.
  • HY-P77659
    FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi)

    FGF R1a; FGFR1 alpha

    		Human HEK293
    FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is 353 a.a., with molecular weight of 65-85 kDa.
  • HY-P77660
    FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi)

    FGF R1a; FGFR1 alpha

    		Human HEK293
    FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is 353 a.a., with molecular weight of 68-80 kDa.
  • HY-P78439
    FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi)

    ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4

    		Human HEK293
    The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) is 353 a.a., with molecular weight of 65-75 kDa.
  • HY-P73054
    FGFR-1 beta Protein, Human (HEK293, His-Fc)

    Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; CEK; FGFBR, FLG

    		Human HEK293
    FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta Protein, Human (HEK293, His-Fc) is the recombinant human-derived FGFR-1 beta protein, expressed by HEK293 , with C-8*His, C-hFc labeled tag. The total length of FGFR-1 beta Protein, Human (HEK293, His-Fc) is 264 a.a., with molecular weight of 100-110 kDa.
  • HY-P70817
    FGFR-3 Protein, Human (HEK293, Fc)

    Fibroblast growth factor receptor 3; FGFR-3; CD333; FGFR3; JTK4; IIIc

    		Human HEK293
    The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-3 Protein, Human (HEK293, Fc) is 353 a.a., with molecular weight of 95-110 kDa.
  • HY-P72644
    FGFR-3 Protein, Human (HEK293, His)

    Fibroblast growth factor receptor 3; FGFR-3; CD333; JTK4

    		Human HEK293
    The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (HEK293, His) is the recombinant human-derived FGFR-3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGFR-3 Protein, Human (HEK293, His) is 353 a.a., with molecular weight of 60-75 kDa.
  • HY-P73055
    FGFR-1 beta Protein, Human (HEK293, His)

    Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; CEK; FGFBR, FLG

    		Human HEK293
  • HY-P73061
    FGFR-4 Protein, Rat (HEK293, Fc, Solution)

    Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF

    		Rat HEK293
    The FGFR-4 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that regulates cellular processes, lipid metabolism, bile acid biosynthesis, and more. Its effects include downregulation of CYP7A1 in response to FGF19. FGFR-4 Protein, Rat (HEK293, Fc, Solution) is the recombinant rat-derived FGFR-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-4 Protein, Rat (HEK293, Fc, Solution) is 351 a.a., with molecular weight of ~110 kDa.
  • HY-P74153
    FGFR-3 Protein, Mouse (HEK293, His)

    Fibroblast growth factor receptor 3; FGFR-3; CD333; Mfr3; Sam3

    		Mouse HEK293
    The FGFR-3 protein is a tyrosine protein kinase that serves as a cell surface receptor for fibroblast growth factors and controls cellular processes, including proliferation, differentiation, and apoptosis. It is essential for chondrocyte differentiation, proliferation, apoptosis and normal bone development functions. FGFR-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-3 Protein, Mouse (HEK293, His) is 347 a.a., with molecular weight of 60-90 kDa.
  • HY-P77654
    FGFR-1 beta (IIIc) Protein, Human (HEK293, His-Avi)

    Fibroblast growth factor receptor 1; FGFR-1; BFGFR; bFGF-R-1; FLT-2; CD331;

    		Human HEK293
    FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 beta (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-1 beta, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 beta (IIIc) Protein, Human (HEK293, His-Avi) is 198 a.a., with molecular weight of 50-55 kDa.
  • HY-P73061A
    FGFR-4 Protein, Rat (HEK293, C-hFc)

    Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF

    		Rat HEK293
    The FGFR-4 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that regulates cellular processes, lipid metabolism, bile acid biosynthesis, and more. Its effects include downregulation of CYP7A1 in response to FGF19. FGFR-4 Protein, Rat (HEK293, C-hFc) is the recombinant rat-derived FGFR-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-4 Protein, Rat (HEK293, C-hFc) is 351 a.a., with molecular weight of ~110 kDa.
  • HY-P72196
    FGFR-3 Protein, Human (His-B2M)

    ACH; CD 333; CD333; CD333 antigen; CEK 2; CEK2; FGFR 3; FGFR-3; FGFR3; FGFR3_HUMAN; Fibroblast growth factor receptor 3 achondroplasia thanatophoric dwarfism; ; Fibroblast growth factor receptor 3; Heparin binding growth factor receptor; HSFGFR3EX; Hydroxyaryl protein kinase; JTK 4; JTK4; MFR 3; SAM 3; Tyrosine kinase JTK 4; Tyrosine kinase JTK4; Z FGFR 3

    		Human E. coli
    The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (His-B2M) is the recombinant human-derived FGFR-3 protein, expressed by E. coli , with N-6*His, N-B2M labeled tag. The total length of FGFR-3 Protein, Human (His-B2M) is 410 a.a., with molecular weight of ~59.4 kDa.
  • HY-P72645
    FGFR-2 alpha IIIc Protein, Human (HEK293, Fc)

    BEK, FGFR2IIIc; CD332; FGF R2b; FGFR2 beta; FGFR2; FGFR2b;  Fibroblast growth factor receptor 2 (IIIc)

    		Human HEK293
    The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIc Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-2 alpha IIIc Protein, Human (HEK293, Fc) is 356 a.a., with molecular weight of 85-120 kDa.
  • HY-P76343
    FGFRL1 Protein, Mouse (HEK293, His)

    Fibroblast growth factor receptor-like 1; FGFR-5; FGFRL1; FGFR5; FHFR

    		Mouse HEK293
    FGFRL1 protein significantly inhibits cell proliferation by interacting with FGF2 with low affinity, thereby regulating the proliferative signals associated with FGF2. This unique property positions FGFRL1 as a modulator of cellular growth, highlighting its intricate involvement in maintaining cellular homeostasis. FGFRL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFRL1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFRL1 Protein, Mouse (HEK293, His) is 354 a.a., with molecular weight of ~55-68 KDa.
  • HY-P78131
    FGFR-2 alpha IIIc Protein, Human (Biotinylated, HEK293, His-Avi)

    FGF R2a; FGFR2 alpha; KGFR; CD332; BBDS; BEK; BFR-1; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25; FLJ98662

    		Human HEK293
    The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIc Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of FGFR-2 alpha IIIc Protein, Human (Biotinylated, HEK293, His-Avi) is 356 a.a., with molecular weight of 70-80 kDa.
  • HY-P75191
    FGFR-4 Protein, Mouse (HEK293, His)

    Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF

    		Mouse HEK293
    FGFR-4 protein is a tyrosine protein kinase that serves as a cell surface receptor for fibroblast growth factor and controls proliferation, differentiation, migration, lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism, and phosphate and other cellular processes homeostasis. It significantly downregulates CYP7A1 in response to FGF19. FGFR-4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-4 Protein, Mouse (HEK293, His) is 196 a.a., with molecular weight of 58-80 kDa.
Cat. No. Product Name Effect Purity