RP-001 hydrochloride

Name: RP-001 hydrochloride
Brand: MedChemExpress
SKU: HY-101939A
Rating: 4.5 (0 reviews)

製品番号: HY-101939A 純度: 98.8%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC₅₀ of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

RP-001 hydrochloride 構造式

CAS 番号 : 1781880-34-9

容量	価格（税別）	在庫状況	数量
1 mg	$86	在庫あり	Estimated Time of Arrival: December 31
5 mg		お問い合わせ
10 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of RP-001 hydrochloride:

RP-001 お問い合わせ

LPL Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

RP-001 hydrochloride elicits dose-dependent lymphopenia of CD4⁺ T cells. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

RP-001 hydrochloride causes dose-dependent rapid lymphopenia with an EC₅₀ of 0.03 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

468.93

分子式

C₂₄H₂₅ClN₄O₄

CAS 番号

1781880-34-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCNC1CCC2=C1C=CC=C2C3=NOC(C4=CC=C(OC(C)C)C(C#N)=C4)=N3.Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 29.4 mg/mL (62.70 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1325 mL	10.6626 mL	21.3251 mL
5 mM	0.4265 mL	2.1325 mL	4.2650 mL
10 mM	0.2133 mL	1.0663 mL	2.1325 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.8%

Select Batch:

データシート (273 KB) SDS (252 KB)

COA (254 KB) Elemental Analysis Report (112 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Cahalan SM, et al. Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat Chem Biol. 2011 May;7(5):254-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1325 mL	10.6626 mL	21.3251 mL	53.3129 mL
	5 mM	0.4265 mL	2.1325 mL	4.2650 mL	10.6626 mL
	10 mM	0.2133 mL	1.0663 mL	2.1325 mL	5.3313 mL
	15 mM	0.1422 mL	0.7108 mL	1.4217 mL	3.5542 mL
	20 mM	0.1066 mL	0.5331 mL	1.0663 mL	2.6656 mL
	25 mM	0.0853 mL	0.4265 mL	0.8530 mL	2.1325 mL
	30 mM	0.0711 mL	0.3554 mL	0.7108 mL	1.7771 mL
	40 mM	0.0533 mL	0.2666 mL	0.5331 mL	1.3328 mL
	50 mM	0.0427 mL	0.2133 mL	0.4265 mL	1.0663 mL
	60 mM	0.0355 mL	0.1777 mL	0.3554 mL	0.8885 mL