(S,R,S)-AHPC(Me)-amido-C2-acid

Cat. No.: HY-164043 Purity: 95.05%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(S,R,S)-AHPC(Me)-amido-C2-acid is an VHL (E3 ligase) ligand, and can be used for synthesis of PROTACs, such as PROTAC STING Degrader-2 (HY-158036).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

(S,R,S)-AHPC(Me)-amido-C2-acid 화학구조

CAS No. : 2365173-01-7

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기	Estimated Time of Arrival: December 31
100 mg	견적 받기	Estimated Time of Arrival: December 31
250 mg	견적 받기	Estimated Time of Arrival: December 31
500 mg	견적 받기
1 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

Biological Activity
순도&문서
References
고객리뷰

제품 설명

(S,R,S)-AHPC(Me)-amido-C2-acid is an VHL (E3 ligase) ligand, and can be used for synthesis of PROTACs, such as PROTAC STING Degrader-2 (HY-158036)^[1].

IC₅₀ & Target

VHL

분자량

544.66

화학식

C₂₇H₃₆N₄O₆S

CAS No.

2365173-01-7

Appearance

Solid

Color

White to off-white

SMILES

OC(CCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 25 mg/mL (45.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8360 mL	9.1800 mL	18.3601 mL
5 mM	0.3672 mL	1.8360 mL	3.6720 mL
10 mM	0.1836 mL	0.9180 mL	1.8360 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 95.05%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (260 KB) HNMR (294 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Nakamura M, et al. Development of STING degrader with double covalent ligands[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129677. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8360 mL	9.1800 mL	18.3601 mL	45.9002 mL
	5 mM	0.3672 mL	1.8360 mL	3.6720 mL	9.1800 mL
	10 mM	0.1836 mL	0.9180 mL	1.8360 mL	4.5900 mL
	15 mM	0.1224 mL	0.6120 mL	1.2240 mL	3.0600 mL
	20 mM	0.0918 mL	0.4590 mL	0.9180 mL	2.2950 mL
	25 mM	0.0734 mL	0.3672 mL	0.7344 mL	1.8360 mL
	30 mM	0.0612 mL	0.3060 mL	0.6120 mL	1.5300 mL
	40 mM	0.0459 mL	0.2295 mL	0.4590 mL	1.1475 mL