2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. SCH-23390

SCH-23390 is a dopamine D1-like receptor antagonist (with Ki values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline (HY-B0726A) and strychnine, and is used in research on neurological disorders related to the dopamine system.

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CAS 番号 : 87075-17-0

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SCH-23390 関連抗体

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    SCH-23390 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590.  [Abstract]

    SCH23390 (10 μM, 2 h) decreased the association between Sig1R and BiP by Co-IP.

    SCH-23390 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590.  [Abstract]

    We detected increased translocation of Sig1R to plasma membrane in SH-SY5Y cells treated with SCH23390 (10 μM, 2 h).

    SCH-23390 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590.  [Abstract]

    Primary neurons from WT and Sig1R KO mice were pre-treated with SCH23390 (10 μM) or SKF10047 (0.5 or 5 μM) for 30 min prior to and during treatment with MPP+ (800 μM). After incubation for 24 h, cells were fixed and subjected to immunostaining with an anti-MAP2 antibody (1:2000) as described, followed by double-staining with TUNEL (red) and Hoechst (blue). SCH23390 synergistically promotes the neuroprotective effect of the Sig1R agonist, SKF10047.

    SCH-23390 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941.   [Abstract]

    GSH levels in astrocytes treated with 10 μM cabergoline for 12 h after pretreatment with SCH23390 (10 μM) or sulpiride (10 μM).

    SCH-23390 purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120.  [Abstract]

    SCH23390 (0.05, 0.1, 0.2 μg/mouse) induced decreased social behavior in C57BL/6J mice.

    Dopamine Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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    製品説明

    SCH-23390 is a dopamine D1-like receptor antagonist (with Ki values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline (HY-B0726A) and strychnine, and is used in research on neurological disorders related to the dopamine system[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    CHO IC50
    1.4 nM
    Compound: R(+)-SCH-23390
    Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs
    Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs
    		[PMID: 23403082]
    HEK293 IC50
    2.52 nM
    Compound: 1, SCH23390
    Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells
    Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells
    		[PMID: 22748706]
    分子量

    287.78

    分子式

    C17H18ClNO
    CAS 番号
    SMILES

    OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    純度とドキュメンテーション
    参考文献
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    SCH-23390 Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SCH-2339087075-17-0R-(+)-SCH-23390SCH23390SCH 23390Dopamine Receptorcocaineratlever pressing behaviorInhibitorinhibitorinhibit

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    製品名:
    SCH-23390
    製品番号:
    HY-19545
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