Scyllo-Inositol  (Synonyms: scyllo-イノシトール)

Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease^[1][2][3].

Scyllo-Inositol (1:1 (w/v%) mixture; 1-21 d) inhibits fibril formation of human and mouse α-synuclein and was more potent than chiro-inositol (HY-N3021)^[1].
Scyllo-Inositol (1-100 μM; 24 h) dose-dependently reduces polyQ-Htt protein levels and misfolded protein aggregates in PC12 cells. Scyllo-Inositol also activates the proteasome and lysosomal degradation pathways without affecting the levels of autophagy markers (LC3, p62)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Scyllo-Inositol (16.5 mg/L drinking water; for 2 months) significantly increases Scyllo-Inositol concentrations in the hippocampus (2.4-fold) and prefrontal cortex (2.2-fold) of APP×PS1 and APP×PS1×tau transgenic mouse models, which associated with increased glutamine levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

180.16

C₆H₁₂O₆

488-59-5

Solid

White to off-white

O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1O)O)O)O)O

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Ibrahim T, et al. α-Synuclein aggregation, seeding and inhibition by scyllo-inositol. Biochem Biophys Res Commun. 2016 Jan 15;469(3):529-34.  [Content Brief]

  [2]. Lai AY, et al. scyllo-Inositol promotes robust mutant Huntingtin protein degradation. J Biol Chem. 2014 Feb 7;289(6):3666-76.  [Content Brief]

  [3]. Choi JK, et al. Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models. Neuropharmacology. 2010 Sep-Oct;59(4-5):353-7.  [Content Brief]