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β-oxidation metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (5) Endogenous Metabolite (11) Akt (2) Aryl Hydrocarbon Receptor (1) ERK (2) Isotope-Labeled Compounds (2) Na+/K+ ATPase (1) p38 MAPK (2) PKA (2) PPAR (2) Prostaglandin Receptor (2) Reference Standards (3)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (1) Metabolic Disease (18)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Endogenous Metabolite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113261

Oleoylcarnitine	Endogenous Metabolite	Metabolic Disease Cancer
Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-N2118

Bilobetin 2 Publications Verification	PPAR PKA Akt p38 MAPK ERK	Metabolic Disease
Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-W012974

3-Aminoisobutyric acid β-Aminoisobutyric acid; BAIBA	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
3-Aminoisobutyric acid (β-Aminoisobutyric acid) has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid is a catabolic metabolite of thymine and valine in skeletal muscle .

HY-113158

4-Hydroxyhippuric acid	Drug Metabolite	Metabolic Disease
4-Hydroxyhippuric acid is a metabolite of polyphenols. 4-Hydroxyhippuric acid is generated via medium-chain acyl-CoA dehydrogenase (MCAD)-dependent β-oxidation of microbially-produced 3-(4-hydroxyphenyl)propionic acid, followed by host glycine conjugation. 4-Hydroxyhippuric acid can be simultaneously detected in urine as a biomarker of dietary polyphenol intake .

HY-113304

(S)-3,4-Dihydroxybutyric acid	Endogenous Metabolite	Metabolic Disease
(S)-3,4-Dihydroxybutyric acid, a normal human urinary metabolite, is a β-oxidation metabolite of γ-hydroxybutyrate. (S)-3,4-Dihydroxybutyric acid can be used for research on succinic semialdehyde dehydrogenase deficiency .

HY-113304A

(S)-3,4-Dihydroxybutyric acid lithium hydrate	Endogenous Metabolite	Metabolic Disease
(S)-3,4-Dihydroxybutyric acid lithium hydrate, a normal human urinary metabolite, is a β-oxidation metabolite of γ-hydroxybutyrate. (S)-3,4-Dihydroxybutyric acid lithium hydrate can be used for research on succinic semialdehyde dehydrogenase deficiency .

HY-124404

12(R)-HETE	Aryl Hydrocarbon Receptor Na+/K+ ATPase Prostaglandin Receptor	Inflammation/Immunology
12(R)-HETE is a CYP-dependent arachidonic acid metabolite that acts as a proinflammatory lipid mediator. 12 (R)-HETE widely exists in various tissues including the eye, skin and liver. In the cornea, 12(R)-HETE is metabolized via pathways such as β-oxidation into the precursor of 12(R)-HETrE. Without direct receptor binding, 12(R)-HETE indirectly activates AHR-mediated target gene transcription, while inhibiting the enzymatic activity of Na+,K+-ATPase and the intracellular calcium elevation induced by TP agonists. 12(R)-HETE also possesses multiple physiological effects such as chemotaxis, proangiogenesis, vasodilation, natriuresis, diuresis and intraocular pressure reduction, and can be widely used in studies related to psoriasis, inflammatory skin diseases and ocular inflammation .

HY-113261S

Oleoylcarnitine-d9	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Cancer
Oleoylcarnitine-d₉ is deuterium labeled Oleoylcarnitine. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-137555

11-dehydro-2,3-dinor Thromboxane B2 11-dehydro-2,3-dinor TXB2	Endogenous Metabolite	Metabolic Disease
11-dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite of the TXA2 inactive metabolite TXB2 (Item No. 19030). It is formed from TXB2 by cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation. Levels of 11-dehydro-2,3-dinor TXB2 are increased 5.2-fold in a surgery-induced rat model of tendon overuse.

HY-W353470

2,3-Dinor-8-iso prostaglandin F 2α 2,3-Dinor-8-isoPGF2α	Drug Metabolite	Metabolic Disease
2,3-Dinor-8-iso prostaglandin F₂α (2,3-Dinor-8-isoPGF2α) is the major β-oxidation metabolite of 8-iso-prostaglandin F₂α. 2,3-Dinor-8-iso prostaglandin F₂α serves as a biomarker to evaluate the in vivo production of 8-iso-prostaglandin F₂α and the level of lipid peroxidation. 2,3-Dinor-8-iso prostaglandin F₂α is promising for research of oxidative stress-related diseases such as arteriosclerosis and diabetes .

HY-120556

tetranor-12(R)-HETE 8(R)-HHxTrE; tetranor-12(R)-Hydroxyeicosatetraenoic acid; 2,3,4,5-Tetranor 12(R)-HETE	Drug Metabolite	Metabolic Disease
tetranor-12(R)-HETE is a metabolite of 12(R)-HETE formed via β-oxidation.

HY-113879

18-Carboxy dinor Leukotriene B4 18-Carboxy dinor LTB4	Drug Metabolite	Metabolic Disease
18-Carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4. In the liver, LTB4 is rapidly metabolized to 20-carboxy LTB4, which then undergoes β-oxidation to 18-carboxy dinor LTB4.

HY-168397

tetranor-Prostaglandin E1	Prostaglandin Receptor	Endocrinology
tetranor-Prostaglandin E1 is metabolite of Prostaglandin E1 (HY-B0131) and Prostaglandin E2 (HY-101952) that is formed by β-oxidation .

HY-113261R

Oleoylcarnitine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease Cancer
Oleoylcarnitine (Standard) is the analytical standard of Oleoylcarnitine. This product is intended for research and analytical applications. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-165098

3-Aminoisobutyric acid sodium salt β-Aminoisobutyric acid sodium salt; BAIBA sodium salt	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
3-Aminoisobutyric acid (β-Aminoisobutyric acid) sodium salt has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid sodium salt increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid sodium salt attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid sodium salt is a catabolic metabolite of thymine and valine in skeletal muscle .

HY-113158R

4-Hydroxyhippuric acid (Standard)	Reference Standards Drug Metabolite	Metabolic Disease
4-Hydroxyhippuric acid (Standard) is the analytical standard of 4-Hydroxyhippuric acid (HY-113158). This product is intended for research and analytical applications. 4-Hydroxyhippuric acid is a metabolite of polyphenols. 4-Hydroxyhippuric acid is generated via medium-chain acyl-CoA dehydrogenase (MCAD)-dependent β-oxidation of microbially-produced 3-(4-hydroxyphenyl)propionic acid, followed by host glycine conjugation. 4-Hydroxyhippuric acid can be simultaneously detected in urine as a biomarker of dietary polyphenol intake .

HY-N2118R

Bilobetin (Standard)	Reference Standards PPAR PKA Akt p38 MAPK ERK	Metabolic Disease
Bilobetin (Standard) is the analytical standard of Bilobetin. This product is intended for research and analytical applications. Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-W400421

3-Hydroxyvalproic acid 3-Hydroxy VPA	Endogenous Metabolite	Metabolic Disease
3-Hydroxyvalproic acid (3-Hydroxy VPA) is a metabolite of valproic acid. 3-Hydroxyvalproic acid is a weak inhibitor of enzymes related to the mitochondrial β-oxidation pathway. 3-Hydroxyvalproic acid is promising for research of diseases related to abnormal valproic acid metabolism .

HY-113261S1

Oleoylcarnitine-13C,d3	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Cancer
Oleoylcarnitine- ¹³C,d₃ is the deuterium and ¹³C-labeled Oleoylcarnitine (HY-113261). Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-N7388

3-Hydroxy-2-methylbutanoic acid	Endogenous Metabolite	Metabolic Disease
3-Hydroxy-2-methylbutanoic acid is a short-chain carboxylic acid and a normal urinary metabolite produced via isoleucine catabolism, fatty acid β-oxidation and ketogenesis. 3-Hydroxy-2-methylbutanoic acid exists as an acylated residue in resin glycosides derived from plants of the Ipomoea genus. 3-Hydroxy-2-methylbutanoic acid can be used in studies related to β-ketothiolase deficiency .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113261

Oleoylcarnitine	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-N2118

Bilobetin 2 Publications Verification	Flavonoids Ginkgoaceae Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Biflavones Ginkgo biloba Disease Research Fields Source Classification	PPAR PKA Akt p38 MAPK ERK
Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-W012974

3-Aminoisobutyric acid β-Aminoisobutyric acid; BAIBA	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-Aminoisobutyric acid (β-Aminoisobutyric acid) has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid is a catabolic metabolite of thymine and valine in skeletal muscle .

HY-113158

4-Hydroxyhippuric acid	Immune System Disorder Disease markers Endogenous metabolite	Drug Metabolite
4-Hydroxyhippuric acid is a metabolite of polyphenols. 4-Hydroxyhippuric acid is generated via medium-chain acyl-CoA dehydrogenase (MCAD)-dependent β-oxidation of microbially-produced 3-(4-hydroxyphenyl)propionic acid, followed by host glycine conjugation. 4-Hydroxyhippuric acid can be simultaneously detected in urine as a biomarker of dietary polyphenol intake .

HY-113304

(S)-3,4-Dihydroxybutyric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
(S)-3,4-Dihydroxybutyric acid, a normal human urinary metabolite, is a β-oxidation metabolite of γ-hydroxybutyrate. (S)-3,4-Dihydroxybutyric acid can be used for research on succinic semialdehyde dehydrogenase deficiency .

HY-113304A

(S)-3,4-Dihydroxybutyric acid lithium hydrate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
(S)-3,4-Dihydroxybutyric acid lithium hydrate, a normal human urinary metabolite, is a β-oxidation metabolite of γ-hydroxybutyrate. (S)-3,4-Dihydroxybutyric acid lithium hydrate can be used for research on succinic semialdehyde dehydrogenase deficiency .

HY-113261R

Oleoylcarnitine (Standard)	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Reference Standards Endogenous Metabolite
Oleoylcarnitine (Standard) is the analytical standard of Oleoylcarnitine. This product is intended for research and analytical applications. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-113158R

4-Hydroxyhippuric acid (Standard)	Immune System Disorder Disease markers Endogenous metabolite	Reference Standards Drug Metabolite
4-Hydroxyhippuric acid (Standard) is the analytical standard of 4-Hydroxyhippuric acid (HY-113158). This product is intended for research and analytical applications. 4-Hydroxyhippuric acid is a metabolite of polyphenols. 4-Hydroxyhippuric acid is generated via medium-chain acyl-CoA dehydrogenase (MCAD)-dependent β-oxidation of microbially-produced 3-(4-hydroxyphenyl)propionic acid, followed by host glycine conjugation. 4-Hydroxyhippuric acid can be simultaneously detected in urine as a biomarker of dietary polyphenol intake .

HY-N2118R

Bilobetin (Standard)	Structural Classification Flavonoids Ginkgoaceae Phenols Polyphenols Plants Biflavones Ginkgo biloba Source Classification	Reference Standards PPAR PKA Akt p38 MAPK ERK
Bilobetin (Standard) is the analytical standard of Bilobetin. This product is intended for research and analytical applications. Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-N7388

3-Hydroxy-2-methylbutanoic acid	Structural Classification Endogenous metabolite Lipid Source Classification	Endogenous Metabolite
3-Hydroxy-2-methylbutanoic acid is a short-chain carboxylic acid and a normal urinary metabolite produced via isoleucine catabolism, fatty acid β-oxidation and ketogenesis. 3-Hydroxy-2-methylbutanoic acid exists as an acylated residue in resin glycosides derived from plants of the Ipomoea genus. 3-Hydroxy-2-methylbutanoic acid can be used in studies related to β-ketothiolase deficiency .

Cat. No.	Product Name	Chemical Structure

HY-113261S

Oleoylcarnitine-d9
Oleoylcarnitine-d₉ is deuterium labeled Oleoylcarnitine. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-113261S1

Oleoylcarnitine-13C,d3
Oleoylcarnitine- ¹³C,d₃ is the deuterium and ¹³C-labeled Oleoylcarnitine (HY-113261). Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

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β-oxidation metabolite

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products