3-Aminoisobutyric acid
Based on 1 Customer Validation
3-Aminoisobutyric acid (β-Aminoisobutyric acid) has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid is a catabolic metabolite of thymine and valine in skeletal muscle.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 144-90-1
- Formula: C4H9NO2
- Molecular Weight:103.12
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Solvent & Solubility
- Protocol
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- References
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Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 144-90-1
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Appearance Solid
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Molecular Weight 103.12
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Formula C4H9NO2
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Color White to off-white
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SMILES
CC(C(O)=O)CN
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Synonyms
β-Aminoisobutyric acid; BAIBA
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
H2O : 100 mg/mL (969.74 mM; Need ultrasonic)
DMSO : 1 mg/mL (9.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (969.74 mM); Clear solution; Need ultrasonic
Protocol
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Roberts LD, et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 7;19(1):96-108. [Content Brief]
[2]. Jung TW, et al. BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARδ-dependent pathway in mice. Diabetologia. 2015 Sep;58(9):2096-105. [Content Brief]
[3]. Audzeyenka I, et al. β-Aminoisobutyric acid (L-BAIBA) is a novel regulator of mitochondrial biogenesis and respiratory function in human podocytes. Sci Rep. 2023 Jan 14;13(1):766. [Content Brief]
[4]. Yi X, et al. Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill. Front Endocrinol (Lausanne). 2023 May 29;14:1192458. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 9.6974 mL | 48.4872 mL | 96.9744 mL | 242.4360 mL |
| 5 mM | 1.9395 mL | 9.6974 mL | 19.3949 mL | 48.4872 mL | |
| H2O | 10 mM | 0.9697 mL | 4.8487 mL | 9.6974 mL | 24.2436 mL |
| 15 mM | 0.6465 mL | 3.2325 mL | 6.4650 mL | 16.1624 mL | |
| 20 mM | 0.4849 mL | 2.4244 mL | 4.8487 mL | 12.1218 mL | |
| 25 mM | 0.3879 mL | 1.9395 mL | 3.8790 mL | 9.6974 mL | |
| 30 mM | 0.3232 mL | 1.6162 mL | 3.2325 mL | 8.0812 mL | |
| 40 mM | 0.2424 mL | 1.2122 mL | 2.4244 mL | 6.0609 mL | |
| 50 mM | 0.1939 mL | 0.9697 mL | 1.9395 mL | 4.8487 mL | |
| 60 mM | 0.1616 mL | 0.8081 mL | 1.6162 mL | 4.0406 mL | |
| 80 mM | 0.1212 mL | 0.6061 mL | 1.2122 mL | 3.0304 mL | |
| 100 mM | 0.0970 mL | 0.4849 mL | 0.9697 mL | 2.4244 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
3-Aminoisobutyric acid Related Classifications
HY-W012974 Related Classifications
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