AQP1

標的別:	Aquaporin (7) Akt (2) Apoptosis (5) Cadherin (1) Caspase (1) Drug Metabolite (1) Monoamine Oxidase (2) PI3K (2) PKC (2) Pregnane X Receptor (PXR) (2) Reference Standards (3) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (1)
研究分野別:	Cancer (5) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: Aquaporin

製品番号	製品名	Target	研究分野	構造式

HY-174166

AqF026	Aquaporin	Metabolic Disease
AqF026 is an aquaporin 1 (AQP1) agonist. AqF026 enhances the channel activity of human AQP1 in the Xenopus laevis oocyte system. AqF026 enhances the osmotic transport of water across the peritoneum in a mouse model of peritoneal dialysis. AqF026 can be used in studies related to ultrafiltration failure in peritoneal dialysis ^[1] .

HY-N2013

Aristolactam I 1 Publications Verification Aristololactam; Aristolactam	Drug Metabolite Aquaporin Cadherin TGF-beta/Smad	Endocrinology Cancer
Aristolactam I is an *AQP1* inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates *Twist1* expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis ^[1] .

HY-110200

*TC AQP1* 1** 2 Publications Verification m-Phenylenediacrylic acid; m-Benzenediacrylic acid	Aquaporin	Metabolic Disease Cancer
TC AQP1 1 (m-Phenylenediacrylic acid) is a potent *AQP1* inhibitor. TC AQP1 1 inhibits AQP1-mediated water flux in oocytes, with an IC₅₀ of 8 μM ^[1].

HY-N6016

Bacopaside II 1 Publications Verification	Apoptosis Aquaporin	Cancer
Bacopaside II, an extract from the medicinal herb Bacopa monnieri. Bacopaside II is the inhibitor for *AQP1* that exhibits anti-angiogenesis activity. Bacopaside II exhibits cytotoxicity and induces apoptosis in cancer cells ^[1] .

HY-N4246

Bacopaside I	Aquaporin PKC Akt PI3K Apoptosis Monoamine Oxidase Pregnane X Receptor (PXR)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Bacopaside I is an orally active aquaporin *AQP1* inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of *AQP1* without affecting *AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt* pathway by interacting with PI3K, specifically inhibits MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases ^[1] .

HY-RS24200

Aqp1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Aqp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Aqp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aqp1 Rat Pre-designed siRNA Set A Aqp1 Rat Pre-designed siRNA Set A

HY-RS00871

AQP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AQP1 Human Pre-designed siRNA Set A contains three designed siRNAs for AQP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AQP1 Human Pre-designed siRNA Set A AQP1 Human Pre-designed siRNA Set A

HY-RS17735

Aqp1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Aqp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aqp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aqp1 Mouse Pre-designed siRNA Set A Aqp1 Mouse Pre-designed siRNA Set A

HY-N6016R

Bacopaside II (Standard)	Reference Standards Apoptosis Aquaporin	Cancer
Bacopaside II (Standard) is the analytical standard of Bacopaside II. This product is intended for research and analytical applications. Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis ^[1] .

HY-N4246R

Bacopaside I (Standard)	Reference Standards PKC Akt PI3K Apoptosis Pregnane X Receptor (PXR) Monoamine Oxidase Aquaporin	Neurological Disease
Bacopaside I (Standard) is the analytical standard of Bacopaside I. This product is intended for research and analytical applications. Bacopaside I is an orally active aquaporin *AQP1* inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of *AQP1* without affecting *AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt* pathway by interacting with PI3K, specifically inhibits MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases ^[1] .

HY-N2013R

Aristolactam I (Standard) Aristololactam (Standard); Aristolactam (Standard)	Reference Standards Caspase Apoptosis	Inflammation/Immunology
Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristolactam I is an *AQP1* inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates *Twist1* expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis ^[1] .

製品番号	製品名	Category	Target	構造式

HY-N2013

Aristolactam I 1 Publications Verification Aristololactam; Aristolactam	Structural Classification 天然物 other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	Drug Metabolite Aquaporin Cadherin TGF-beta/Smad
Aristolactam I is an *AQP1* inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates *Twist1* expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis ^[1] .

HY-N6016

Bacopaside II 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Scrophulariaceae Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst. Source Classification Cancer	Apoptosis Aquaporin
Bacopaside II, an extract from the medicinal herb Bacopa monnieri. Bacopaside II is the inhibitor for *AQP1* that exhibits anti-angiogenesis activity. Bacopaside II exhibits cytotoxicity and induces apoptosis in cancer cells ^[1] .

HY-N4246

Bacopaside I	Triterpenes Structural Classification Terpenoids Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst. Source Classification	Aquaporin PKC Akt PI3K Apoptosis Monoamine Oxidase Pregnane X Receptor (PXR)
Bacopaside I is an orally active aquaporin *AQP1* inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of *AQP1* without affecting *AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt* pathway by interacting with PI3K, specifically inhibits MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases ^[1] .

HY-N6016R

Bacopaside II (Standard)	Triterpenes Structural Classification Terpenoids Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst. Source Classification	Reference Standards Apoptosis Aquaporin
Bacopaside II (Standard) is the analytical standard of Bacopaside II. This product is intended for research and analytical applications. Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis ^[1] .

HY-N4246R

Bacopaside I (Standard)	Triterpenes Structural Classification Terpenoids Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst. Source Classification	Reference Standards PKC Akt PI3K Apoptosis Pregnane X Receptor (PXR) Monoamine Oxidase Aquaporin
Bacopaside I (Standard) is the analytical standard of Bacopaside I. This product is intended for research and analytical applications. Bacopaside I is an orally active aquaporin *AQP1* inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of *AQP1* without affecting *AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt* pathway by interacting with PI3K, specifically inhibits MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases ^[1] .

HY-N2013R

Aristolactam I (Standard) Aristololactam (Standard); Aristolactam (Standard)	天然物 other families Plants Source Classification	Reference Standards Caspase Apoptosis
Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristolactam I is an *AQP1* inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates *Twist1* expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis ^[1] .

Species:	Human (2)
Tag:	SUMO (1) His (1) GST (1)
Source:	E. coli (2)

製品番号	Compare	製品名	Species	Source	Image

HY-P72086

	AQP1 Protein, Human (GST) AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; CO blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO;	Human	E. coli
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (GST) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-GST labeled tag.

HY-P72085

	AQP1 Protein, Human (His-SUMO) AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; CO blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO; Colton blood group; Growth factor induced delayed early response protein; MGC26324; Urine water channel; Water channel protein CHIP 29; Water channel protein CHIP29; Water channel protein for red blood cells and kidney proximal tubule	Human	E. coli
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (His-SUMO) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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Source
Tag
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Gene ID
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Host:	Rabbit (4)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	IHC-P (4) ICC/IF (1) IF-Tissue (1) IHC-F (1) WB (2) ELISA (1)
Isotype:	IgG,Kappa (1) IgG (3)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P87817

	AQP1 Antibody (YA7502)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	AQP1 Antibody (YA7502) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to AQP1.

HY-P81404

	Aquaporin 1 Antibody (YA1149) AQP1; CHIP28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule	IHC-P	Human
	Aquaporin 1 Antibody (YA1149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 1.

HY-P81404A

	Aquaporin 1 Antibody (YA1149)(PBS only) AQP1; CHIP28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule	IHC-P	Human
	Aquaporin 1 Antibody (YA1149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 1.

HY-P86699

	Aquaporin 1 Antibody (YA6391) AQP 1; AQP-1; AQP1_HUMAN; Aquaporin-1; Aquaporin-CHIP; Channel like integral membrane protein 28 kDa; MGC26324; Water channel protein CHIP 29; AQP CHIP; AQP1; Aquaporin CHIP; Aquaporin1; Aquaporin 1; Channel forming integral protein 28kDa; CHIP 28; CHIP28; CO; Colton blood group; Growth factor induced delayed early response protein; Urine water channel; Water channel protein CHIP29; Water channel protein for red blood cells and kidney proximal tubule.	WB, IF-Tissue, IHC-P, IHC-F	Human, Mouse, Rat
	Aquaporin 1 Antibody (YA6391) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 1.

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Size	* This product has been "discontinued". Optimized version of product available: / 在庫あり - + カートに追加お問い合わせ

製品番号	製品名		Classification

HY-RS24200

Aqp1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Aqp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Aqp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00871

AQP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
AQP1 Human Pre-designed siRNA Set A contains three designed siRNAs for AQP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17735

Aqp1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Aqp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aqp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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