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Results for "

B0239

" in MedChemExpress (MCE) Product Catalog:

28

Inhibitors & Agonists

5

Biochemical Assay Reagents

3

Peptides

10

Natural
Products

5

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0239
    Chloramphenicol
    15+ Cited Publications

    		 Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy Apoptosis Beclin1 JNK Akt MMP Infection Cancer
    Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .
    Chloramphenicol
  • HY-B0239S
    Chloramphenicol-d5

    		Bacterial Antibiotic Infection
    Chloramphenicol-d5 is the deuterium labeled Chloramphenicol. Chloramphenicol is a broad-spectrum antibiotic against bacterial infections .
    Chloramphenicol-d5
  • HY-B0239R
    Chloramphenicol (Standard)

    		Reference Standards Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy Apoptosis Beclin1 JNK Akt MMP Infection Cancer
    Chloramphenicol (Standard) is the analytical standard of Chloramphenicol. This product is intended for research and analytical applications. Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .
    Chloramphenicol (Standard)
  • HY-B0239S2
    Threo-Chloramphenicol-d6

    		JNK Apoptosis VEGFR MMP Bacterial Akt Autophagy HIF/HIF Prolyl-Hydroxylase Antibiotic Beclin1 Cancer
    Threo-Chloramphenicol-d6 is the deuterium labeled Chloramphenicol . Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .
    Threo-Chloramphenicol-d6
  • HY-B0239S3
    Chloramphenicol-d4

    		Isotope-Labeled Compounds Bacterial Antibiotic Infection
    Chloramphenicol-d4 is deuterium labeled Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis . Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity .
    Chloramphenicol-d4
  • HY-B0239S1
    DL-threo-Chloramphenicol-d5

    		Isotope-Labeled Compounds Bacterial Antibiotic Others
    DL-threo-Chloramphenicol-d5 is a deuterium labeled DL-threo-Chloramphenicol. DL-threo-Chloramphenicol is the racemate of Chloramphenicol.
    DL-threo-Chloramphenicol-d5
  • HY-N7114A
    Chloramphenicol succinate sodium
    3 Publications Verification

    		 Bacterial P2Y Receptor Succinate Dehydrogenase Drug Intermediate Infection Inflammation/Immunology
    Chloramphenicol succinate sodium is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC50 of 1.585 nM. Chloramphenicol succinate sodium serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate sodium exerts a significant inhibitory effect on colitis. Chloramphenicol succinate sodium can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease .
    Chloramphenicol succinate sodium
  • HY-P1938
    Cyclo(L-Pro-L-Val)

    		Bacterial Infection Inflammation/Immunology
    Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases .
    Cyclo(L-Pro-L-Val)
  • HY-B1599
    Chloramphenicol palmitate

    		Bacterial Antibiotic Infection
    Chloramphenicol palmitate is an orally active prodrug of Chloramphenicol (HY-B0239), obtained from the esterification reaction between the agent and Palmitic acid (HY-N0830). Chloramphenicol palmitate is rapidly and completely hydrolyzed by intestinal esterase, releasing Chloramphenicol. Chloramphenicol is an orally effective broad-spectrum antibiotic .
    Chloramphenicol palmitate
  • HY-10393
    Eperezolid

    PNU-100592

    		 Bacterial Antibiotic Infection
    Eperezolid (PNU-100592) is an orally active protein synthesis inhibitor that targets the bacterial 50S ribosomal subunit. Eperezolid competitively binds to a specific site on the ribosomal 50S subunit (overlapping with the binding sites of chloramphenicol (HY-B0239) and lincomycin (HY-117660)) to inhibit the translation initiation stage and exert antibacterial activity. Eperezolid can induce host cell autophagy to enhance the clearance of intracellular mycobacteria, and its MIC90 for Staphylococcus aureus and Enterococcus is 1-4 μg/mL. Eperezolid is mainly used for antibacterial research on infections with Gram-positive bacteria such as methicillin-resistant (HY-121544) Staphylococci and vancomycin-resistant (HY-B0671) Enterococci, as well as infections with intracellular bacteria such as Mycobacterium tuberculosis .
    Eperezolid
  • HY-W007577
    4-Nitrobenzaldehyde

    		Drug Metabolite Others
    4-Nitrobenzaldehyde is a widely used industrial chemical intermediate and also the main photodegradation product of the broad-spectrum antibiotic Chloramphenicol (HY-B0239). 4-Nitrobenzaldehyde has genotoxic and mutagenic effects and poses a certain threat to human health and ecosystems .
    4-Nitrobenzaldehyde
  • HY-W016480
    4-Amino-L-phenylalanine

    		Drug Intermediate Infection Metabolic Disease
    4-Amino-L-phenylalanine is a metabolic intermediate. 4-Amino-L-phenylalanine can be used in the production of Chloramphenicol (HY-B0239) and Pristinamycin I in Streptomyces venezuelae and S. pristinaespiralis, respectively .
    4-Amino-L-phenylalanine
  • HY-Y0185
    4'-Nitroacetophenone

    		Biochemical Assay Reagents Drug Intermediate Others
    4'-Nitroacetophenone is a nitroaromatic compound. 4'-Nitroacetophenone is an important organic synthetic intermediate, which can be used for the synthesis of other active compounds such as Chloramphenicol (HY-B0239) .
    4'-Nitroacetophenone
  • HY-117682
    L-(+)-threo-Chloramphenicol

    (+)-Chloramphenicol; Dextramycine; Dextromycetin

    		 Antibiotic Infection
    L-(+)-threo-Chloramphenicol ((+)-Chloramphenicol) is the S,S-stereoisomer of Chloramphenicol (HY-B0239). L-(+)-Threo-chloramphenicol inhibits protein synthesis in reticulocytes. L-(+)-threo-Chloramphenicol also inhibits the oxidative activity of isolated mitochondria .
    L-(+)-threo-Chloramphenicol
  • HY-132271
    Chloramphenicol 1-acetate

    		Endogenous Metabolite Others
    Chloramphenicol 1-acetate (Compound Ⅲ) is a microbial transformation product of Chloramphenicol (HY-B0239) by Streptomyces coelicolor. Chloramphenicol 1-acetate is the major product of Chloramphenicol acetyltransferase I (CATI) by regioselective acetylation of C21 hydroxy groups in steroids .
    Chloramphenicol 1-acetate
  • HY-P5704
    K11

    		Bacterial Infection
    K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability .
    K11
  • HY-N7114
    Chloramphenicol succinate

    		Bacterial Drug Intermediate P2Y Receptor Succinate Dehydrogenase Infection Inflammation/Immunology
    Chloramphenicol succinate is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC50 of 1.585 nM. Chloramphenicol succinate serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate exerts a significant inhibitory effect on colitis. Chloramphenicol succinate can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease .
    Chloramphenicol succinate
  • HY-W706112
    Chloramphenicol-d5-2

    		Isotope-Labeled Compounds Antibiotic Infection
    Chloramphenicol-d5-2 is the deuterium labeled Chloramphenicol (HY-B0239). Chloramphenicol is an orally active, potent and broad-spectrum antibiotic .
    Chloramphenicol-d5-2
  • HY-W686760A
    Bromamphenicol

    		Bacterial Infection
    Bromamphenicol (Compound Ib) is a derivative of Chloramphenicol (HY-B0239), and exhibits antibacterial activity. Bromamphenicol binds to S50 ribosomal subunit, interfers with the activity of peptidyl transferase, and exhibits inhibitory activity against protein synthesis .
    Bromamphenicol
  • HY-123598
    Corynecin III

    		Antibiotic Bacterial Infection
    Corynecin III is a Chloramphenicol (HY-B0239)-like antibiotic, which is found in Corynebacterium. Corynecin III inhibits the growth of Gram-positive and Gram-negative bacteria with MIC values of 2.6-83 μg/mL .
    Corynecin III
  • HY-161587
    Chloramphenicol/OVA

    		Biochemical Assay Reagents Inflammation/Immunology
    Chloramphenicol/OVA is a conjugate of Chloramphenicol (HY-B0239) and Ovalbumin (OVA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes and can enhance cross-presentation and the production of antigen-specific T cells.
    Chloramphenicol/OVA
  • HY-161586
    Chloramphenicol/BSA

    		Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy Apoptosis Beclin1 JNK Akt MMP Biochemical Assay Reagents Inflammation/Immunology
    Chloramphenicol/BSA is the antigen-adjuvant conjugate formed by the coupling of Chloramphenicol (HY-B0239) with Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
    Chloramphenicol/BSA
  • HY-W007577R
    4-Nitrobenzaldehyde (Standard)

    		Reference Standards Drug Metabolite Others
    4-Nitrobenzaldehyde (Standard) is the analytical standard of 4-Nitrobenzaldehyde (HY-W007577). This product is intended for research and analytical applications. 4-Nitrobenzaldehyde is a widely used industrial chemical intermediate and also the main photodegradation product of the broad-spectrum antibiotic Chloramphenicol (HY-B0239). 4-Nitrobenzaldehyde has genotoxic and mutagenic effects and poses a certain threat to human health and ecosystems .
    4-Nitrobenzaldehyde (Standard)
  • HY-B1599R
    Chloramphenicol palmitate (Standard)

    		Reference Standards Bacterial Antibiotic Infection
    Chloramphenicol palmitate (Standard) is the analytical standard of Chloramphenicol palmitate (HY-B1599). This product is intended for research and analytical applications. Chloramphenicol palmitate is an orally active prodrug of Chloramphenicol (HY-B0239), obtained from the esterification reaction between the agent and Palmitic acid (HY-N0830). Chloramphenicol palmitate is rapidly and completely hydrolyzed by intestinal esterase, releasing Chloramphenicol. Chloramphenicol is an orally effective broad-spectrum antibiotic .
    Chloramphenicol palmitate (Standard)
  • HY-P1938R
    Cyclo(L-Pro-L-Val) (Standard)

    		Reference Standards Bacterial Infection
    Cyclo(L-Pro-L-Val) (Standard) is the analytical standard of Cyclo(L-Pro-L-Val). This product is intended for research and analytical applications. Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide[1].
    Cyclo(L-Pro-L-Val) (Standard)
  • HY-N7114AR
    Chloramphenicol succinate sodium (Standard)

    		Reference Standards Bacterial Drug Intermediate P2Y Receptor Succinate Dehydrogenase Infection Inflammation/Immunology
    Chloramphenicol succinate sodium (Standard) is the analytical standard of Chloramphenicol succinate sodium. This product is intended for research and analytical applications. Chloramphenicol succinate sodium is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC50 of 1.585 nM. Chloramphenicol succinate sodium serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate sodium exerts a significant inhibitory effect on colitis. Chloramphenicol succinate sodium can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease .
    Chloramphenicol succinate sodium (Standard)
  • HY-12770R
    Mebeverine alcohol (Standard)

    Mebeverine metabolite Mebeverine alcohol (Standard)

    		 Reference Standards Drug Metabolite Neurological Disease
    Mebeverine alcohol (Standard) is an analytical standard for Mebeverine alcohol. This product is intended for research and analytical applications. Eperezolid (PNU-100592) is an orally active protein synthesis inhibitor that targets the bacterial 50S ribosomal subunit. Eperezolid competitively binds to a specific site on the ribosomal 50S subunit (overlapping with the binding sites of Chloramphenicol (HY-B0239) and Lincomycin (HY-117660)) to inhibit the translation initiation stage and exert antibacterial activity. Eperezolid can induce host cell autophagy to enhance the clearance of intracellular mycobacteria, and its MIC90 for Staphylococcus aureus and Enterococcus is 1-4 μg/mL. Eperezolid is mainly used for antibacterial research on infections with Gram-positive bacteria such as methicillin-resistant (HY-121544) Staphylococci and vancomycin-resistant (HY-B0671) Enterococci, as well as infections with intracellular bacteria such as Mycobacterium tuberculosis .
    Mebeverine alcohol (Standard)
  • HY-W686760
    (Rac)-Bromamphenicol

    		Bacterial Infection
    (Rac)-Bromamphenicol is the racemate of Bromamphenicol (HY-W686760). Bromamphenicol (Compound Ib) is a derivative of Chloramphenicol (HY-B0239), and exhibits antibacterial activity. Bromamphenicol binds to S50 ribosomal subunit, interfers with the activity of peptidyl transferase, and exhibits inhibitory activity against protein synthesis .
    (Rac)-Bromamphenicol

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