Cyclo(L-Pro-L-Val)
Based on 1 Customer Validation
Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.14%
- CAS No.: 2854-40-2
- Formule: C10H16N2O2
- Masse moléculaire:196.25
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Stockage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | EC50 |
>100 μM
Compound: DKPPVal
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Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
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[PMID: 36518704] |
| HCT-116 | EC50 |
>100 μM
Compound: DKPPVal
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Cytotoxicity against human HCT-116 cells overexpressing human BCRP incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells overexpressing human BCRP incubated for 48 hrs by MTT assay
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[PMID: 36518704] |
| HCT-116 | EC50 |
>100 μM
Compound: DKPPVal
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Cytotoxicity against human HCT-116 cells overexpressing human MDR1 incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells overexpressing human MDR1 incubated for 48 hrs by MTT assay
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[PMID: 36518704] |
| HEK293 | EC50 |
>100 μM
Compound: DKPPVal
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Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
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[PMID: 36518704] |
| Neutrophil | IC50 |
2.79 μg/mL
Compound: 28
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Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release
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[PMID: 21848266] |
| Neutrophil | IC50 |
6.59 μg/mL
Compound: 28
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Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation
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[PMID: 21848266] |
Cyclo(L-Pro-L-Val) (MIC=19.6 mg/mL) shows toxic activity comparable to that of 25 mg/mL Chloramphenicol (HY-B0239) in the antibacterial experiment against Rhodococcus fascians LMG 3605 and could reduce the viability of Rhodococcus fascians LMG 3605 cells[1]Cyclo(L-Pro-L-Val) (25-100 μM; treated for 1 hour and then co-incubated with LPS for 24 hours) significantly inhibits the production of NO in RAW 264.7 macrophages stimulated by LPS in the anti-inflammatory experiment of RAW 264.7 macrophages, and the inhibitory effect is equivalent to that of L-NMMA (HY-18732)[2]Cyclo(L-Pro-L-Val) (50-100 μM；24 h) inhibits the phosphorylation of IKKα, IKKβ, and NF-κB, as well as the activation of iNOS and COX-2 in RAW 264.7 macrophages induced by LPS in a concentration-dependent manner[2]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 macrophages
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Concentration:50 μM, 100 μM
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Incubation Time:Treated for 1 hour and then co-incubated with 1 μg/mL LPS for 24 h
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Result:Significantly inhibited expression of IKKα/β, I-κBα, and NF-κB in a concentration dependent manner.
Chemical Information
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CAS No. 2854-40-2
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Appearance Solid
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Masse moléculaire 196.25
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Formule C10H16N2O2
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Color White to off-white
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Sequence
Cyclo(Pro-Val)
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Sequence Shortening
Cyclo(PV)
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Structure Classification
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Initial Source
Streptomyces strain ML 1532
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvant et solubilité
DMSO : 100 mg/mL (509.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Cimmino A, et al. Isolation of 2,5-diketopiperazines from Lysobacter capsici AZ78 with activity against Rhodococcus fascians. Nat Prod Res. 2021 Dec;35(23):4969-4977. [Content Brief]
[2]. Lee D, et al. Bioactive Phytochemicals from Mulberry: Potential Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. Int J Mol Sci. 2021 Jul 29;22(15):8120. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.0955 mL | 25.4777 mL | 50.9554 mL | 127.3885 mL |
| 5 mM | 1.0191 mL | 5.0955 mL | 10.1911 mL | 25.4777 mL | |
| 10 mM | 0.5096 mL | 2.5478 mL | 5.0955 mL | 12.7389 mL | |
| 15 mM | 0.3397 mL | 1.6985 mL | 3.3970 mL | 8.4926 mL | |
| 20 mM | 0.2548 mL | 1.2739 mL | 2.5478 mL | 6.3694 mL | |
| 25 mM | 0.2038 mL | 1.0191 mL | 2.0382 mL | 5.0955 mL | |
| 30 mM | 0.1699 mL | 0.8493 mL | 1.6985 mL | 4.2463 mL | |
| 40 mM | 0.1274 mL | 0.6369 mL | 1.2739 mL | 3.1847 mL | |
| 50 mM | 0.1019 mL | 0.5096 mL | 1.0191 mL | 2.5478 mL | |
| 60 mM | 0.0849 mL | 0.4246 mL | 0.8493 mL | 2.1231 mL | |
| 80 mM | 0.0637 mL | 0.3185 mL | 0.6369 mL | 1.5924 mL | |
| 100 mM | 0.0510 mL | 0.2548 mL | 0.5096 mL | 1.2739 mL |
Cyclo(L-Pro-L-Val) Related Classifications
HY-P1938 Related Classifications
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