2. Anti-infection GPCR/G Protein Others Metabolic Enzyme/Protease
  3. Drug Intermediate P2Y Receptor Bacterial Succinate Dehydrogenase
  4. Chloramphenicol succinate

Chloramphenicol succinate is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC50 of 1.585 nM. Chloramphenicol succinate serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate exerts a significant inhibitory effect on colitis. Chloramphenicol succinate can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease.

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Chloramphenicol succinate

Chloramphenicol succinate Chemical Structure

CAS No. : 3544-94-3

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Chloramphenicol succinate Related Antibodies

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Description

Chloramphenicol succinate is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC50 of 1.585 nM. Chloramphenicol succinate serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate exerts a significant inhibitory effect on colitis. Chloramphenicol succinate can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease[1][2][3].

In Vitro

Chloramphenicol succinate (50 μM; 3-24 h) is slowly oxidized to Chloramphenicol by cultured human bone marrow monocytes within 24 h[1].
Chloramphenicol succinate (50-100 μM; 30-60 min) is oxidized to Chloramphenicol by mitochondria isolated from human liver, rat liver and rat kidney within 60 min[1].
Chloramphenicol succinate is hydrolyzed by esterases present in the liver, kidney and lung of humans and animals, but not by blood esterases[2].
Chloramphenicol succinate ((0.01-100 μM; 24 h) exhibits only extremely low cytotoxicity against HT-29 cells when incubated at concentrations up to 100 μM for 24 h[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chloramphenicol succinate Related Antibodies
In Vivo

Chloramphenicol succinate (50-100 μM; administered rectally; once daily for 7 consecutive days) significantly alleviates DSS (HY-116282C)-induced colitis in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J (male, 7-8-week-old, DSS-induced colitis)[3]
Dosage: 50 μM; 100 μM
Administration: rectal; daily; 7 days
Result: Significantly attenuated DSS-induced colitis symptoms.
Reduced weight loss.
Lowered Disease Activity Index (DAI) scores.
Prevented colon shortening.
Mitigated colon tissue damage and inflammatory cell infiltration.
Enhanced gut barrier integrity via increased expression of tight junction proteins (Claudin-1, Occludin, ZO-1).
Molecular Weight

423.20

Formula

C15H16Cl2N2O8
CAS No.
SMILES

O=C(OC[C@@H](NC(C(Cl)Cl)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)CCC(O)=O
Structure Classification
Initial Source

Streptomyces venequelae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Chloramphenicol succinate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chloramphenicol3544-94-3Drug IntermediateP2Y ReceptorBacterialSuccinate DehydrogenaseDrug IintermediateInhibitorinhibitorinhibit

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