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  3. Chloramphenicol succinate sodium

Chloramphenicol succinate sodium 

Cat. No.: HY-N7114A Purity: >98.0%
Handling Instructions

Chloramphenicol succinate sodium is a prodrug of Chloramphenicol, with Haemotoxicity. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity.

For research use only. We do not sell to patients.

Chloramphenicol succinate sodium Chemical Structure

Chloramphenicol succinate sodium Chemical Structure

CAS No. : 982-57-0

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Chloramphenicol succinate sodium is a prodrug of Chloramphenicol, with Haemotoxicity. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity[1][2][3].

Molecular Weight

445.18

Formula

C₁₅H₁₅Cl₂N₂NaO₈

CAS No.

982-57-0

SMILES

O=C(CCC(O[Na])=O)OC[[email protected]]([[email protected]@H](C1=CC=C(C=C1)[N+]([O-])=O)O)NC(C(Cl)Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under argon)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (561.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2463 mL 11.2314 mL 22.4628 mL
5 mM 0.4493 mL 2.2463 mL 4.4926 mL
10 mM 0.2246 mL 1.1231 mL 2.2463 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.67 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Chloramphenicol succinateBacterialAntibioticInhibitorinhibitorinhibit

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Product Name:
Chloramphenicol succinate sodium
Cat. No.:
HY-N7114A
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