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Results for "

C3G/Crk Inhibitors

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

5

Recombinant Proteins

15

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-127105
    Iptacopan
    Maximum Cited Publications
    13 Publications Verification

    LNP023

    		 Complement System Metabolic Disease Inflammation/Immunology
    Iptacopan (LNP023) is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) [3].
    Iptacopan
  • HY-127105A
    Iptacopan hydrochloride
    Maximum Cited Publications
    13 Publications Verification

    LNP023 hydrochloride

    		 Complement System Metabolic Disease Inflammation/Immunology
    Iptacopan (LNP023) hydrochloride is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) [3].
    Iptacopan hydrochloride
  • HY-112622
    GSK3186899

    DDD-853651

    		 Parasite Cancer
    GSK3186899 (DDD-853651) is an inhibitor of cdc-2-related kinase 12 (CRK12), with an EC50 of 1.4 μM for L. donovani in an intra-macrophage assay.
    GSK3186899
  • HY-112346
    RGB-286147

    		CDK Apoptosis Cancer
    RGB-286147 is a selective and ATP-competitive CDK and CDK-related kinases (CRK) inhibitor with IC50 values ranging from 9-839 nM. RGB-286147 shows less active against other non-CDK/CRK kinases. RGB-286147 induces cell apoptosis, and exhibits anti-tumor activity .
    RGB-286147
  • HY-200854
    Iptacopan hydrochloride hydrate

    LNP023 hydrochloride hydrate

    		 Complement System Metabolic Disease Inflammation/Immunology
    Iptacopan (LNP023) hydrochloride hydrate is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride hydrate exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride hydrate can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) [3].
    Iptacopan hydrochloride hydrate
  • HY-143322
    CRK12-IN-2

    		Parasite Infection
    CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis .
    CRK12-IN-2
  • HY-145812
    CRK12-IN-1

    		Parasite Infection
    CRK12-IN-1 is a potent CRK12 inhibitor. CRK12-IN-1 is extremely potent against T.b. brucei and rapidly cytocidal, as well as equally potent against T. congolense and T. vivax (EC50 of 1.3 and 18 nM, respectively) .
    CRK12-IN-1
  • HY-RS23979
    Crk Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Crk Rat Pre-designed siRNA Set A contains three designed siRNAs for Crk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Crk Rat Pre-designed siRNA Set A
    Crk Rat Pre-designed siRNA Set A
  • HY-RS03184
    CRK Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CRK Human Pre-designed siRNA Set A contains three designed siRNAs for CRK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CRK Human Pre-designed siRNA Set A
    CRK Human Pre-designed siRNA Set A
  • HY-RS16222
    Crk Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Crk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Crk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Crk Mouse Pre-designed siRNA Set A
    Crk Mouse Pre-designed siRNA Set A
  • HY-127105B
    Iptacopan TFA

    LNP023 TFA

    		 Complement System Metabolic Disease Inflammation/Immunology
    Iptacopan (LNP023) TFA is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan TFA exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan TFA can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) [3].
    Iptacopan TFA
  • HY-155716
    G43-C3-TEG

    		Bacterial Glucosylceramide Synthase (GCS) Infection
    G43-C3-TEG is a glycosyl-transferase inhibitor. G43-C3-TEG reduces the biofilm formation by decreasing the production of EPS (extracellular polysaccharides) .
    G43-C3-TEG

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