CRKL Protein, Human
Based on 1 Customer Validation
CRKL protein mediates intracellular signal transduction, interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1, and plays a role in erythropoietin receptor and phosphoinositide signaling. It also binds to DOCK2 and DOCK5, suggesting regulation of guanine nucleotide exchange factors. CRKL Protein, Human is the recombinant human-derived CRKL protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
CRKL protein mediates intracellular signal transduction, interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1, and plays a role in erythropoietin receptor and phosphoinositide signaling. It also binds to DOCK2 and DOCK5, suggesting regulation of guanine nucleotide exchange factors. CRKL Protein, Human is the recombinant human-derived CRKL protein, expressed by E. coli , with tag free.
The CRKL protein is implicated in mediating the transduction of intracellular signals, indicating its role in cellular signaling pathways. It interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1, suggesting its involvement in pathways associated with erythropoietin receptor signaling and phosphoinositide signaling. Additionally, CRKL interacts with DOCK2 and DOCK5 via its first SH3 domain, highlighting its potential role in modulating guanine nucleotide exchange factors. The protein further engages with phosphorylated CBLB and IRS4, indicating its participation in pathways related to cellular proliferation and insulin receptor signaling. Furthermore, CRKL interacts with BCAR1/CAS and NEDD9/HEF1, suggesting its involvement in signaling cascades associated with cell adhesion and migration. These diverse interactions underscore the versatility of CRKL in transmitting signals within the cell.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P46109 (M1-E303)
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Gene ID1399
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Molecular Construction
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N-term
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CRKL (M1-E303)
Accession # P46109 -
C-term
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Protein Length
Full Length
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Synonyms
CRKL; Crk-Like Protein; CRK Like Proto-Oncogene, Adaptor Protein; Alternative Protein CRKL; V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like
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AA Sequence
MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPDENE
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Predicted Molecular Mass
33.9 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Supplied as a 0.22 μm filtered solution of 50 mM HEPES, pH7.5, 200 mM NaCl, 20% glycerol, 1 mM DTT.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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