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RAPGEF1 Antibody (YA8220)

(Synonyms: C3G; GRF2)
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RAPGEF1 Antibody (YA8220) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAPGEF1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, IHC-P, ICC/IF, ChIP

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:1000-2000 1:100-200 1:100-250

Product Details

Description

RAPGEF1 Antibody (YA8220) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAPGEF1.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
Immunogen

Full length human recombinant protein of human RAPGEF1 produced in HEK293T cell.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    RAPGEF1 is a Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth[1].

  • Subcellular Localization

    Early endosome

  • Expression


    Tissue_Specificity: Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver

  • Isoforms & Post-Translational Modification

    Q13905 has four isomers: Q13905-1: 120548 Da (predicted); Q13905-2: 116141 Da (predicted); Q13905-3: 122735 Da (predicted); Q13905-4: 122287 Da (predicted).
    Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor

  • Subunit

    Interacts with HCK (via SH3-binding sites) (PubMed:14551197)

  • SwissProt ID

    Q13905

  • Synonyms

    C3G; GRF2

RAPGEF1 Antibody (YA8220) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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