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DENV-IN-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dengue Virus (14) DNA/RNA Synthesis (3) Flavivirus (5) HIV (1) Ligands for Target Protein for PROTAC (1) Virus Protease (4)
By Research Areas:	Infection (15)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12957

NITD008 10+ Cited Publications 7-Deaza-2'-C-acetylene-adenosINe	Flavivirus Dengue Virus DNA/RNA Synthesis	Infection
NITD008 is a potent and selective flaviviruse inhibitor which can inhibit Dengue Virus Type 2 (DENV-2) with an EC₅₀ of 0.64 μM. NITD008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N3942

Glabranine	Flavivirus Dengue Virus HIV	Infection
Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus . Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein ^[2].

HY-144612

NS2B/NS3-IN-2	Flavivirus Dengue Virus Virus Protease	Infection
NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC₅₀ of 6.0 nM and K_i of 0.66 µM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate .

HY-138061

*DENV-IN-2*	Flavivirus Dengue Virus DNA/RNA Synthesis	Infection
DENV-IN-2 is a potent dengue viral replication inhibitor extracted from patent WO2018215315A1, compound 6AB, has an EC₅₀ of 0.016 nM. DENV-IN-2 shows high potent activity against all four serotypes of the Dengue virus with EC₅₀s ranging from 0.013 to 0.029 nM .

HY-112254

ZINC03129319	Flavivirus Dengue Virus Virus Protease	Infection
ZINC03129319 is a dengue virus (DENV) NS2B-NS3 protease inhibitor extracted from patent US20150141521A1, has inhibition constants (K_i1) of 92 μM and K_i3 of 20 μM.

HY-162485

DV-B-120	Dengue Virus Virus Protease	Infection
DV-B-120 is a competitive inhibitor for dengue virus (DENV) with IC₅₀s of 5.35, 7.39, 10.49 and 8.58 μM, for DENV-1, DENV-2, DENV-3 and DENV-4, respectively, by inhibiting NS2B-NS3 protease. DV-B-120 exhibits antiviral activity through inhibition of DENV replication .

HY-P991769

Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96)	Dengue Virus	Infection
Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96) reacts with sites along the lateral ridge of the DIII domain on the E protein of dengue virus serotype 2 (DENV-2). Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96) against DENV-2 new Guinea C (NGC) infection in mice. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981) .

HY-149467

JMX0254	Dengue Virus Virus Protease	Infection
JMX0254 is an orally active and potent inhibitor of the dengue virus NS4B protein. JMX0254’s EC₅₀ for DENV-1, DENV-2, and DENV-3 are 0.78 µM, 0.16 µM, and 0.035 µM, respectively. JMX0254 can be used for research on viral infections .

HY-161808

*DENV ligand 2*	Dengue Virus Ligands for Target Protein for PROTAC	Infection
DENV ligand 2 is the ligand for DENV E protein.DENV ligand 2 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806). DENV ligand 2 is the active form of DENV ligand 1 (HY-161807) .

HY-157550

DENV-IN-12	Dengue Virus	Infection
DENV-IN-12 (Compound 6) is a derivative of N-methylcytisine thio, which inhibits *DENV-1* and *DENV-2. DENV-IN-12 displays robust antiviral activity against DENV-2, with EC₅₀* values ranging from 0.002 to 0.005 μM in different cell lines .

HY-168914

AI-181	Dengue Virus	Infection
A181 (AI-181) is a *DENV-2* inhibitor. A181 can be used for anti-dengue studies .

HY-155129

Antiviral agent 36	DNA/RNA Synthesis	Infection
Antiviral agent 36 (compound 27) is a potent dengue (DENV) and Zika (ZIKV) viruses inhibitor. Antiviral agent 36 inhibits replication of Zika and dengue virus with EC₅₀s of 100 nM, 90 nM, 210 nM, and 120 nM for ZIKV-FLR, ZIKV-HN16, DENV-2, and DENV-3, respectively .

HY-172907

SMU-1k	Dengue Virus	Infection
SMU-1k is a highly effective and broad-spectrum antiviral agent. SMU-1k inhibits ZIKV and *DENV-2* with EC₅₀s of 7.08 and 3.96 μM, respectively. SMU-1k significantly inhibits NS5 protein expression and restores the level of *STAT2* .

HY-N12407

Peridinin	Dengue Virus	Infection
Peridinin is a hydroxylated carotenoid ketone that exhibits inhibitory activity against *DENV NS2B/NS3* protease and all dengue virus serotypes (DENV-1, *DENV-2, DENV-3, DENV-4*). Peridinin inhibits dengue virus production and reduces viral titers. Peridinin is applicable to research related to dengue virus infection .

HY-182042

DENV-IN-15	Dengue Virus	Infection
DENV-IN-15 is a sulfonyl anthranilic acid derivative and a pan-serotype anti-dengue virus (DENV) inhibitor with broad-spectrum anti-RNA virus activity. The EC₅₀ value of DENV-IN-15 against DENV-2 in Huh-7 cells is 0.7 μM. DENV-IN-15 selectively regulates the translation of mRNAs encoding translation-related proteins and containing a 5'-oligopyrimidine tract. DENV-IN-15 reduces the expression of specific ribosomal proteins, thereby inhibiting viral replication. DENV-IN-15 exhibits enhanced membrane permeability, human plasma stability and human liver microsomal metabolic stability. DENV-IN-15 is applicable to research related to dengue virus infection .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991769

Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96)	Dengue Virus	Infection
Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96) reacts with sites along the lateral ridge of the DIII domain on the E protein of dengue virus serotype 2 (DENV-2). Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96) against DENV-2 new Guinea C (NGC) infection in mice. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981) .

Glabranine	Infection Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Source Classification	Flavivirus Dengue Virus HIV
Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus . Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein ^[2].

Peridinin	Structural Classification Natural Products Classification of Application Fields Ketones, Aldehydes, Acids Marine natural products Other marine organisms Pigments Source Classification Food Research	Dengue Virus
Peridinin is a hydroxylated carotenoid ketone that exhibits inhibitory activity against *DENV NS2B/NS3* protease and all dengue virus serotypes (DENV-1, *DENV-2, DENV-3, DENV-4*). Peridinin inhibits dengue virus production and reduces viral titers. Peridinin is applicable to research related to dengue virus infection .

Cat. No.	Product Name		Classification

HY-12957

NITD008 10+ Cited Publications 7-Deaza-2'-C-acetylene-adenosINe		Alkynes
NITD008 is a potent and selective flaviviruse inhibitor which can inhibit Dengue Virus Type 2 (DENV-2) with an EC₅₀ of 0.64 μM. NITD008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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