1. Anti-infection
  2. Virus Protease
  3. ZINC03129319

ZINC03129319 

Cat. No.: HY-112254 Purity: 98.33%
Handling Instructions

ZINC03129319 is a dengue virus (DENV) NS2B-NS3 protease inhibitor extracted from patent US20150141521A1, has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.

For research use only. We do not sell to patients.

ZINC03129319 Chemical Structure

ZINC03129319 Chemical Structure

CAS No. : 1777807-64-3

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 308 In-stock
Estimated Time of Arrival: December 31
25 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ZINC03129319 is a dengue virus (DENV) NS2B-NS3 protease inhibitor extracted from patent US20150141521A1, has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.

IC50 & Target

Ki1: 92±15 μM (DENV NS2B-NS3 protease)[1]
Ki3: 20±4 μM (DENV NS2B-NS3 protease)[1]

In Vitro

ZINC03129319 inhibits DENV NS2B-NS3 protease with Ki1 of 92±15 μM and Ki3 of 20±4 μM[1].

Molecular Weight

490.51

Formula

C₂₄H₁₄N₂O₆S₂

CAS No.

1777807-64-3

SMILES

O=C1C2(SC[[email protected]]3N2C([[email protected]@H]4N(C5(C(C(C=CC=C6)=C6C5=O)=O)SC4)C3=O)=O)C(C7=CC=CC=C71)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (84.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0387 mL 10.1935 mL 20.3869 mL
5 mM 0.4077 mL 2.0387 mL 4.0774 mL
10 mM 0.2039 mL 1.0193 mL 2.0387 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (4.24 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.24 mM); Clear solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.33%

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Keywords:

ZINC03129319ZINC 03129319ZINC-03129319Virus ProteaseInhibitorinhibitorinhibit

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Product name:
ZINC03129319
Cat. No.:
HY-112254
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