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ZINC03129319 

Cat. No.: HY-112254
Handling Instructions

ZINC03129319 is a dengue virus (DENV) NS2B-NS3 protease inhibitor extracted from patent US20150141521A1, has inhibition constants (Ki1) of 92±15 μM and Ki3 of 20±4 μM.

For research use only. We do not sell to patients.

ZINC03129319 Chemical Structure

ZINC03129319 Chemical Structure

CAS No. : 1777807-64-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 308 In-stock
Estimated Time of Arrival: December 31
25 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Description

ZINC03129319 is a dengue virus (DENV) NS2B-NS3 protease inhibitor extracted from patent US20150141521A1, has inhibition constants (Ki1) of 92±15 μM and Ki3 of 20±4 μM.

IC50 & Target

Ki1: 92±15 μM (DENV NS2B-NS3 protease)[1]
Ki3: 20±4 μM (DENV NS2B-NS3 protease)[1]

In Vitro

ZINC03129319 inhibits DENV NS2B-NS3 protease with Ki1 of 92±15 μM and Ki3 of 20±4 μM[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (84.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0387 mL 10.1935 mL 20.3869 mL
5 mM 0.4077 mL 2.0387 mL 4.0774 mL
10 mM 0.2039 mL 1.0193 mL 2.0387 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (4.24 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.24 mM); Clear solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

490.51

Formula

C₂₄H₁₄N₂O₆S₂

CAS No.

1777807-64-3

SMILES

O=C1C2(SC[[email protected]]3N2C([[email protected]@H]4N(C5(C(C(C=CC=C6)=C6C5=O)=O)SC4)C3=O)=O)C(C7=CC=CC=C71)=O

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
ZINC03129319
Cat. No.:
HY-112254
Quantity:

ZINC03129319

Cat. No.: HY-112254