2. Anti-infection
  3. Dengue Virus Virus Protease
  4. JMX0254

JMX0254 is an orally active and potent inhibitor of the dengue virus NS4B protein. JMX0254’s EC50 for DENV-1, DENV-2, and DENV-3 are 0.78 µM, 0.16 µM, and 0.035 µM, respectively. JMX0254 can be used for research on viral infections.

For research use only. We do not sell to patients.

JMX0254

JMX0254 Chemical Structure

CAS No. : 2375960-04-4

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JMX0254 Related Antibodies

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Description

JMX0254 is an orally active and potent inhibitor of the dengue virus NS4B protein. JMX0254’s EC50 for DENV-1, DENV-2, and DENV-3 are 0.78 µM, 0.16 µM, and 0.035 µM, respectively. JMX0254 can be used for research on viral infections[1].

Cellular Effect
Cell Line Type Value Description References
Huh-7 CC50
> 10 μM
Compound: 15; JMX0254
Cytotoxicity in human HuH7 replicon cells infected with Dengue virus 2 NGC assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-Glo reagent based assay
Cytotoxicity in human HuH7 replicon cells infected with Dengue virus 2 NGC assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-Glo reagent based assay
[PMID: 31403780]
Molecular Weight

498.40

Formula

C25H25Cl2N5O2
CAS No.
SMILES

O=C1[C@@]2(C3=C(NC(C2)=O)N(N=N3)[C@H](C4=CC=C(C=C4)Cl)C)C5=CC(Cl)=CC=C5N1CCC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JMX0254 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMX02542375960-04-4JMX 0254JMX-0254Dengue VirusVirus ProteaseDENVdengue virusDENV-1DENV-2DENV-3infectionInhibitorinhibitorinhibit

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