DENV-IN-12
DENV-IN-12 (Compound 6) is a derivative of N-methylcytisine thio, which inhibits DENV-1 and DENV-2. DENV-IN-12 displays robust antiviral activity against DENV-2, with EC50 values ranging from 0.002 to 0.005 μM in different cell lines.
For research use only. We do not sell to patients.
- CAS No.: 2581065-80-5
- Formula: C12H14N2OS
- Molecular Weight:234.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>50 μM
Compound: 6
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Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
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[PMID: 38242331] |
| Vero C1008 | CC50 |
>50 μM
Compound: 6
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Cytotoxicity against african green monkey Vero E6 cells by MTT assay
Cytotoxicity against african green monkey Vero E6 cells by MTT assay
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[PMID: 38242331] |
Chemical Information
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CAS No. 2581065-80-5
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Molecular Weight 234.32
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Formula C12H14N2OS
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SMILES
O=C1C=CC=C([C@@H]2C3)N1C[C@@H]3CN(C)C2=S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DENV-IN-12 Related Classifications
HY-157550 Related Classifications
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