2. Anti-infection
  3. Dengue virus Flavivirus Virus Protease
  4. NS2B/NS3-IN-2

NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC50 of 6.0 nM and Ki of 0.66 µM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate.

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NS2B/NS3-IN-2 Chemical Structure

NS2B/NS3-IN-2 Chemical Structure

CAS No. : 3010940-08-3

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NS2B/NS3-IN-2 Related Antibodies

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Description

NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC50 of 6.0 nM and Ki of 0.66 µM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate[1].

IC50 & Target

IC50: 6.0 nM (NS2B/NS3)[1]
In Vitro

NS2B/NS3-IN-2 (compound 23) (150 nM) shows 100% inhibition rate against Dengue virus (DENV)[1].
NS2B/NS3-IN-2 (5 µM) shows no cytotoxicity and markedly increases the cell survival rate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NS2B/NS3-IN-2 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Infected BHK-21 cells after DENV infection
Concentration: 5 µM
Incubation Time: 5 days
Result: Showed no cytotoxicity and markedly increased the cell survival rate.
Molecular Weight

463.51

Formula

C24H21N3O5S
CAS No.
SMILES

O=S(C(C=C1)=CC=C1OCC)(N2N=C(C=C2N)OC(C3=CC=C(C=C3)C4=CC=CC=C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NS2B/NS3-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NS2B/NS3-IN-23010940-08-3Dengue virusFlavivirusVirus ProteaseDENVBHK-21 cellsno cytotoxicitycovalent inhibitorInhibitorinhibitorinhibit

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