DENV-IN-15
DENV-IN-15 is a sulfonyl anthranilic acid derivative and a pan-serotype anti-dengue virus (DENV) inhibitor with broad-spectrum anti-RNA virus activity. The EC50 value of DENV-IN-15 against DENV-2 in Huh-7 cells is 0.7 μM. DENV-IN-15 selectively regulates the translation of mRNAs encoding translation-related proteins and containing a 5'-oligopyrimidine tract. DENV-IN-15 reduces the expression of specific ribosomal proteins, thereby inhibiting viral replication. DENV-IN-15 exhibits enhanced membrane permeability, human plasma stability and human liver microsomal metabolic stability. DENV-IN-15 is applicable to research related to dengue virus infection.
For research use only. We do not sell to patients.
- Formula: C28H34N4O3S
- Molecular Weight:506.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DENV-IN-15 (compound 7; 48 h) acts as a pan-serotypic DENV inhibitor in Huh-7 cells, with EC50 values of 0.14 μM (DENV-1), 0.03 μM (DENV-3), and 0.09 μM (DENV-4)[1].
DENV-IN-15 inhibits ZIKV replication in Huh-7 cells, with an EC50 of 0.12 μM at 24 h[1].
DENV-IN-15 (0.0488-50 μM; 48 h) inhibits EV71 replication in SH-SY5Y cells, with an EC50 of 0.10 μM[1].
DENV-IN-15 exhibits favorable in vitro ADME properties, with a Papp of 2.93 × 10-6 cm/s, excellent plasma stability, a human liver microsome half-life of 59.8 min, and a CLint of 18.8 mL·min-1·kg-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7 cells
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Concentration:10 μM
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Incubation Time:24 h (starting 6 h post-transfection)
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Result:Significantly reduced ectopic Flag-NS5 protein expression driven by the wild-type 5′-TOP motif.
Had no effect on Flag-NS5 expression from the mutant 5′-TOP motif-driven construct.
DENV-IN-15 (10 μM; 2 or 4 days) exhibits no cytotoxicity against human brain organoids[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Embryonic stem cell-derived dorsal forebrain cortical organoids (day 60, early maturation stage)[1]
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Dosage:5 μM
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Administration:in culture media; single dose post-infection; up to 96 hours
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Result:Reduced ZIKV infection by approximately 70% at 48 hours post-infection.
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Animal Model:Embryonic stem cell-derived dorsal forebrain organoids[1]
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Dosage:10 μM
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Administration:in culture media; single dose; 2 or 4 days
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Result:Showed no detectable cytotoxicity at 2 days or 4 days post-treatment, with cell viability comparable to untreated controls.
Chemical Information
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Molecular Weight 506.66
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Formula C28H34N4O3S
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SMILES
O=C(NCC1CCCCC1)C2=CC(N3CCCCC3)=CC=C2NS(C4=C(N=CC=C5)C5=CC=C4)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DENV-IN-15 Related Classifications
HY-182042 Related Classifications
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