2. Anti-infection
  3. Dengue Virus
  4. DENV-IN-15

DENV-IN-15 is a sulfonyl anthranilic acid derivative and a pan-serotype anti-dengue virus (DENV) inhibitor with broad-spectrum anti-RNA virus activity. The EC50 value of DENV-IN-15 against DENV-2 in Huh-7 cells is 0.7 μM. DENV-IN-15 selectively regulates the translation of mRNAs encoding translation-related proteins and containing a 5'-oligopyrimidine tract. DENV-IN-15 reduces the expression of specific ribosomal proteins, thereby inhibiting viral replication. DENV-IN-15 exhibits enhanced membrane permeability, human plasma stability and human liver microsomal metabolic stability. DENV-IN-15 is applicable to research related to dengue virus infection.

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DENV-IN-15

DENV-IN-15 Chemical Structure

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DENV-IN-15 Related Antibodies

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Description

DENV-IN-15 is a sulfonyl anthranilic acid derivative and a pan-serotype anti-dengue virus (DENV) inhibitor with broad-spectrum anti-RNA virus activity. The EC50 value of DENV-IN-15 against DENV-2 in Huh-7 cells is 0.7 μM. DENV-IN-15 selectively regulates the translation of mRNAs encoding translation-related proteins and containing a 5'-oligopyrimidine tract. DENV-IN-15 reduces the expression of specific ribosomal proteins, thereby inhibiting viral replication. DENV-IN-15 exhibits enhanced membrane permeability, human plasma stability and human liver microsomal metabolic stability. DENV-IN-15 is applicable to research related to dengue virus infection[1].

In Vitro

DENV-IN-15 (compound 7; 48 h) acts as a pan-serotypic DENV inhibitor in Huh-7 cells, with EC50 values of 0.14 μM (DENV-1), 0.03 μM (DENV-3), and 0.09 μM (DENV-4)[1].
DENV-IN-15 inhibits ZIKV replication in Huh-7 cells, with an EC50 of 0.12 μM at 24 h[1].
DENV-IN-15 (0.0488-50 μM; 48 h) inhibits EV71 replication in SH-SY5Y cells, with an EC50 of 0.10 μM[1].
DENV-IN-15 exhibits favorable in vitro ADME properties, with a Papp of 2.93 × 10-6 cm/s, excellent plasma stability, a human liver microsome half-life of 59.8 min, and a CLint of 18.8 mL·min-1·kg-1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DENV-IN-15 Related Antibodies

Western Blot Analysis[1]

Cell Line: Huh-7 cells
Concentration: 10 μM
Incubation Time: 24 h (starting 6 h post-transfection)
Result: Significantly reduced ectopic Flag-NS5 protein expression driven by the wild-type 5′-TOP motif.
Had no effect on Flag-NS5 expression from the mutant 5′-TOP motif-driven construct.
In Vivo

DENV-IN-15 (compound 7) (5 μM; 48 h) inhibits ZIKV infection in human brain organoids by approximately 70%[1].
DENV-IN-15 (10 μM; 2 or 4 days) exhibits no cytotoxicity against human brain organoids[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Embryonic stem cell-derived dorsal forebrain cortical organoids (day 60, early maturation stage)[1]
Dosage: 5 μM
Administration: in culture media; single dose post-infection; up to 96 hours
Result: Reduced ZIKV infection by approximately 70% at 48 hours post-infection.
Animal Model: Embryonic stem cell-derived dorsal forebrain organoids[1]
Dosage: 10 μM
Administration: in culture media; single dose; 2 or 4 days
Result: Showed no detectable cytotoxicity at 2 days or 4 days post-treatment, with cell viability comparable to untreated controls.
Molecular Weight

506.66

Formula

C28H34N4O3S
SMILES

O=C(NCC1CCCCC1)C2=CC(N3CCCCC3)=CC=C2NS(C4=C(N=CC=C5)C5=CC=C4)(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DENV-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DENV-IN-15Dengue VirusDENVdengue virusDENV-2human brain organoidsribosomal proteinsHuh-7 cellsSH-SY5Y cellsEV715'-terminal oligopyrimidine motifZIKVRNA virusInhibitorinhibitorinhibit

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