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Diacylglycerol lipase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) DAGL (8) Lipase (6) MAGL (2) Biochemical Assay Reagents (2) COX (2) Endogenous Metabolite (2) mAChR (2) Phospholipase (2) Reference Standards (1)
By Research Areas:	Inflammation/Immunology (4) Metabolic Disease (14) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Recombinant Proteins

Click Chemistry

Targets Recommended: DAGL Lipase DGK MAGL Hormone-Sensitive Lipase (HSL) ATGL Acyltransferase

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-18540

KT109 1 Publications Verification	MAGL DAGL	Metabolic Disease Inflammation/Immunology
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC₅₀ of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC₅₀=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages .

HY-107416

RHC 80267 U-57908	DAGL Acyltransferase mAChR COX Phospholipase	Neurological Disease Metabolic Disease
RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC₅₀ of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC₅₀ of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC) .

HY-120171

DH-376	DAGL MAGL	Metabolic Disease
DH-376 is a potent **diacylglycerol lipase inhibitor with pIC₅₀** values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. DH-376 prevents fasting-induced refeeding of mice . DH-376 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-18551

DAGLβ-IN-1	DAGL	Inflammation/Immunology
DAGLβ-IN-1 is an inhibitor of diacylglycerol lipase-β (DAGLβ), serves as a versatile intermediate for the design of DAGL-tailored activity-based probes .

HY-117771A

DO34 analog	DAGL	Neurological Disease Metabolic Disease
DO34 analog is a structural analog of DO34 (HY-117771). DO34 is a selective DAGL inhibitor, with an IC₅₀ of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 can be used for the research of energy balance disorder and neuroinflammation .

HY-W127391

1,2-Dilaurin (Rac)-1,2-Didodecanoylglycerol	Biochemical Assay Reagents	Others
1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

HY-112828

LEI105	DAGL	Neurological Disease Metabolic Disease Inflammation/Immunology
LEI105 is a potent, highly selective and reversible dual diacylglycerol lipase (DAGL)-α/DAGL-β inhibitor. LEI105 reduces 2-arachidonoylglycerol levels in Neuro2A cells. LEI105 also reduces cannabinoid CB1-receptor-mediated short-term synaptic plasticity in a mouse hippocampal slice model. LEI105 is promising for research of diseases, such as obesity, related metabolic disorders and neuroinflammation .

HY-126031A

(S)-KT109	Endogenous Metabolite	Others
(S)-KT109 is an inhibitor of diacylglycerol lipase β (DAGLβ) with low inhibitory activity (IC50 = 39.81 nM). (S)-KT109 has relatively low inhibitory activity against DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM). (S)-KT109 also has relatively low inhibitory activity against α/β-amidase domain-containing 6 (ABHD6) (IC50 = 630.9 nM) .

HY-W778471

rac-1-Linoleoyl-3-linolenoyl-propanetriol DG(18:2/0:0/18:3); 1-Linolein-3-α-Linolenin; 1-Linolein-3-Linolenin	Endogenous Metabolite	Metabolic Disease
1-Linoleoyl-3-α-linolenoyl-rac-glycerol is a diacylglycerol that contains linoleic acid (HY-N0729) at the sn-1 position and α-linolenic acid (HY-N0728) at the sn-3 position. It has been found in olive oil subjected to lipase-catalyzed glycerolysis with immobilized lipase B from C. antarctica.

HY-107416R

RHC 80267 (Standard) U-57908 (Standard)	DAGL Reference Standards Acyltransferase mAChR COX Phospholipase	Neurological Disease Metabolic Disease
RHC 80267 (Standard) is the analytical standard of RHC 80267 (HY-107416). This product is intended for research and analytical applications. RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC₅₀ of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC₅₀ of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC) .

HY-Y1422U

Lipase, Mucor miehei	Biochemical Assay Reagents	Metabolic Disease
Lipase, Mucor miehei (EC 3.1.1.3) is an enzyme that hydrolyzes triacylglycerols. Lipase, Mucor miehei (EC 3.1.1.3) catalyzes the reaction of triacylglycerols to diacylglycerols and carboxylates.

HY-Y1422T

Lipase, Porcine	Lipase	Metabolic Disease
Lipase, Porcine (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

HY-Y1422P

Lipase, Rhizopus oryzae	Lipase	Metabolic Disease
Lipase, Rhizopus oryzae (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

HY-Y1422Q

Lipase, Rhizopus niveus	Lipase	Metabolic Disease
Lipase, Rhizopus niveus (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

HY-Y1422O

Lipase, Thermus flavus	Lipase	Metabolic Disease
Lipase, Thermus flavus (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

HY-Y1422N

Lipase, Thermus thermophilus	Lipase	Metabolic Disease
Lipase, Thermus thermophilus (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

HY-Y1422M

Lipase,wheat germ	Lipase	Metabolic Disease
Lipase,wheat germ (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

HY-118340

L-Isoleucine orlistat	DAGL	Inflammation/Immunology
L-Isoleucine orlistat (Compound 15) is a diacylglycerol lipase α (DAGLα) inhibitor with an IC₅₀ value of < 50 nM. L-Isoleucine orlistat is promising for research of neural signaling and inflammation-related diseases .

Cat. No.	상품명	Type

HY-W127391

1,2-Dilaurin (Rac)-1,2-Didodecanoylglycerol	Biochemical Assay Reagents
1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

1,2-Dilaurin

(Rac)-1,2-Didodecanoylglycerol

Biochemical Assay Reagents

1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

Cat. No.	Compare	상품명	Species	Source	Image

HY-P703648

	LIPA Protein, Human (P. pastoris, His) Lysosomal acid lipase/cholesteryl ester hydrolase; Cholesteryl esterase; Diacylglycerol lipase; Sterol esterase	Human	P. pastoris
	LIPA Protein, Human (P. pastoris, His) is the recombinant human-derived LIPA protein, expressed by P. pastoris, with N-6*His tag.

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Cat. No.	상품명		Classification

HY-120171

DH-376		Alkynes
DH-376 is a potent **diacylglycerol lipase inhibitor with pIC₅₀** values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. DH-376 prevents fasting-induced refeeding of mice . DH-376 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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