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Cat. No.: HY-Y1422T

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Lipase, Porcine

Lipase, Porcine is an orally active triglyceride hydrolase and fat absorption enhancer. Lipase, Porcine catalyzes the breakdown of triglycerides into fatty acids, as well as the hydrolysis of triglycerides and other carboxylic acid esters. Lipase, Porcine increases the absorption coefficients of fats, proteins and carbohydrates. Lipase, Porcine can be used in studies related to exocrine pancreatic insufficiency and congenital pancreatic triglyceride lipase deficiency.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Lipase, Porcine Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Lipase, Porcine (3 min) catalyzes the regioselective hydrolysis of Mimusops elengi and Parkinsonia aculeata seed oils at pH 8.0 and 40 °C^[3].
Lipase, Porcine (60 min) hydrolyzes fish oil at pH 8.0 and 38 °C, with a hydrolysis rate of 46%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lipase, Porcine (30,000-300,000 IU; p.o.; prandial; twice daily; 72-hour fecal collection periods) increases fat absorption in a dose-dependent manner in pancreatic-insufficient dogs, with 300,000 IU (17.94 g) achieving a CFA of 85% and nearly eliminating steatorrhea^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

female, 18-21 kg (pancreatic ducts ligated, connections between duodenum and pancreatic head transected, confirmed absence of intraduodenal protease and lipase activity)^[1]
Dosage:

30,000 IU (1.8 g); 135,000 IU (8.1 g); 300,000 IU (17.94 g)
Administration:

p.o.; prandial; twice daily; 72-hour fecal collection periods
Result:

Increased coefficient of fat absorption (CFA) dose-dependently.
Reached a CFA of 77% at 30,000 IU.
Reached a CFA of 81% at 135,000 IU.
Reached a CFA of 85% at 300,000 IU.
Nearly abolished steatorrhea at 300,000 IU.
Matched the efficacy of 600,000 IU of bacterial lipase at 300,000 IU.

Chemical Information

SMILES

[Lipase, Porcine]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Suzuki A, et al. Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic-insufficient dogs. Gastroenterology. 1999 Feb;116(2):431-7. [Content Brief]

[2]. Bagi K, et al. Immobilization and characterization of porcine pancreas lipase[J]. Enzyme and Microbial Technology, 1997, 20(7): 531-535.

[3]. Mendes A A, et al. Properties and biotechnological applications of porcine pancreatic lipase[J]. Journal of Molecular Catalysis B: Enzymatic, 2012, 78: 119-134.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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