2. Metabolic Enzyme/Protease
  3. DAGL
  4. DO34 analog

DO34 analog is a structural analog of DO34 (HY-117771). DO34 is a selective DAGL inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 can be used for the research of energy balance disorder and neuroinflammation.

For research use only. We do not sell to patients.

DO34 analog

DO34 analog Chemical Structure

CAS No. : 2098969-71-0

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Based on 1 publication(s) in Google Scholar

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DO34 analog Related Antibodies

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DAGLα DAGLβ

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Description

DO34 analog is a structural analog of DO34 (HY-117771). DO34 is a selective DAGL inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 can be used for the research of energy balance disorder and neuroinflammation[1][2][3].

IC50 & Target[1]

DAGLα

6 nM (IC50)

DAGLβ

 

In Vitro

DO34 analog is a structural analog of DO34 (HY-117771). DO34 is a selective DAGL inhibitor with an IC50 of 6 nM for the conversion of SAG to 2-AG by DAGLα. DO34 blocks the de novo synthesis of 2-AG and inhibits the tonic activation of CB1 receptors. DO34 blocks the depolarization-induced excitation and inhibition effects in the cerebellum and hippocampus. DO34 modulates feeding behavior and spontaneous activity in mice. DO34 eliminates the enhancement of excitatory postsynaptic currents induced by parallel fibers in cerebellar slices of MAGL knockout mice by AM251. DO34 can be used in the study of energy balance disorders and neuroinflammation[1][2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DO34 analog Related Antibodies
Molecular Weight

531.53

Formula

C26H28F3N5O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1C(CC2=CC=CC=C2)CN(C(OC(C)(C)C)=O)CC1)N3N=CC(C4=CC=C(OC(F)(F)F)C=C4)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 105 mg/mL (197.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8814 mL 9.4068 mL 18.8136 mL
5 mM 0.3763 mL 1.8814 mL 3.7627 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.42%

SDS (251 KB)

COA (250 KB) LCMS (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8814 mL 9.4068 mL 18.8136 mL 47.0340 mL
5 mM 0.3763 mL 1.8814 mL 3.7627 mL 9.4068 mL
10 mM 0.1881 mL 0.9407 mL 1.8814 mL 4.7034 mL
15 mM 0.1254 mL 0.6271 mL 1.2542 mL 3.1356 mL
20 mM 0.0941 mL 0.4703 mL 0.9407 mL 2.3517 mL
25 mM 0.0753 mL 0.3763 mL 0.7525 mL 1.8814 mL
30 mM 0.0627 mL 0.3136 mL 0.6271 mL 1.5678 mL
40 mM 0.0470 mL 0.2352 mL 0.4703 mL 1.1759 mL
50 mM 0.0376 mL 0.1881 mL 0.3763 mL 0.9407 mL
60 mM 0.0314 mL 0.1568 mL 0.3136 mL 0.7839 mL
80 mM 0.0235 mL 0.1176 mL 0.2352 mL 0.5879 mL
100 mM 0.0188 mL 0.0941 mL 0.1881 mL 0.4703 mL
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DO34 analog Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DO342098969-71-0DO 34DO-34DAGLDiacylglycerol lipaseDAG lipaseDGLmicecerebellumMAGL global knockout cerebellar slices2-arachidonoylglyceroldiacylglycerol lipaseenergy balance disorderhippocampusCB1 receptorneuroinflammationDAGLαInhibitorinhibitorinhibit

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