RHC 80267 (Standard)
RHC 80267 (Standard) is the analytical standard of RHC 80267 (HY-107416). This product is intended for research and analytical applications. RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC).
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- No. CAS: 83654-05-1
- Fòrmula: C20H34N4O4
- Peso molecular:394.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureza y Documentación
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Help & FAQs
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HY-107416
RHC 80267Diacylglycerol Lipase Inhibitor -
HY-70072
D609PC-PLC Inhibitor -
HY-108630
U-73343U-73122 Negative Control -
HY-19619
m-3M3FBSPhospholipase C Activator -
HY-100168
BAPTACalcium Chelator -
HY-N6796
Manumycin AAntibiotic, TrxR-1 Inhibitor -
HY-19363
GW4869N-SMase Inhibitor -
HY-108611
AACOCF3cPLA2 Inhibitor -
HY-13402
VarespladibsPLA2 Inhibitor -
HY-N0134
Tanshinone IPhospholipase Inhibitor -
HY-130592
Compound 48/80 trihydrochlorideHistamine Releaser/Mast Cell Degranulator
Product Information
Information
Aplicación
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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No. CAS 83654-05-1
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Peso molecular 394.51
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Fòrmula C20H34N4O4
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SMILES
O=C(O/N=C1CCCCC\1)NCCCCCCNC(O/N=C2CCCCC/2)=O
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Synonyms
U-57908 (Standard)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Sutherland CA, et al. Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267. J Biol Chem. 1982 Dec 10;257(23):14006-10. [Content Brief]
[2]. Ghisdal P, et al. The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action. Eur J Pharmacol. 2005 Jul 4;517(1-2):97-102. [Content Brief]
[3]. Karpińska O, et al. Activation of CB1 receptors by 2-arachidonoylglycerol attenuates vasoconstriction induced by U46619 and angiotensin II in human and rat pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2017 Jun 1;312(6):R883-R893. [Content Brief]
[4]. Oglesby TD, et al. The inhibition of arachidonic acid metabolism in human platelets by RHC 80267, a diacylglycerol lipase inhibitor. Biochim Biophys Acta. 1984 Apr 18;793(2):269-77. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RHC 80267 (Standard) Related Classifications
HY-107416R Related Classifications
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