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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
Drug addiction
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "Drug addiction" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-P2259
CAS No.: 1404188-93-7
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Cat. No.: HY-111308
CAS No.: 847554-50-1
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RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve agent addiction including selectively decrease self-administration .
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Fenobam is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction .
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KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 and 880 nM for PDE4B and PDE4D, respectively. KVA-D-88 induces cAMP accumulation and inhibits neuroactive substance-mediated hyperlocomotion, locomotor sensitization. KVA-D-88 can be used for the research of drug addiction .
Cat. No.: HY-116910
CAS No.: 640897-20-7
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CPP-115 is a GABA transaminase inactivator with higher affinity and lower retinal toxicity than Vigabatrin (HY-15399). CPP-115 increases brain GABA levels by inhibiting GABA transaminase catabolism. CPP-115 can be used in the study of drug addiction and infantile spasms .
Cat. No.: HY-P2046
CAS No.: 309246-19-3
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Cat. No.: HY-158014
CAS No.: 1627576-64-0
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JJC8-089 is a dopamine transporter (DAT) inhibitor that may improve motivational dysfunction and increase effortful behavior in goal-directed activities. JJC8-089 significantly reversed the low-effort effects induced by the VMAT-2 inhibitor Tetrabenazine (HY-B0590) in rats and increased the choice of high-effort fixed-ratio 5-bar presses versus food intake. .
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Dibromsalicil (Compound 31) is a carboxylesterase (CES) inhibitor with activity of 72.7 nM against hiCE (human intestinal carboxylesterase) and 53.5 nM against rCE (rabbit liver carboxylesterase). Dibromsalicil has almost no activity against hCE1 (human liver carboxylesterase) and cholinesterase .
Cat. No.: HY-101478A
CAS No.: 63540-28-3
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Fenobam hydrate is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam hydrate shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam hydrate has anxiolytic activity, inhibits self-administration behavior in rat, and induces apoptosis in cancer cells. Fenobam hydrate can be used for research on neurological diseases, cancer and drug addiction .
Cat. No.: HY-174898
CAS No.: 2873459-44-8
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5-HT2C agonist-9 (Compound 33) is a 5-HT2C agonist with an EC50 of 1.4 nM for h5-HT2C. 5-HT2C agonist-9 can be used in the research of diseases such as depression, drug addiction, alcoholism, PTSD and neuropathic pain .
Cat. No.: HY-175191
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5-HT2A agonist 4 (Compound 70) is a 5-HT2A agonist with an EC50 of 0.30 nM for h5-HT2A. 5-HT2A agonist 4 can be used for depression, drug addiction, alcoholism, post-traumatic stress disorder (PTSD), and neuropathic pain research .
Cat. No.: HY-175192
CAS No.: 2952978-05-9
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5-HT2A agonist 5 (Compound 88) is a 5-HT2A agonist with an EC50 of 0.01 nM for h5-HT2A. 5-HT2A agonist 5 can be used for depression, drug addiction, alcoholism, post-traumatic stress disorder (PTSD), and neuropathic pain research .
Cat. No.: HY-103573
CAS No.: 1274859-33-4
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VU 0360223 is a potent metabotropic glutamate receptors (mGluR) negative allosteric modulator with an IC50 of 61 nM .
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NNC63-0532 is a novel non-peptide nociceptin receptor (ORL1) agonist, with EC50s of 305 nM. NNC63-0532 plays important roles in many disorders such as pain, drug addiction .
Cat. No.: HY-11056
CAS No.: 1010382-72-5
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PF-04363467 is a highly preferring D3R antagonist. PF-04363467 produces dose-dependent changes in the EEG profile of freely moving rats. PF-4363467 attenuates opioid drug-seeking behavior without concomitant D2 side effects. PF-04363467 can be used for the study of addiction, cognitive and mental illness .
Cat. No.: HY-101478R
CAS No.: 57653-26-6
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Fenobam (Standard) is the analytical standard of Fenobam. This product is intended for research and analytical applications. Fenobam is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction .
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AI 3-25755 (OMS-403) is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist. AI 3-25755 can be used for research on opioid abuse and smoking cessation .
Cat. No.: HY-179594
CAS No.: 81682-91-9
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HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease .
Cat. No.: HY-182551
CAS No.: 1623019-77-1
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SR-12062 is a Neurotensin receptor 1 (NTSR1) full agonist that modulates NTSR1 to trigger intracellular Ca 2+ mobilization. SR-12062 can be used for the research of schizophrenia, parkinson’s disease, drug addiction .
Cat. No.: HY-123848
CAS No.: 928046-68-8
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CTDP-32476 is a dopamine transporter (DAT) inhibitor with antidepressant activity, exhibiting a Ki value of 12 nM for human DAT and moderate affinity for the norepinephrine transporter (NET). CTDP-32476 blocks DAT to increase extracellular dopamine levels, and induces locomotor stimulation and brain-stimulation reward effects in rats. CTDP-32476 is used in research related to drug addiction .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
