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Art. -Nr.: HY-182011

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GPR6 inverse agonist 2

GPR6 inverse agonist 2 (Compound 575) is a selective GPR6 inverse agonist, with IC₅₀ values of < 0.1 μM and 1~30 μM against GPR6 and GPR3, respectively. GPR6 inverse agonist 2 exhibits preliminary cardiac safety, with an IC₅₀ of 21.71 μM for hERG. GPR6 inverse agonist 2 can be used in the research of movement disorders such as Parkinson's disease.

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CAS. Nr.: 3029155-57-2
Formel: C₂₇H₃₁F₂N₇O₂
Molecular Weight:523.58

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Please store the product under the recommended conditions in the Certificate of Analysis.

GPR6 inverse agonist 2 Chemical Structure

CAS. Nr.: 3029155-57-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Beschreibung

Chemical Information

CAS. Nr. 3029155-57-2
Molecular Weight 523.58
Formel C₂₇H₃₁F₂N₇O₂
SMILES

CC(C)(O)[C@@H](O)C1=CC2=NC(N3CCN(CC4=CC=C(F)C=C4F)CC3)=C(C5=CN(CC)N=C5)N=C2C=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Li Y, et al. Discovery of Pyridopyrazine Inverse Agonists Targeting G Protein-Coupled Receptor 6. ACS Med Chem Lett. 2026;17(3):634-636. Published 2026 Mar 3. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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