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Cat. No.: HY-182011

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GPR6 inverse agonist 2

GPR6 inverse agonist 2 (Compound 575) is a selective GPR6 inverse agonist, with IC₅₀ values of < 0.1 μM and 1~30 μM against GPR6 and GPR3, respectively. GPR6 inverse agonist 2 exhibits preliminary cardiac safety, with an IC₅₀ of 21.71 μM for hERG. GPR6 inverse agonist 2 can be used in the research of movement disorders such as Parkinson's disease.

For research use only. We do not sell to patients.

CAS No.: 3029155-57-2
Formula: C₂₇H₃₁F₂N₇O₂
Molecular Weight:523.58

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Please store the product under the recommended conditions in the Certificate of Analysis.

GPR6 inverse agonist 2 Chemical Structure

CAS No.: 3029155-57-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Chemical Information

CAS No. 3029155-57-2
Molecular Weight 523.58
Formula C₂₇H₃₁F₂N₇O₂
SMILES

CC(C)(O)[C@@H](O)C1=CC2=NC(N3CCN(CC4=CC=C(F)C=C4F)CC3)=C(C5=CN(CC)N=C5)N=C2C=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Discovery of Pyridopyrazine Inverse Agonists Targeting G Protein-Coupled Receptor 6. ACS Med Chem Lett. 2026;17(3):634-636. Published 2026 Mar 3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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