Discovery of Pyridopyrazine Inverse Agonists Targeting G Protein-Coupled Receptor 6

  • ACS Med Chem Lett. 2026 Mar 3;17(3):634-636. doi: 10.1021/acsmedchemlett.6c00096.
Yinlong Li  1 ,  Steven H Liang  1  2
Affiliations
  • 1. Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
  • 2. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, United States.
PMID: 41847644 DOI: 10.1021/acsmedchemlett.6c00096
Abstract

This patent highlight describes the synthesis and assessment of a series of new inverse agonists targeting G protein-coupled receptor 6 (GPR6) based on pyridopyrazine analogs. It details their chemical synthesis, characterization, and biological activity assays.

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