Search Result
Results for "
N-desmethyl
" in MedChemExpress (MCE) Product Catalog:
32
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-12388A
-
desmethylclomipramine hydrochloride
|
Drug Metabolite
|
Neurological Disease
|
N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .
|
-
-
- HY-12388AS
-
desmethylclomipramine D3 hydrochloride
|
Drug Metabolite
|
Neurological Disease
|
N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]
|
-
-
- HY-70002AS
-
N-desmethyl MDV 3100-d6
|
|
|
N-desmethyl Enzalutamide-d6 is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].
|
-
-
- HY-70002A
-
N-desmethyl MDV 3100
|
Androgen Receptor
|
Cancer
|
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .
|
-
-
- HY-G0010
-
-
-
- HY-132626S
-
-
-
- HY-141750S1
-
-
-
- HY-143922S
-
-
-
- HY-12388AR
-
desmethylclomipramine hydrochloride (Standard)
|
Drug Metabolite
|
Neurological Disease
|
N-Desmethyl Clomipramine (hydrochloride) (Standard) is the analytical standard of N-Desmethyl Clomipramine (hydrochloride). This product is intended for research and analytical applications. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .
|
-
-
- HY-132344S
-
-
-
- HY-139519S
-
-
-
- HY-G0010S
-
-
-
- HY-144143S
-
-
-
- HY-W754151
-
|
Isotope-Labeled Compounds
|
Others
|
N-Desmethyl apalutamide-d4 is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .
|
-
-
- HY-143767S
-
-
-
- HY-143810S
-
|
Isotope-Labeled Compounds
|
Others
|
N-Desmethyl Mifepristone-d3 is the deuterium labeled N-Desmethyl Mifepristone[1]. N-Desmethyl Mifepristone-d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
-
- HY-150544S
-
|
Isotope-Labeled Compounds
|
Others
|
N-Desmethyl Selegiline-dd5 hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride[1]. N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
-
- HY-Z3203S
-
-
-
- HY-143931S
-
-
-
- HY-G0017
-
Norimatinib; Imatinib metabolite N-desmethyl imatinib
|
Drug Metabolite
|
Others
|
N-Desmethyl imatinib (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .
|
-
-
- HY-G0017A
-
Norimatinib mesylate; Imatinib metabolite N-desmethyl imatinib mesylate
|
Drug Metabolite
|
Others
|
N-Desmethyl imatinib mesylate (Norimatinib mesylate) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .
|
-
-
- HY-G0017S
-
Norimatinib-d8; Imatinib metabolite N-desmethyl imatinib-d8
|
Drug Metabolite
|
Cancer
|
N-Desmethyl imatinib-d8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.
|
-
-
- HY-W295339S
-
-
-
- HY-100647S
-
-
-
- HY-120422S
-
-
-
- HY-G0017S1
-
Norimatinib-d4; Imatinib metabolite N-desmethyl imatinib-d4
|
Isotope-Labeled Compounds
|
Others
|
N-Desmethyl imatinib-d4 is the deuterium-labeled N-Desmethyl imatinib (HY-G0017). N-Desmethyl imatinib-d4 (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .
|
-
-
- HY-144386S
-
-
-
- HY-N7612
-
N-Norgalanthamine
|
Cholinesterase (ChE)
|
Others
|
N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM .
|
-
-
- HY-118788S
-
-
-
- HY-118601S
-
-
-
- HY-135392
-
AC-279
|
Drug Metabolite
|
Neurological Disease
|
N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
|
-
-
- HY-117605
-
desmethylsildenafil; UK-103,320
|
Phosphodiesterase (PDE)
|
Cardiovascular Disease
|
N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .
|
-
-
- HY-142283BS
-
|
EGFR
|
Cancer
|
N-Desmethyl dosimertinib-d5 is the deuterium labeled Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].
|
-
-
- HY-117605S
-
-
-
- HY-135331
-
|
Androgen Receptor
Cytochrome P450
|
Cancer
|
N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .
|
-
-
- HY-128038S
-
-
-
- HY-132709S
-
-
-
- HY-128038
-
|
Opioid Receptor
|
Neurological Disease
|
N-Desmethyl-loperamide is a major metabolite of loperamide, a drug that selectively activates peripheral μopioid receptors with a Ki value of 0.16 nM. N-Desmethyl-loperamide is a substrate of the ATP-dependent efflux transporter P-glycoprotein .
|
-
-
- HY-131629
-
-
-
- HY-108226S
-
-
-
- HY-108226S1
-
-
-
- HY-144144S
-
-
-
- HY-143949S
-
-
-
- HY-143834S
-
-
-
- HY-139689S
-
|
Isotope-Labeled Compounds
|
Others
|
rac-trans-N-Desmethyl sertraline-d3 (hydrochloride) is the deuterium labeled rac-trans-N-Desmethyl sertraline hydrochloride[1].
|
-
-
- HY-135161
-
|
Drug Metabolite
|
Others
|
EDDP perchlorate is an N-desmethyl metabolite of Methadone by intestinal, hepatic, and cytochrome P450 (CYP) 3A4 .
|
-
-
- HY-146102
-
|
mAChR
|
Others
|
M1 ligand 1 (compound 3b-b) is a muscarinic acetylcholine receptor M1 ligand. M1 ligand 1 is a N-desmethyl congener of arecoline derivative. M1 ligand 1 can be used as PET (positron emission tomography) radiotracer .
|
-
-
- HY-P1108
-
|
CFTR
|
Others
|
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying .
|
-
-
- HY-P1108A
-
|
CFTR
|
Others
|
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying .
|
-
-
- HY-P4521
-
|
MMP
|
Others
|
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate, and can be used to detect MMP12 enzyme activity .
|
-
- HY-P3066
-
d(CH2)5Tyr(Et)VAVP
|
Vasopressin Receptor
|
Metabolic Disease
|
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .
|
-
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1108A
-
|
CFTR
|
Others
|
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying .
|
-
- HY-P4756
-
|
Peptides
|
Others
|
N-(2-Carbamoyl-ethyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
-
- HY-P1108
-
|
CFTR
|
Others
|
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying .
|
-
- HY-P2592
-
|
Peptides
|
Others
|
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .
|
-
- HY-P4521
-
|
MMP
|
Others
|
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate, and can be used to detect MMP12 enzyme activity .
|
-
- HY-P3066
-
d(CH2)5Tyr(Et)VAVP
|
Vasopressin Receptor
|
Metabolic Disease
|
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-12388AS
-
|
N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]
|
-
-
- HY-143922S
-
|
N-Desmethyl Bedaquiline-d6 is the deuterium labeled N-Desmethyl Bedaquiline[1].
|
-
-
- HY-132626S
-
|
N-Desmethyl Tamoxifen-d5 is the deuterium labeled N-Desmethyl Tamoxifen[1].
|
-
-
- HY-141750S1
-
|
N-Desmethyl Zolmitriptan-d3 is the deuterium labeled N-Desmethyl Zolmitriptan[1].
|
-
-
- HY-132344S
-
|
N-Desmethyl asenapine-d4 (hydrochloride) is the deuterium labeled N-Desmethyl asenapine hydrochloride[1].
|
-
-
- HY-139519S
-
|
N-Desmethyl diphenhydramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl diphenhydramine hydrochloride[1].
|
-
-
- HY-G0010S
-
|
N-desmethyl Netupitant-d6 is the deuterium labeled N-desmethyl Netupitant, which is a metabolite of Netupitant.
|
-
-
- HY-144143S
-
|
N-Desmethyl Olopatadine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Olopatadine hydrochloride[1].
|
-
-
- HY-W754151
-
|
N-Desmethyl apalutamide-d4 is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .
|
-
-
- HY-143767S
-
|
N-Desmethyl Azelastine-d4-1 is the deuterium labeled N-Desmethyl Azelastine[1].
|
-
-
- HY-143810S
-
|
N-Desmethyl Mifepristone-d3 is the deuterium labeled N-Desmethyl Mifepristone[1]. N-Desmethyl Mifepristone-d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
-
- HY-150544S
-
|
N-Desmethyl Selegiline-dd5 hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride[1]. N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
-
- HY-Z3203S
-
|
N-Desmethyl Rosuvastatin-d6 (disodium) is the deuterium labeled N-Desmethyl Rosuvastatin disodium[1].
|
-
-
- HY-143931S
-
|
N-Desmethyl citalopram-d4 (oxalate) is the deuterium labeled N-Desmethyl citalopram oxalate[1].
|
-
-
- HY-G0017S
-
|
N-Desmethyl imatinib-d8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.
|
-
-
- HY-W295339S
-
|
N-Desmethyl venlafaxine-d3 is a deuterium labeled compound.
|
-
-
- HY-100647S
-
|
N-Desmethyl Nefopam-d4 (hydrochloride) is deuterium labeled N-Desmethylnefopam (hydrochloride).
|
-
-
- HY-120422S
-
|
N-Desmethyl Regorafenib-d3 is deuterium labeled BAY-751098.
|
-
-
- HY-G0017S1
-
|
N-Desmethyl imatinib-d4 is the deuterium-labeled N-Desmethyl imatinib (HY-G0017). N-Desmethyl imatinib-d4 (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .
|
-
-
- HY-144386S
-
|
N-Desmethyl L-ergothioneine methyl ester-d6 is the deuterium labeled N-Desmethyl L-ergothioneine methyl ester[1].
|
-
-
- HY-118788S
-
|
N-Desmethyl Rosiglitazone-d4 is the deuterium labeled N-Desmethyl Rosiglitazone[1].
|
-
-
- HY-118601S
-
|
N-Desmethyl Pirenzepine-d8 is the deuterium labeled N-Desmethyl Pirenzepine[1].
|
-
-
- HY-142283BS
-
|
N-Desmethyl dosimertinib-d5 is the deuterium labeled Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].
|
-
-
- HY-117605S
-
|
N-Desmethyl Sildenafil-d8 is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2][3].
|
-
-
- HY-128038S
-
|
N-Desmethyl-loperamide-d3 is the deuterium labeled N-Desmethyl-loperamide[1].
|
-
-
- HY-132709S
-
|
N-Desmethyl-diltiazem-d4 (hydrochloride) is the deuterium labeled N-Desmethyl-diltiazem hydrochloride[1].
|
-
-
- HY-108226S
-
|
Regorafenib N-oxide and N-desmethyl (M5)-d3 is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).
|
-
-
- HY-108226S1
-
|
Regorafenib N-oxide and N-desmethyl (M5)- 13C6 is the 13C-labeled Regorafenib N-oxide and N-desmethyl (M5)[1].
|
-
-
- HY-144144S
-
|
(E)-N-Desmethyl Olopatadine-d3 (hydrochloride) is the deuterium labeled (E)-N-Desmethyl Olopatadine.
|
-
-
- HY-143949S
-
|
(Rac)-N-desmethyl Dapoxetine-d7 hydrochloride is the deuterium labeled (Rac)-N-desmethyl Dapoxetine hydrochloride[1].
|
-
-
- HY-143834S
-
|
O-Desacetyl-N-desmethyl Diltiazem-d3 is the deuterium labeled O-Desacetyl-N-desmethyl Diltiazem[1].
|
-
-
- HY-139689S
-
|
rac-trans-N-Desmethyl sertraline-d3 (hydrochloride) is the deuterium labeled rac-trans-N-Desmethyl sertraline hydrochloride[1].
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-150544S
-
|
|
Alkynes
|
N-Desmethyl Selegiline-dd5 hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride[1]. N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent: