Search Result
Results for "
NH2-PEG2000-NH2
" in MedChemExpress (MCE) Product Catalog:
12
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W451406C
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PROTAC Linkers
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Others
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NH2-PEG2000-NH2 is a polyethylene glycol derivative containing two primary amine groups. The amino group can react quickly with activated carboxylic acid or carboxyl groups such as NHS esters to form stable amide bonds. The PEGylation of NH2-PEG-NH2 can increase solubility and stability, and reduce the immunogenicity of peptides and proteins, so it is mostly used to modify proteins, peptides and other substances.
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- HY-168940B
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Drug Intermediate
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Cancer
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NH2-PEG2000-COOH is a heterofunctional polyethylene glycol with one amino terminal group and one carboxyl terminal group. NH2-PEG2000-COOH reacts with N-succinimidyl-6-maleimidohexanoate to introduce a maleimide terminal group, followed by conjugation with thiolated RGD peptide via a thiol-maleimide coupling reaction to synthesize RGD-PEG-COOH. NH2-PEG2000-COOH can be used in cancer research .
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- HY-P10392AF
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Wnt
β-catenin
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Cancer
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fStAx-35R TFA is the hydrocarbon-stapled peptide. fStAx-35R TFA inhibits Wnt/β-catenin signaling pathway by disrupting the β-catenin-TCF interaction. fStAx-35R TFA can be used in cancer research .
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- HY-168937
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PROTAC Linkers
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Others
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HS-PEG2000-NH2 hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .
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- HY-P10896
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Bombesin Receptor
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Cancer
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NOTA-P2-RM26 is an antagonist of Bombesin (HY-P0195) analogs, and the gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for prostate cancer visualization. NOTA-P2-RM26 is labeled with 111In and 68Ga for prostate cancer imaging studies using PET and SPECT/CT .
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- HY-140007
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PROTAC Linkers
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Cancer
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Acrylate-PEG2000-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-169232
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PROTACs
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Cancer
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PCC16 chloride is a CRBN-based cp-PCC with an IC50 value of 102 nM for the degradation of DHHC3. PCC16 chloride has antitumor activity. (Target protein ligand: HY-169235, linker: HY-169236, E3 ligase ligand: HY-10984) .
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- HY-W598230A
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Biochemical Assay Reagents
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Others
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m-PEG2000-NH2 hydrochloride is a barrier permeation compound involved in the preparation of hybrid gels with adsorption and size exclusion chromatography (AdSEC) properties. m-PEG-NH2 helps AdSEC gels separate from complex biological mixtures such as blood, urine, sweat, and tears.
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- HY-174359A
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Biochemical Assay Reagents
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Others
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Alkyne-PEG2000-NH2 is an alkyne-functionalized bifunctional PEG derivative that can be used to modify proteins, peptides, and other materials. The alkyne group reacts with azides in aqueous solution in a copper-catalyzed manner. PEGylation can increase solubility and stability and reduce the immunogenicity of peptides and proteins .
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- HY-174902C
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- HY-W591986A
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Biochemical Assay Reagents
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Others
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HO-PEG2000-NH2 is a polyethylene glycol derivative containing an amino group. HO-PEG2000-NH2 can be used in biochemical research .
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- HY-W1052215A
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Folate-PEG2000-NH2
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Biochemical Assay Reagents
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Others
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FA-PEG2000-NH2 (Folate-PEG2000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
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- HY-W1052523
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Biochemical Assay Reagents
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Others
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DPPE-PEG2000-NH2 is a conjugate composed of DPPE, a PEG chain, and a terminal primary amino group (-NH2). The primary amino group in DPPE-PEG2000-NH2 can be covalently linked to functional groups such as carboxylic acids, NHS esters, and isocyanates for targeted modification of liposomes/nanoparticles.
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- HY-W1051916A
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Biochemical Assay Reagents
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Others
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NH2-PEG2000-DBCO is a compound composed of an amino group, PEG, and DBCO, and can be used for drug delivery. NH2-PEG2000-DBCO contains clickable functional groups DBCO and PEG, and can undergo a ring-strain-driven acetylene-azide cycloaddition reaction (SPAAC) with molecules containing an azide group.
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- HY-W1052298
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DMPE-PEG2000-Amine
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Biochemical Assay Reagents
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Others
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DMPE-PEG2000-NH2 (DMPE-PEG2000-Amine) is a conjugate composed of DMPE, a PEG chain, and a terminal primary amino group (-NH2). The primary amino group in DMPE-PEG2000-NH2 can be covalently linked to functional groups such as carboxylic acids, NHS esters, and isocyanates for targeted modification of liposomes/nanoparticles.
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- HY-W1052298D
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DMPE-PEG10000-Amine
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Biochemical Assay Reagents
|
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DMPE-PEG2000-NH2 (DMPE-PEG2000-Amine) is a conjugate composed of DMPE, a PEG chain, and a terminal primary amino group (-NH2). The primary amino group in DMPE-PEG2000-NH2 can be covalently linked to functional groups such as carboxylic acids, NHS esters, and isocyanates for targeted modification of liposomes/nanoparticles.
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- HY-D2895C
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Rhodamine B-PEG2000-NH2
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Fluorescent Dye
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Others
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RB-PEG2000-NH2 (Rhodamine B-PEG2000-NH2) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and an amino group. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds (Ex/Em=546/610 nm) .
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- HY-183015A
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Biochemical Assay Reagents
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Others
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Mannose-PEG2000-NH2 is composed of mannose, PEG chains, and terminal amino groups (–NH2). Mannose-PEG-NH2 combines the targeting recognition ability of mannose with the chemical modifiability of amino groups, making it suitable for applications such as targeted drug delivery systems and nanoparticle modification.
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- HY-W1048547A
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HOOC-PEG2000-Amine
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Biochemical Assay Reagents
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Others
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HOOC-PEG2000-NH2 (HOOC-PEG2000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-P11625
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RXFP Receptor
|
Cardiovascular Disease
|
|
R9-13 is a fatty acid-conjugated relaxin and an agonist of LGR7 (RXFP1). R9-13 induces sustained pubic symphysis elongation in estrogen-pretreated mice. R9-13 exhibits long-acting pharmacokinetic profiles in rodents, with in vivo activity lasting up to one week after administration. R9-13 can be used in studies related to acute heart failure .
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- HY-P11830
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Amylin Receptor
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Metabolic Disease
|
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UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity .
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- HY-P11596
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Integrin
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Cancer
|
|
NOTA-Asp2-αvβ6L is an integrin αvβ6 binder with selective accumulation in αvβ6-positive pancreatic cancer cells and tumors. NOTA-Asp2-αvβ6L can be used as a PET/CT tracer for imaging pancreatic ductal adenocarcinoma (PDAC) .
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- HY-P3252AS
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Isotope-Labeled Compounds
Complement System
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Inflammation/Immunology
|
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Pegcetacoplan- 13C3, 15N TFA is the 13C- and 15N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D2895C
-
|
Rhodamine B-PEG2000-NH2
|
Fluorescent Dyes
|
|
RB-PEG2000-NH2 (Rhodamine B-PEG2000-NH2) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and an amino group. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds (Ex/Em=546/610 nm) .
|
| Cat. No. |
Product Name |
Type |
-
- HY-168940B
-
|
|
Biochemical Assay Reagents
|
|
NH2-PEG2000-COOH is a heterofunctional polyethylene glycol with one amino terminal group and one carboxyl terminal group. NH2-PEG2000-COOH reacts with N-succinimidyl-6-maleimidohexanoate to introduce a maleimide terminal group, followed by conjugation with thiolated RGD peptide via a thiol-maleimide coupling reaction to synthesize RGD-PEG-COOH. NH2-PEG2000-COOH can be used in cancer research .
|
-
- HY-168937
-
|
|
Biochemical Assay Reagents
|
|
HS-PEG2000-NH2 hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .
|
-
- HY-W598230A
-
|
|
Biochemical Assay Reagents
|
|
m-PEG2000-NH2 hydrochloride is a barrier permeation compound involved in the preparation of hybrid gels with adsorption and size exclusion chromatography (AdSEC) properties. m-PEG-NH2 helps AdSEC gels separate from complex biological mixtures such as blood, urine, sweat, and tears.
|
-
- HY-174359A
-
|
|
Biochemical Assay Reagents
|
|
Alkyne-PEG2000-NH2 is an alkyne-functionalized bifunctional PEG derivative that can be used to modify proteins, peptides, and other materials. The alkyne group reacts with azides in aqueous solution in a copper-catalyzed manner. PEGylation can increase solubility and stability and reduce the immunogenicity of peptides and proteins .
|
-
- HY-174902C
-
|
OPSS-PEG2000-NH2
|
Biochemical Assay Reagents
|
|
PDP-PEG2000-NH2 (OPSS-PEG2000-NH2) is a PEG derivative that can be used for drug delivery research .
|
-
- HY-W1052215A
-
|
Folate-PEG2000-NH2
|
Biochemical Assay Reagents
|
|
FA-PEG2000-NH2 (Folate-PEG2000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
|
-
- HY-W1052523
-
|
|
Biochemical Assay Reagents
|
|
DPPE-PEG2000-NH2 is a conjugate composed of DPPE, a PEG chain, and a terminal primary amino group (-NH2). The primary amino group in DPPE-PEG2000-NH2 can be covalently linked to functional groups such as carboxylic acids, NHS esters, and isocyanates for targeted modification of liposomes/nanoparticles.
|
-
- HY-W1051916A
-
|
|
Biochemical Assay Reagents
|
|
NH2-PEG2000-DBCO is a compound composed of an amino group, PEG, and DBCO, and can be used for drug delivery. NH2-PEG2000-DBCO contains clickable functional groups DBCO and PEG, and can undergo a ring-strain-driven acetylene-azide cycloaddition reaction (SPAAC) with molecules containing an azide group.
|
-
- HY-W1052298
-
|
DMPE-PEG2000-Amine
|
Biochemical Assay Reagents
|
|
DMPE-PEG2000-NH2 (DMPE-PEG2000-Amine) is a conjugate composed of DMPE, a PEG chain, and a terminal primary amino group (-NH2). The primary amino group in DMPE-PEG2000-NH2 can be covalently linked to functional groups such as carboxylic acids, NHS esters, and isocyanates for targeted modification of liposomes/nanoparticles.
|
-
- HY-W1052298D
-
|
DMPE-PEG10000-Amine
|
Biochemical Assay Reagents
|
|
DMPE-PEG2000-NH2 (DMPE-PEG2000-Amine) is a conjugate composed of DMPE, a PEG chain, and a terminal primary amino group (-NH2). The primary amino group in DMPE-PEG2000-NH2 can be covalently linked to functional groups such as carboxylic acids, NHS esters, and isocyanates for targeted modification of liposomes/nanoparticles.
|
-
- HY-183015A
-
|
|
Biochemical Assay Reagents
|
|
Mannose-PEG2000-NH2 is composed of mannose, PEG chains, and terminal amino groups (–NH2). Mannose-PEG-NH2 combines the targeting recognition ability of mannose with the chemical modifiability of amino groups, making it suitable for applications such as targeted drug delivery systems and nanoparticle modification.
|
-
- HY-W1048547A
-
|
HOOC-PEG2000-Amine
|
Biochemical Assay Reagents
|
|
HOOC-PEG2000-NH2 (HOOC-PEG2000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10392AF
-
|
|
Wnt
β-catenin
|
Cancer
|
|
fStAx-35R TFA is the hydrocarbon-stapled peptide. fStAx-35R TFA inhibits Wnt/β-catenin signaling pathway by disrupting the β-catenin-TCF interaction. fStAx-35R TFA can be used in cancer research .
|
-
- HY-P10896
-
|
|
Bombesin Receptor
|
Cancer
|
|
NOTA-P2-RM26 is an antagonist of Bombesin (HY-P0195) analogs, and the gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for prostate cancer visualization. NOTA-P2-RM26 is labeled with 111In and 68Ga for prostate cancer imaging studies using PET and SPECT/CT .
|
-
- HY-169232
-
|
|
PROTACs
|
Cancer
|
|
PCC16 chloride is a CRBN-based cp-PCC with an IC50 value of 102 nM for the degradation of DHHC3. PCC16 chloride has antitumor activity. (Target protein ligand: HY-169235, linker: HY-169236, E3 ligase ligand: HY-10984) .
|
-
- HY-P11625
-
|
|
RXFP Receptor
|
Cardiovascular Disease
|
|
R9-13 is a fatty acid-conjugated relaxin and an agonist of LGR7 (RXFP1). R9-13 induces sustained pubic symphysis elongation in estrogen-pretreated mice. R9-13 exhibits long-acting pharmacokinetic profiles in rodents, with in vivo activity lasting up to one week after administration. R9-13 can be used in studies related to acute heart failure .
|
-
- HY-P11830
-
|
|
Amylin Receptor
|
Metabolic Disease
|
|
UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity .
|
-
- HY-P11596
-
|
|
Integrin
|
Cancer
|
|
NOTA-Asp2-αvβ6L is an integrin αvβ6 binder with selective accumulation in αvβ6-positive pancreatic cancer cells and tumors. NOTA-Asp2-αvβ6L can be used as a PET/CT tracer for imaging pancreatic ductal adenocarcinoma (PDAC) .
|
-
- HY-P3252AS
-
|
|
Isotope-Labeled Compounds
Complement System
|
Inflammation/Immunology
|
|
Pegcetacoplan- 13C3, 15N TFA is the 13C- and 15N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).
|
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-P3252AS
-
|
|
|
Pegcetacoplan- 13C3, 15N TFA is the 13C- and 15N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).
|
-
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