2. GPCR/G Protein
  3. Amylin Receptor
  4. UDA-6

UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity.

For research use only. We do not sell to patients.

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UDA-6

UDA-6 Chemical Structure

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UDA-6 Related Antibodies

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Description

UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity[1].

In Vitro

UDA-6 (30 min) potently and equally activates human AMY3R and human CTR in HEK-293 cells, with EC50 values of 0.8 pM and 0.6 pM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UDA-6 Related Antibodies
Parmacokinetics
Species Dose Route AUC0-inf AUC0-t T1/2 CL MRT0-inf Vdss Tmax Cmax Bioavailability
Rat[1] 1.0 mg/kg i.v. 142.9 μg·h/mL 142.3 μg·h/mL 15.5 h 7.0 mL/h/kg 21.9 h 0.153 L/kg / / /
Rat[1] 3.0 mg/kg s.c. 282.7 μg·h/mL 281.1 μg·h/mL 15.6 h / / / 8 h 6.8 μg/mL 65.9 %
In Vivo

UDA-6 (1-30 nmol/kg; s.c.; single dose) elicits potent, dose-dependent, sustained reductions in body weight and food intake in lean SD rats[1].
UDA-6 (10-20 nmol/kg; s.c.; daily; 24 days) induces body weight decrease and improves metabolic and hepatic parameters in male DIO SD rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lean SD Rats (male, 8-10 weeks old)[1]
Dosage: 1; 3; 10; 30 nmol/kg
Administration: s.c.; single dose
Result: Produced a dose-dependent reduction in body weight and cumulative food intake over 96 hours.
Caused transient food intake inhibition over 24 hours followed by rebound at 1 nmol/kg.
Induced a >10% decrease in body weight relative to vehicle controls and sustained food intake suppression over 48 hours at 30 nmol/kg.
Showed no signs of discomfort, emesis, or behavioral abnormalities at any dose.
Animal Model: DIO SD Rats (male, 600-700 g) maintained on a high fat diet (HFD).[1]
Dosage: 10 ; 20 nmol/kg
Administration: s.c.; daily; 24 days
Result: Resulted in a maximum mean body weight decrease of 13.1% from baseline at 20 nmol/kg.
Reduced ad libitum fed blood glucose levels, serum AST, ALT, TG, TC, and fasting blood glucose levels relative to vehicle controls.
Reduced liver weight, hepatic TG, and hepatic TC.
Partially alleviated liver inflammation and lipid deposition via oil red O and H&E staining.
Molecular Weight

4341.87

Formula

C193H315N51O62
Sequence

{Pyr}-Ser-His-Leu-Ser-Thr-Ala-Val-Leu-Gly-Arg-cyclo{Lys-(PEG2-Gly-Gly-Ser-Gly-Ser-Gly-γGlu-C20 diacid)-Ser-Ala-Glu-Glu}-His-Lys-Leu-{Aib}-Asp-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ser-Gly-Ala-Pro-NH2
Sequence Shortening

{Pyr}-SHLSTAVLGR-cyclo{K-(PEG2-GGSGSG-γGlu-C20 diacid)-SAEE}-HKL-{Aib}-DYPRTDVGSGAP-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UDA-6 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UDA-6UDA6UDA 6Amylin ReceptorAMYRobesitylean male SD ratsmetabolic parameterscalcitonin receptorhuman AMY3Rmale DIO SD ratshepatic parametersamylin receptorhuman CTRHEK-293 cellsInhibitorinhibitorinhibit

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