NH2-PEG2000-COOH
Based on 1 Customer Validation
NH2-PEG5000-COOH is a compound composed of an NH2 group, PEG units (MW = 2000) and a carboxyl group (-COOH). NH2-PEG-COOH is widely used for surface modification and functionalization of polymer carriers or nanoparticles.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 139729-28-5
- Molecular Weight:2000 (Average)
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NH2-PEG-COOH is directly grafted onto the surface of PPI dendrimers via amide bonds, and the resulting modified vector reduces in vitro cytotoxicity, diminishes the sub-G1 apoptotic peak, and enhances gene transfection efficiency in neuroblastoma cells[1].
NH2-PEG3400-COOH can serve as a coupling unit for constructing PLGA-PEG-COOH copolymers, enabling PEGylation of the surface of NPs while retaining terminal -COOH groups for conjugation with targeting molecules[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 139729-28-5
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Appearance Solid
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Molecular Weight 2000 (Average)
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Color White to off-white
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SMILES
OC(COCCN)=O.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : ≥ 100 mg/mL
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hashemi M, et al.. PEGylation of Polypropylenimine Dendrimer with Alkylcarboxylate Chain Linkage to Improve DNA Delivery and Cytotoxicity. Applied biochemistry and biotechnology. 2015 Sep;177(1):1-17. [Content Brief]
[2]. Betancourt T, et al.. PEGylation strategies for active targeting of PLA/PLGA nanoparticles. Journal of biomedical materials research. Part A. 2009 Oct;91(1):263-76. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NH2-PEG2000-COOH Related Classifications
HY-168940B Related Classifications
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