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Cat. No.: HY-169232

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PCC16 chloride

PCC16 chloride is a CRBN-based cp-PCC with an IC₅₀ value of 102 nM for the degradation of DHHC3. PCC16 chloride has antitumor activity.
(Pink: DHHC3 ligand (HY-169235); Blue: Cereblon ligand (HY-10984); Black: linker (HY-169236)).

For research use only. We do not sell to patients.

Formula: C₂₀₆H₃₂₂ClN₆₇O₆₀S
Molecular Weight:4764.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PCC16 chloride Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PCC16 chloride is a CRBN-based cp-PCC with an IC₅₀ value of 102 nM for the degradation of DHHC3. PCC16 chloride has antitumor activity^[1]. (Pink: DHHC3 ligand (HY-169235); Blue: Cereblon ligand (HY-10984); Black: linker (HY-169236)).

All PROTACs Isoforms :

Chemical Information

Molecular Weight 4764.69
Formula C₂₀₆H₃₂₂ClN₆₇O₆₀S
Sequence

{Rhodmine B}-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Gly-Ile-Gln-Asp-Thr-Asn-Ser-Lys-Lys-Gln-Ser-Asp-Thr-His-Leu-Glu-Glu-Thr-{Lys(pomalidomide-Suc-PEG2)}-NH2
Sequence Shortening

{Rhodmine B}-YGRKKRRQRRRCGIQDTNSKKQSDTHLEET-{Lys(pomalidomide-Suc-PEG2)}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shi YY, et al. Treating ICB-resistant cancer by inhibiting PD-L1 via DHHC3 degradation induced by cell penetrating peptide-induced chimera conjugates. Cell Death Dis. 2024 Sep 30;15(9):701. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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