Pegcetacoplan-13C3,15N TFA
Based on 1 publication(s) in Google Scholar
Pegcetacoplan-13C3,15N TFA is the 13C- and 15N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).
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- Fòrmula: (C2H4O)nC170H248N50O47S4·xC2HF3O2
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Pegcetacoplan-13C3,15N TFA
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Actividad biológica
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Fòrmula (C2H4O)nC170H248N50O47S4·xC2HF3O2
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Sequence
Ac-Ile-Cys-Val-Trp(Me)-Gln-Asp-Trp-Gly-Ala(13C3,15N)-His-Arg-Cys-Thr-PEG2-Lys-NH2(Cys and Cys bridge,Dimer with PEG40000)
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Sequence Shortening
Ac-ICV-{Trp(Me)}-QDWG-{Ala(13C3,15N)}-HRCY-PEG2-K-NH2(Cys and Cys bridge,Dimer with PEG40000)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
Complement receptor 3 (CR3)-dependent microglial synapse elimination drives Parkinson's disease pathogenesis in systemic inflammation. [Abstract]2026 Mar 25;17(1):319. PMID: 41881908
Pureza y Documentación
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)