Ouabain Octahydrate

By Targets:	Adrenergic Receptor (2) Biochemical Assay Reagents (1) Calcium Channel (1) COX (1) Drug Metabolite (1) Endogenous Metabolite (2) Fluorescent Dye (2) Interleukin Related (1) MOFs (1) Na+/K+ ATPase (4) Nucleoside Antimetabolite/Analog (1) Phosphodiesterase (PDE) (1) Reference Standards (1) RSV (2) TNF Receptor (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (8) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Inosine Nucleoside (1) Nucleotide Analogs (1)

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-D0085

DiSC3(5) 10+ Cited Publications	Fluorescent Dye	Cancer
DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3(5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .

HY-12283

Rostafuroxin 2 Publications Verification PST 2238	Na+/K+ ATPase RSV	Cardiovascular Disease
Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na ⁺,K ⁺-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity .

HY-W040188

Fosfructose trisodium octahydrate	Biochemical Assay Reagents	Others
Fosfructose trisodium octahydrate is a phosphorylated sugar derivative used in biochemical research and is also an intermediate in carbohydrate metabolism.

HY-W010759

Inosine-5′-monophosphate disodium salt octahydrate	Endogenous Metabolite	Metabolic Disease
Inosine-5'-monophosphate disodium salt octahydrate is a purine nucleotide that can be used as an umami tastant as well as a precursor of GMP and AMP .

HY-DY1021

DiSC3(5) (solution)	Fluorescent Dye	Others
DiSC3 (5) (solution) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3 (5) is up to 622/670 nm. DiSC3 (5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3 (5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells . Solvent and concentration: DMSO: 1 mM The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-135000

Decarbamoylsaxitoxin DcSTX; DecarbamoylSTX	Endogenous Metabolite Drug Metabolite	Neurological Disease
Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na ⁺ channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning .

HY-163162

Anhydro-Ouabain	Interleukin Related TNF Receptor	Neurological Disease Inflammation/Immunology
Anhydro-Ouabain (compound 20) is a cardiotonic steroid which shows anti-inflammatory and neuroprotective activities and thus can be used in neurological research .

HY-106831

R 56865	Calcium Channel	Cardiovascular Disease
R 56865 is a cardiomyocyte protective agent that protects against digitoxin (Ouabain)-induced myocardial calcium overload. R 56865 has a protective effect against digitoxin-induced intoxication in guinea pig papillary muscle .

HY-43441A

Cyclohexane-1,2,3,4,5,6-hexaone octahydrate Triquinoyl Octahydrate	MOFs	Others
Cyclohexane-1,2,3,4,5,6-hexaone octahydrate(Triquinoyl octahydrate) is a metal-organic framework (MOF).

HY-N3167

Nyasicoside	Nucleoside Antimetabolite/Analog	Cardiovascular Disease
Nyasicoside is a norlignan glucosides that can be isolated from Curculigo capitulate. Nyasicoside has potent activity against ouabain-induced arrhythmia in the heart preparations of guinea pig .

HY-129733

LND 623	Na+/K+ ATPase	Cardiovascular Disease
LND 623 is an inotropic aminosteroid with positive inotropic properties. LND 623 inhibits Na ⁺/K ⁺ ATPase activity. The LD₅₀ of LND 623 infused i.v. is around 45 mg/kg, a value ten times higher than the LD₅₀ for Ouabain (HY-B1457) .

HY-12283R

Rostafuroxin (Standard) PST 2238 (Standard)	Na+/K+ ATPase RSV Reference Standards	Cardiovascular Disease
Rostafuroxin (Standard) is the analytical standard of Rostafuroxin. This product is intended for research and analytical applications. Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity .

HY-121312

Flutonidine ST-600	Adrenergic Receptor	Cardiovascular Disease
Flutonidine (ST-600) is a Clonidine (HY-12721) analogue that shows antihypertensive and sympatholytic effects. The initial hypertension produced by Flutonidine is due to stimulation of the peripheral α1, α2 adrenoceptors and the subsequent fall in blood pressure is due to the stimulation of central α2 adrenoceptors. Flutonidine reduces the arrhythmogenic and lethal effects of ouabain. Flutonidine is promising for research of ventricular arrhythmias caused by cardiac glycosides .

HY-19091

ICI-170777	Phosphodiesterase (PDE) Adrenergic Receptor COX	Cardiovascular Disease
ICI-170777 is an orally active cardiotonic agent and type III Phosphodiesterase inhibitor, with an IC₅₀ of 2.5 μM against cyclic AMP phosphodiesterase type III from canine cardiac fractions. ICI-170777 inhibits Aldrin epoxidase and pentobarbital metabolism. It enhances β-adrenergic receptor-mediated positive inotropic effects without causing chronotropic effects, while also exerting balanced arteriolar/venular vasodilator, platelet aggregation inhibitor and smooth muscle relaxant activities. ICI-170777 restores cardiac function in an acute canine heart failure model, exhibits additive effects when combined with Ouabain (HY-B1457), and shows no significant activity against multiple receptor classes or non-cardiac systems. ICI-170777 can be used in research related to congestive heart failure .

HY-165443

Cassaine Nervocidine	Na+/K+ ATPase	Cardiovascular Disease
Cassaine (Nervocidine) is a Na ⁺/K ⁺-ATPase inhibitor. Cassaine stabilizes phosphorylated intermediates, slows spontaneous dephosphorylation and blocks potassium-stimulated dephosphorylation. Cassaine exhibits non-competitive inhibition with respect to K ⁺, shows inhibition enhanced by Pi and antagonized by Na ⁺. Cassaine induces positive inotropic effects in perfused hearts with faster inotropy offset. Cassaine can be used for research on cardiac arrhythmias .

Cat. No.	Nombre del producto	Type

HY-D0085

DiSC3(5) 10+ Cited Publications	Fluorescent Dyes
DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3(5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .

DiSC3(5)

10+ Cited Publications

Fluorescent Dyes

DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3(5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .

HY-DY1021

DiSC3(5) (solution)	Fluorescent Dyes
DiSC3 (5) (solution) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3 (5) is up to 622/670 nm. DiSC3 (5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3 (5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells . Solvent and concentration: DMSO: 1 mM The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

DiSC3(5) (solution)

Fluorescent Dyes

DiSC3 (5) (solution) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3 (5) is up to 622/670 nm. DiSC3 (5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3 (5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .
Solvent and concentration: DMSO: 1 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cat. No.	Nombre del producto	Type

HY-W040188

Fosfructose trisodium octahydrate	Biochemical Assay Reagents
Fosfructose trisodium octahydrate is a phosphorylated sugar derivative used in biochemical research and is also an intermediate in carbohydrate metabolism.

HY-W010759

Inosine-5′-monophosphate disodium salt octahydrate	Biochemical Assay Reagents
Inosine-5'-monophosphate disodium salt octahydrate is a purine nucleotide that can be used as an umami tastant as well as a precursor of GMP and AMP .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-135000

Decarbamoylsaxitoxin DcSTX; DecarbamoylSTX	Structural Classification Productos naturales Microorganisms Source Classification	Endogenous Metabolite Drug Metabolite
Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na ⁺ channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning .

HY-N3167

Nyasicoside	Curculigo orchioides Gaertn. Phenols Polyphenols Plants Amaryllidaceae Source Classification	Nucleoside Antimetabolite/Analog
Nyasicoside is a norlignan glucosides that can be isolated from Curculigo capitulate. Nyasicoside has potent activity against ouabain-induced arrhythmia in the heart preparations of guinea pig .

HY-165443

Cassaine Nervocidine	Structural Classification Erythrophleum suaveolens (Guill. et Perr.) Brenan Terpenoids Diterpenoids Plants Fabaceae Source Classification	Na+/K+ ATPase
Cassaine (Nervocidine) is a Na ⁺/K ⁺-ATPase inhibitor. Cassaine stabilizes phosphorylated intermediates, slows spontaneous dephosphorylation and blocks potassium-stimulated dephosphorylation. Cassaine exhibits non-competitive inhibition with respect to K ⁺, shows inhibition enhanced by Pi and antagonized by Na ⁺. Cassaine induces positive inotropic effects in perfused hearts with faster inotropy offset. Cassaine can be used for research on cardiac arrhythmias .

Cat. No.	Nombre del producto		Classification

HY-W010759

Inosine-5′-monophosphate disodium salt octahydrate		Nucleotide Analogs Inosine Nucleoside
Inosine-5'-monophosphate disodium salt octahydrate is a purine nucleotide that can be used as an umami tastant as well as a precursor of GMP and AMP .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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Ouabain Octahydrate

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

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