2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite Drug Metabolite
  4. Decarbamoylsaxitoxin

Decarbamoylsaxitoxin  (Synonyms: DcSTX; DecarbamoylSTX)

Cat. No.: HY-135000
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Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na+ channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning.

For research use only. We do not sell to patients.

Decarbamoylsaxitoxin

Decarbamoylsaxitoxin Chemical Structure

CAS No. : 58911-04-9

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Decarbamoylsaxitoxin Related Antibodies

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Description

Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na+ channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning[1][2].

In Vitro

Decarbamoylsaxitoxin (200-1000 pg/well, 3 nM to 300 μM; 8-24 hr) inhibits ouabain/veratridine-induced cell lysis in mouse neuroblastoma cells (ATCC no. CCL 131) with a mean relative toxicity of 42.6% compared to US FDA saxitoxin standard[2].
Decarbamoylsaxitoxin (110 μg/mL; 5 min boiled in 0.1 N or 1.0 N HCl) remains stable (toxicity unchanged) after boiling for 5 min in either 0.1 N or 1.0 N HCl, as measured in mouse neuroblastoma cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Decarbamoylsaxitoxin Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: mouse neuroblastoma cells (ATCC no. CCL 131)
Concentration: 200-1000 pg/well; 3 nM to 300 μM (tested immediately after opening sealed ampoules)
Incubation Time: 8-24 hr
Result: Exhibited a dose-response profile in the neuroblastoma cell bioassay, with mean relative toxicity of 42.6% compared to US FDA saxitoxin standard (set at 100%).
Showed overlapping dose-response profile shape with GTX II/III-1.
Increased absorbance values of adherent stained cells with higher decarbamoylsaxitoxin concentrations.
Molecular Weight

256.26

Formula

C9H16N6O3
CAS No.
SMILES

OC1([C@]23[C@](N=C(N3)N)([H])[C@@H](N=C(N2CC1)N)CO)O
Structure Classification
Initial Source

Gonyaulax catenella
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Decarbamoylsaxitoxin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Decarbamoylsaxitoxin58911-04-9DcSTX DecarbamoylSTXEndogenous MetaboliteDrug Metabolitesaxitoxin receptorsodium channelsodium ionsouabainparalytic shellfish poisoningaction potentialveratridinenerve membranesmouse neuroblastoma cellskeletal muscle membranesInhibitorinhibitorinhibit

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