PCI

By Targets:	Antibiotic (2) Apoptosis (1) Bacterial (3) BCRP (1) Btk (10) Complement System (1) Factor VIIa (1) Fluorescent Dye (2) Fungal (1) HDAC (2) Isotope-Labeled Compounds (1) Ligands for Target Protein for PROTAC (2) Reference Standards (3) Serpin (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (13) Infection (4) Inflammation/Immunology (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10997

Ibrutinib Maximum Cited Publications 126 Publications Verification PCI-32765	Btk Ligands for Target Protein for PROTAC	Infection Inflammation/Immunology Cancer
Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-15224

PCI-34051 25+ Cited Publications	HDAC Apoptosis	Cancer
PCI-34051 is a potent and selective HDAC8 inhibitor with IC₅₀ of 10 nM, with >200-fold selectivity over the other HDAC isoforms.

HY-10990

Abexinostat 5+ Cited Publications CRA 024781; PCI-24781	HDAC	Cancer
Abexinostat (CRA 024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with K_i of 7 nM. Abexinostat also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC₅₀ below 10 nM .

HY-16382

PCI-27483 1 Publications Verification	Factor VIIa	Cancer
PCI-27483 is a FVIIa/tissue factor inhibitor, with antitumour effects.

HY-100335

PCI-33380 1 Publications Verification	Fluorescent Dye Btk	Cancer
PCI-33380 is a fluorescent probe ( (Ex=532 nm, Em=555 nm). PCI-33380 consists of a (BTK) inhibitor PCI-32765 (HY-10997) attaching with a Bodipy-FL fluorophore via a piperazine linker. PCI-33380 binds predominantly to Btk in B cell lysates with cell permeable activity. PCI-33380 can be used for imaging live cancer cells such as non-Hodgkin lymphoma research

HY-10997A

Ibrutinib Racemate 1 Publications Verification PCI-32765 Racemate	Btk	Cancer
Ibrutinib Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC₅₀ value of 0.5 nM.

HY-100659

Dihydrodiol-Ibrutinib PCI-45227	Btk	Cancer
Dihydrodiol-Ibrutinib (PCI-45227) is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib .

HY-10997R

Ibrutinib (Standard) PCI-32765 (Standard)	Reference Standards Btk Ligands for Target Protein for PROTAC	Cancer
Ibrutinib (Standard) is the analytical standard of Ibrutinib. This product is intended for research and analytical applications. Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-N3346

Macrocarpal A 10-epi-Eucarobustol F	Bacterial	Infection
Macrocarpal A (10-epi-Eucarobustol F) is an antibacterial agent, which can be isolated from the leaves of Eucalyptus macrocarpa. Macrocarpal A inhibits the growth of Bacillus subtilis PCI219 (minimum inhibitory concentration below 0.2 µM) and Staphylococcus aureus FDA209P (minimum inhibitory concentration is 0.4 µM) .

HY-18010

PCI 29732 3 Publications Verification	Btk BCRP	Inflammation/Immunology
PCI 29732 is a potent, orally active, reversible BTK inhibitor with K_i ^app values of 8.2, 4.6, and 2.5 nM for BTK, Lck and Lyn, respectively. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase. PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 .

HY-10997S

Ibrutinib-d5 PCI-32765-d₅	Btk	Cancer
Ibrutinib-d₅ (PCI-32765-d₅) is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor .

HY-100659S

Dihydrodiol-Ibrutinib-d5 PCI-45227-d₅	Btk Isotope-Labeled Compounds	Cancer
Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib (HY-100659). Dihydrodiol-Ibrutinib is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib .

HY-N16374

Mazethramycin B	Antibiotic Bacterial Fungal	Infection Cancer
Mazethramycin B (Compound II) is an antitumor antibiotic. Mazethramycin B can be isolated from the Streptomyces thioluteusM ME561-L4. Mazethramycin B has a broad-spectrum antimicrobial activity (such as MICs of 1.56 and 6.25 μg/mL for the bacteria Bacillus subtilis PCI 219 and the fungus Candida pseudotropicalis, resepectively). Mazethramycin B significantly increases survival in L1210 leukemia mice model .

HY-16384

L-156602 Antibiotic L 156602; PD 124966	Complement System	Inflammation/Immunology
L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH) .

HY-10997AR

Ibrutinib Racemate (Standard) PCI-32765 Racemate (Standard)	Btk Reference Standards	Cancer
Ibrutinib (Racemate) (Standard) is the analytical standard of Ibrutinib (Racemate). This product is intended for research and analytical applications. Ibrutinib Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM.

HY-RS12701

SERPINA5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SERPINA5 Human Pre-designed siRNA Set A contains three designed siRNAs for SERPINA5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SERPINA5 Human Pre-designed siRNA Set A SERPINA5 Human Pre-designed siRNA Set A

HY-100335R

PCI-33380 (Standard)	Fluorescent Dye Reference Standards Btk	Cancer
PCI-33380 (Standard) is the analytical standard of PCI-33380 (HY-100335). This product is intended for research and analytical applications. PCI-33380 is a fluorescent probe ( (Ex=532 nm, Em=555 nm). PCI-33380 consists of a (BTK) inhibitor PCI-32765 (HY-10997) attaching with a Bodipy-FL fluorophore via a piperazine linker. PCI-33380 binds predominantly to Btk in B cell lysates with cell permeable activity. PCI-33380 can be used for imaging live cancer cells such as non-Hodgkin lymphoma research

HY-P992288

*Anti-PCI* Antibody**	Serpin	Inflammation/Immunology
Anti-PCI Antibody is a monoclonal antibody that targets PCI. Anti-PCI Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PCI Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-RS24688

Serpina5 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Serpina5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Serpina5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Serpina5 Rat Pre-designed siRNA Set A Serpina5 Rat Pre-designed siRNA Set A

HY-RS18211

Serpina5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Serpina5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Serpina5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Serpina5 Mouse Pre-designed siRNA Set A Serpina5 Mouse Pre-designed siRNA Set A

HY-182535

Tuberactinomycin-O	Antibiotic Bacterial	Infection
Tuberactinomycin-O is a peptide antibiotic belonging to the tuberactinomycin family. Tuberactinomycin-O inhibits the growth of various bacteria, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Mycobacterium ATCC 607. Tuberactinomycin-O exhibits acute toxicity in male mice when administered intravenously. Tuberactinomycin-O can be used in the research of tuberculosis .

Cat. No.	Product Name

HY-KE7048

BspQ I
BspQ I is one of the endonucleases of Type IIs that recognize non-palindromic sequences and cut outside of the recognition sequence, and is commonly used in Golden Gate assembly. Isoschizomers: Sap I, Lgu I, PciS I.

Cat. No.	Product Name	Target	Research Area	Image

HY-P992288

*Anti-PCI* Antibody**	Serpin	Inflammation/Immunology
Anti-PCI Antibody is a monoclonal antibody that targets PCI. Anti-PCI Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PCI Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3346

Macrocarpal A 10-epi-Eucarobustol F	Eucalyptus macrocarpa Hook. Terpenoids Myrtaceae Diterpenoids Plants Source Classification	Bacterial
Macrocarpal A (10-epi-Eucarobustol F) is an antibacterial agent, which can be isolated from the leaves of Eucalyptus macrocarpa. Macrocarpal A inhibits the growth of Bacillus subtilis PCI219 (minimum inhibitory concentration below 0.2 µM) and Staphylococcus aureus FDA209P (minimum inhibitory concentration is 0.4 µM) .

HY-N16374

Mazethramycin B	Microorganisms Antibiotics Source Classification	Antibiotic Bacterial Fungal
Mazethramycin B (Compound II) is an antitumor antibiotic. Mazethramycin B can be isolated from the Streptomyces thioluteusM ME561-L4. Mazethramycin B has a broad-spectrum antimicrobial activity (such as MICs of 1.56 and 6.25 μg/mL for the bacteria Bacillus subtilis PCI 219 and the fungus Candida pseudotropicalis, resepectively). Mazethramycin B significantly increases survival in L1210 leukemia mice model .

Species:	Human (2) Mouse (1)
Tag:	SUMO (1) His (3)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72055

	Serpin A5 Protein, Mouse (sf9, His) Serpina5; PCI; Plasma serine protease inhibitor; Plasminogen activator inhibitor 3; PAI-3; PAI3; Protein C inhibitor; PCI; Serpin A5	Mouse	Sf9 insect cells
	Serpin A5 protein is a heparin-dependent serine protease inhibitor that controls proteolytic activity in body fluids. It binds irreversibly to the serine activation site, inactivating serine proteases and regulating intravascular and extravascular proteolysis. Serpin A5 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin A5 protein, expressed by sf9 insect cells , with N-10*His labeled tag.

HY-P70975

	Serpin A5 Protein, Human (HEK293, His) 2 Publications Verification Plasma Serine Protease Inhibitor; Acrosomal Serine Protease Inhibitor; Plasminogen Activator Inhibitor 3; PAI-3; PAI3; Protein C Inhibitor; PCI; Serpin A5; SERPINA5; PCI; PLANH3; PROCI	Human	HEK293
	Plasma serine protease inhibitor (SERPINA5) is a glycoproteins that inhibit serine proteases. SERPINA5 is involved in the regulation of intravascular and extravascular proteolytic activities, controls the sperm motility and fertilization and protect components of the genital tract. SERPINA5 also inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. Serpin A5 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A5 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71577

	EIF3M Protein, Human (His-SUMO) B5; B5 receptor; Dendritic cell protein; eIF3m; EIF3M_HUMAN; Eukaryotic translation initiation factor 3 subunit M; Fetal lung protein B5; FLJ29030; GA17; hfl B5; hFL-B5; PCI domain containing 1 (herpesvirus entry mediator); PCI domain-containing protein 1; PCID1; TANGO7	Human	E. coli
	The EIF3M protein is a component of the eIF-3 complex and promotes protein synthesis initiation (eg, mRNA recruitment, scanning, and ribosomal subunit attachment) (PubMed:17403899, PubMed:25849773). EIF3M Protein, Human (His-SUMO) is the recombinant human-derived EIF3M protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-10997S

Ibrutinib-d5
Ibrutinib-d₅ (PCI-32765-d₅) is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor .

HY-100659S

Dihydrodiol-Ibrutinib-d5
Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib (HY-100659). Dihydrodiol-Ibrutinib is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib .

Host:	Mouse (2)
Reactivity:	Human (2)
Application:	IHC-P (2) ICC/IF (2) FC (2)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88512

	SERPINA5 Antibody (YA8196) PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI	IHC-P, ICC/IF, FC	Human
	SERPINA5 Antibody (YA8196) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SERPINA5.

HY-P88512A

	SERPINA5 Antibody (YA8196)(PBS only) PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI	IHC-P, ICC/IF, FC	Human
	SERPINA5 Antibody (YA8196) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SERPINA5.

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Cat. No.	Product Name		Classification

HY-RS12701

SERPINA5 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SERPINA5 Human Pre-designed siRNA Set A contains three designed siRNAs for SERPINA5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24688

Serpina5 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Serpina5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Serpina5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18211

Serpina5 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Serpina5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Serpina5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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