Serpin
Serine protease inhibitors (Serpins)
Serine protease inhibitors (serpins) are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. Serpins can be divided into two categories. Clade A serpins include inflammatory response molecules such as SERPINA1 (antitrypsin), SERPINA3 (antichymotrypsin), SERPINA6 (corticosteroid-binding globulin), and SERPINA7 (thyroxine-binding globulin). Clade B includes inhibitory molecules such as SERPINB6(PI6), SERPINB9 (PI9), SERPINB3, (squamous cell carcinoma antigen-1), and SERPINB5 (maspin). Serines control crucial physiological processes, such as inflammation, coagulation, thrombosis and thrombolysis, and immune responses[1].
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Serpin Related Products (8)
Related Products (8)
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GSK716
0 ImagesSynonyms: A1AT modulator 1GSK716 (A1AT modulator 1) is an orally active Z α1-antitrypsin (Z-A1AT) inhibitor with a pIC50 of 8.3. GSK716 binds a cryptic Z α1-antitrypsin pocket, stabilizes monomeric folding intermediates, blocks polymerization, and increases monomer secretion. GSK716 acts on select sensitive α1-antitrypsin variants but fails to affect resistant variants. GSK716 can be used for the research of α1-antitrypsin deficiency and α1-antitrypsin deficiency-associated liver disease.
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Serpinin
0 ImagesSerpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects.
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Belcesiran sodium
0 ImagesCat. No.: HY-177619ASynonyms: DCR-S1459 sodiumBelcesiran is an alpha 1 antitrypsin (A1AT) inhibitor that acts by allowing the liver to synthesise the A1AT protein and pass it into the bloodstream.
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Belcesiran
0 ImagesCat. No.: HY-177619CAS No.: 2375562-54-0Synonyms: DCR-S1459Belcesiran, a siRNA, is an alpha 1 antitrypsin (A1AT) inhibitor that acts by allowing the liver to synthesise the A1AT protein and pass it into the bloodstream.
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Anti-PCI Antibody
0 ImagesCat. No.: HY-P992288
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Belcesiran sodium scrambled negative control
0 ImagesCat. No.: HY-177619BBelcesiran sodium scrambled negative control is the sequence scrambled negative control of Belcesiran sodium.
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Crovozalpon
0 ImagesCat. No.: HY-177075CAS No.: 2406205-67-0Crovozalpon (Compound 4) is an inhibitor of alplha-1-antitrypsin. Crovozalpon can be used as a prodrug. Crovozalpon can be studied in research for diseases associated with alplha-1-antitrypsin
