Serpin Inhibitor
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GSK716
0 ImagesSynonyms: A1AT modulator 1GSK716 (A1AT modulator 1) is an orally active Z α1-antitrypsin (Z-A1AT) inhibitor with a pIC50 of 8.3. GSK716 binds a cryptic Z α1-antitrypsin pocket, stabilizes monomeric folding intermediates, blocks polymerization, and increases monomer secretion. GSK716 acts on select sensitive α1-antitrypsin variants but fails to affect resistant variants. GSK716 can be used for the research of α1-antitrypsin deficiency and α1-antitrypsin deficiency-associated liver disease.
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Belcesiran sodium
0 ImagesCat. No.: HY-177619ASynonyms: DCR-S1459 sodiumBelcesiran is an alpha 1 antitrypsin (A1AT) inhibitor that acts by allowing the liver to synthesise the A1AT protein and pass it into the bloodstream.
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Belcesiran
0 ImagesCat. No.: HY-177619CAS No.: 2375562-54-0Synonyms: DCR-S1459Belcesiran, a siRNA, is an alpha 1 antitrypsin (A1AT) inhibitor that acts by allowing the liver to synthesise the A1AT protein and pass it into the bloodstream.
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Belcesiran sodium scrambled negative control
0 ImagesCat. No.: HY-177619BBelcesiran sodium scrambled negative control is the sequence scrambled negative control of Belcesiran sodium.
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Crovozalpon
0 ImagesCat. No.: HY-177075CAS No.: 2406205-67-0Crovozalpon (Compound 4) is an inhibitor of alplha-1-antitrypsin. Crovozalpon can be used as a prodrug. Crovozalpon can be studied in research for diseases associated with alplha-1-antitrypsin
