Tuberactinomycin-O
Tuberactinomycin-O is a peptide antibiotic belonging to the tuberactinomycin family. Tuberactinomycin-O inhibits the growth of various bacteria, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Mycobacterium ATCC 607. Tuberactinomycin-O exhibits acute toxicity in male mice when administered intravenously. Tuberactinomycin-O can be used in the research of tuberculosis.
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- CAS No.: 33137-73-4
- 화학식: C25H43N13O9
- 분자량:669.69
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
In Vitro
Tuberactinomycin-O (24 h) inhibits the growth of multiple bacterial strains in vitro, with the highest potency against Bacillus subtilis PCI 219 (MIC 3.2 mcg/mL) and Mycobacterium ATCC 607 (MIC 6.3 mcg/mL), and the lowest potency against Staphylococcus aureus FDA 209 P and Sarcina lutea ATCC 1001 (MIC 100 mcg/mL)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (male)[1]
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Dosage:/
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Administration:i.v.; single dose
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Result:Determined an acute median lethal dose (LD50) of 370 mg/kg.
Chemical Information
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CAS No. 33137-73-4
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분자량 669.69
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화학식 C25H43N13O9
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SMILES
O=C1[C@](NC(/C(NC([C@@H](NC([C@@H](NC([C@H](CN1)NC(C[C@@H](N)CCCN)=O)=O)CO)=O)CO)=O)=C/NC(N)=O)=O)([H])[C@]2([H])NC(N)=NCC2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Acute Systemic Toxicity Study
Acute systemic toxicity studies evaluate adverse effects occurring after a single exposure, or repeated exposure within a short acute window, and the main in vivo readouts are mortality, moribund condition, clinical signs, body-weight change, and gross pathological findings; acute oral toxicity methods were developed to replace classical LD50 testing with reduced-animal designs such as fixed-dose procedure, acute toxic class method, and up-and-down procedure. The fixed-dose procedure classifies acute toxicity by administering predefined dose levels and observing evident toxicity rather than using death as the primary endpoint, whereas the acute toxic class method uses sequential groups of three animals per step and the up-and-down procedure doses animals sequentially to estimate an LD50 with fewer animals than conventional LD50 testing.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tuberactinomycin-O Related Classifications
HY-182535 Related Classifications
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Keywords
- Tuberactinomycin-O
- 33137-73-4
- Antibiotic
- Bacterial
- Staphylococcus aureus
- human tubercle bacilli H37Rv
- Bacillus subtilis PCI 219
- tubercle bacilli
- Pseudomonas aeruginosa
- Escherichia coli
- Streptomyces griseoverticillatus var. tuberacticus
- male mice
- Sarcina lutea ATCC 1001
- Mycobacterium ATCC 607
- Inhibitor
- inhibitor
- inhibit