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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

Spleen tyrosine kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FLT3 (3) Syk (21) Apoptosis (1) Aurora Kinase (1) Caspase (1) Drug Isomer (1) ERK (2) GSK-3 (1) JAK (1) LRRK2 (1) NF-κB (1) NO Synthase (1) Prostaglandin Receptor (1) Reference Standards (1) Src (1) TREM receptor (1) VEGFR (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (14) Neurological Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: Syk Btk Pyk2 TNK1 Tyrosine Hydroxylase DYRK BRK FAK FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100867A

Mivavotinib monohydrochloride TAK-659 monohydrochloride; CB-659 monohydrochloride	Syk FLT3	Cancer
TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and *fms related tyrosine* kinase 3 (FLT3), with an IC₅₀** of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL) .

HY-15322

PRT062607 4 Publications Verification P505-15; PRT-2607; BIIB-057	Syk Apoptosis Caspase	Inflammation/Immunology Cancer
PRT062607 (P505-15; PRT-2607) is an orally active ATP-competitive Syk inhibitor with an IC₅₀ value of 1 nM, and exhibits at least 80-fold selectivity over other kinases. PRT062607 blocks B cell antigen receptor-mediated activation, Fcε receptor 1-mediated basophil degranulation and microglial phagocytosis, and induces caspase-dependent apoptosis and microglial death. PRT062607 inhibits tumor growth and peripheral nerve injury-induced mechanical allodynia, and prevents neuronal loss. PRT062607 can be used in research related to rheumatoid arthritis, chronic lymphocytic leukemia, non-Hodgkin's lymphoma, neurodegenerative diseases and neuropathic pain .

HY-178129

MRL-SYKi	Syk	Inflammation/Immunology
MRL-SYKi is a chemical probe for gain-of-function variants of spleen tyrosine kinase (SYK). MRL-SYKi reduces the catalytic activity of SYK ^S550Y, SYK ^S550F and SYK ^P342T, and downregulates the phosphorylation level of SYK ^S550Y. MRL-SYKi serves as a template for developing NanoBRET tracers targeting SYK, enabling NanoBRET cellular target engagement assays for gain-of-function variants of SYK. MRL-SYKi is applicable to research related to inflammatory and immune diseases .

HY-16420

R112	Syk	Inflammation/Immunology
R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC₅₀ value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis .

HY-109082

Cevidoplenib SKI-O-703	Syk	Inflammation/Immunology
Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC₅₀s of 6.2 nM (Syk), 1.859 μM (Jak2), 5.807 μM (Jak3), 0.412 μM (RET), 0.687 μM (KOR), 1.783 μM (FLT3), 16.96 μM (FGFR1), 5.662 μM (FGFR3), and 0.709 μM (Pyk2), respectively .

HY-174369

TREM2 agonist-3	TREM receptor Syk	Neurological Disease
TREM2 agonist-3 (Compound 4i) is a TREM2 agonist with a K_D value of 19.0 µM. The K_D value of TREM2 agonist-3 for TREM1 is 39.8 µM. TREM2 agonist-3 induces an increase in phosphorylated SYK levels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases and other diseases associated with TREM2 dysfunction .

HY-12736A

GSK143 dihydrochloride 1 Publications Verification	Syk ERK	Inflammation/Immunology Cancer
GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.5. GSK143 dihydrochloride inhibits phosphorylated Erk (pErk: pIC₅₀=7.1) . GSK143 dihydrochloride reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice .

HY-112319

(R,S)-MK-8457	Drug Isomer Syk	Cardiovascular Disease Inflammation/Immunology
(R,S)-MK-8457 is a stereoisomer of MK-8457. MK-8457 is a dual inhibitor of Syk and ZAP70 .

HY-109082A

Cevidoplenib dimesylate SKI-O-703 dimesylate	Syk	Inflammation/Immunology
Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities .

HY-100867

Mivavotinib TAK-659; CB-659	Syk FLT3	Cancer
TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and *fms related tyrosine* kinase 3 (FLT3), with an IC₅₀** of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL) .

HY-112809

GSK2646264	Syk Src LRRK2 GSK-3 JAK VEGFR Aurora Kinase	Inflammation/Immunology
GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.1. GSK2646264 also inhibits other kinases with pIC₅₀ values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin .

HY-124146

BI1002494	Syk	Inflammation/Immunology
BI1002494 is an orally active, potent, and selective spleen tyrosine kinase (SYK) inhibitor. BI 1002494 exhibits an IC₅₀ of 115 nM in inhibiting high-affinity IgE receptor-mediated mast cell and basophil degranulation. BI1002494 can be utilized in immunology reesearch .

HY-12736

GSK143	Syk ERK	Inflammation/Immunology Cancer
GSK143 is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.5. GSK143 inhibits phosphorylated Erk (pErk: pIC₅₀=7.1) . GSK143 reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice .

HY-162427

NMS-0963	Syk	Endocrinology
NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC₅₀ value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM .

HY-149895

Syk-IN-7	Syk	Cancer
Syk-IN-7 (compound 17) is an inhibitor of spleen tyrosine kinase (SYK) .

HY-169630

DBMB	NF-κB Prostaglandin Receptor NO Synthase Syk	Inflammation/Immunology
DBMB is an inhibitor of spleen tyrosine kinase (Syk), capable of significantly inhibiting the activity of Syk kinase. DBMB exhibits anti-inflammatory activity by suppressing the signaling of NF-κB, which in turn reduces the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases .

HY-100867AR

Mivavotinib monohydrochloride (Standard) TAK-659 monohydrochloride (Standard); CB-659 monohydrochloride (Standard)	Syk Reference Standards FLT3	Cancer
Mivavotinib (monohydrochloride) (Standard) is the analytical standard of Mivavotinib (monohydrochloride) (HY-100867A). This product is intended for research and analytical applications. TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL) .

HY-112319A

MK-8457	Syk	Cardiovascular Disease Inflammation/Immunology
MK-8457 is a dual inhibitor of spleen tyrosine kinase (SYK) and zeta-chain-associated protein kinase 70 (ZAP70). MK-8457 can be used for the researches of rheumatoid arthritis, hypertension .

HY-125585

Syk-IN-2	Syk	Others
Syk-IN-2 (Page 78; 35) is a spleen tyrosine kinase (Syk) inhibitor .

HY-156196

BI 894416	Syk	Inflammation/Immunology
BI 894416 is a spleen tyrosine kinase (SYK) inhibitor. BI 894416 has a deuterium-labeled derivative that can be used as an internal standard for bioanalytical studies. BI 894416 is applicable to the research of severe asthma .

HY-18911

Type-II-IN-1	Syk	Inflammation/Immunology
Type-II-IN-1 (Compound 3) is a type II spleen tyrosine kinase (Syk) inhibitor with an IC₅₀ of 2.1 nM. Type-II-IN-1 can bind to the DFG-out conformation of Syk. Type-II-IN-1 can be used for the research of immunology, such as asthma .

Species:	Human (3)
Tag:	His (1) Tag Free (1) Avi (1)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701637

	SYK Protein, Human (sf9, His) SYK; tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk	Human	Sf9 insect cells
	SYK protein is a non-receptor tyrosine kinase that mediates signal transduction across different receptors, including B-cell receptors (BCR), affecting innate and adaptive immunity, cell adhesion, and osteoclast maturation , platelet activation and vascular development. SYK forms complexes with activated receptors, phosphorylates downstream effectors, and is critical in BCR and T cell receptor signaling. SYK Protein, Human (sf9, His) is the recombinant human-derived SYK protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P701638

	SYK Protein, Human (Active, sf9) SYK; tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk	Human	Sf9 insect cells
	SYK protein is a non-receptor tyrosine kinase that mediates signal transduction across different receptors, including B-cell receptors (BCR), affecting innate and adaptive immunity, cell adhesion, and osteoclast maturation , platelet activation and vascular development. SYK forms complexes with activated receptors, phosphorylates downstream effectors, and is critical in BCR and T cell receptor signaling. SYK Protein, Human (sf9) is the recombinant human-derived SYK protein, expressed by sf9 insect cells , with tag free.

HY-P702728

	SYK Protein, Human (Active, Biotinylated, sf9, Avi) SYK; Spleen tyrosine kinase; tyrosine-protein kinase SYK; p72-Syk; FLJ25043; FLJ37489; DKFZp313N1010	Human	Sf9 insect cells
	SYK protein is a non-receptor tyrosine kinase that mediates signal transduction across different receptors, including B-cell receptors (BCR), affecting innate and adaptive immunity, cell adhesion, and osteoclast maturation, platelet activation and vascular development. SYK forms complexes with activated receptors, phosphorylates downstream effectors, and is critical in BCR and T cell receptor signaling. SYK Protein, Human (Biotinylated, sf9, Avi) is the recombinant human-derived SYK, expressed by Sf9 insect cells, with N-Avi labeled tag.

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Host:	Rabbit (3)
Reactivity:	Human (3) Rat (2) Mouse (3)
Application:	IHC-P (1) ICC/IF (3) IP (2) WB (3) ELISA (3)
Isotype:	IgG/Kappa (2) IgG,IgG/Kappa (1)
Conjugation:	Non-conjugated (3) Biotin (1)
Clonality:	Monoclonal (3)
Modification:	Phosphorylated (2) Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86408

	SYK Antibody (YA6100) SYK; tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	SYK Antibody (YA6100) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SYK.

HY-P86108

	Phospho-SYK(Tyr525/526)Antibody(YA5800) SYK; tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-SYK(Tyr525/526)Antibody(YA5800) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-SYK(Tyr525/526).

HY-P86168

	Phospho-Zap70(Tyr319)/Syk(Tyr352)Antibody (YA5860) ZAP70; SRK; tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase; SYK; tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk;	WB, ICC/IF, ELISA	Human, Mouse
	Phospho-Zap70(Tyr319)/Syk(Tyr352)Antibody (YA5860) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Zap70(Tyr319)/Syk(Tyr352).

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