2. Others Protein Tyrosine Kinase/RTK
  3. Reference Standards Syk FLT3
  4. Mivavotinib monohydrochloride (Standard)

Mivavotinib monohydrochloride (Standard)  (Synonyms: TAK-659 monohydrochloride (Standard); CB-659 monohydrochloride (Standard))

Cat. No.: HY-100867AR Purity: 98%
Handling Instructions Technical Support

Mivavotinib (monohydrochloride) (Standard) is the analytical standard of Mivavotinib (monohydrochloride) (HY-100867A). This product is intended for research and analytical applications. TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL).

For research use only. We do not sell to patients.

Mivavotinib monohydrochloride (Standard)

Mivavotinib monohydrochloride (Standard) Chemical Structure

CAS No. : 1952251-28-3

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10 mg Get quote 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
25 mg Get quote 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
50 mg Get quote 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
100 mg Get quote 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
200 mg   Get quote  
500 mg   Get quote  
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Information

Mivavotinib (monohydrochloride) (Standard) is the analytical standard of Mivavotinib (monohydrochloride) (HY-100867A). This product is intended for research and analytical applications. TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL).

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

380.85

Formula

C17H22ClFN6O
CAS No.
SMILES

FC1=C(N[C@@H]2CCCC[C@@H]2N)N=C(C3=CN(C)N=C3)C4=C1CNC4=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Mivavotinib monohydrochloride (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mivavotinib monohydrochloride (Standard)1952251-28-3TAK-659 monohydrochloride (Standard) CB-659 monohydrochloride (Standard)Reference StandardsSykFLT3Spleen tyrosine kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3SpleentyrosinekinaseSYKfmsrelatedCLLInhibitorinhibitorinhibit

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