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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
TGF-β inhibition
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "TGF-β inhibition" in MCE Product Catalog:
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22 Publications Verification
Cat. No.: HY-N1584A
CAS No.: 64924-67-0
Synonyms: RU-19110 hydrobromide
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Research Areas:
Cardiovascular Disease Infection Inflammation/Immunology Cancer
Halofuginone lactate (RU-19110 lactate), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca 2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .
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Halofuginone hydrochloride (RU-19110 hydrochloride), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone hydrochloride is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrochloride is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca 2+ channels. Halofuginone hydrochloride has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .
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18 Cited Publications
Cat. No.: HY-P0299
CAS No.: 283609-79-0
Target:
Research Areas:
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18 Cited Publications
Cat. No.: HY-P0299A
CAS No.: 2828433-17-4
Target:
Research Areas:
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Category:
Alkaloids Other Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Synonyms: GED-0301 sodium
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Research Areas:
Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice .
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Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice .
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THRX-144644 is a Lung-restricted ALK5 inhibitor with an IC50 value of 0.14 nM. THRX-144644 avoids systemic toxicities associated with TGFβ pathway inhibition .
Cat. No.: HY-16363
CAS No.: 195883-06-8
Synonyms: PG 490-88
Research Areas:
Omtriptolide (PG490-88) is a derivative proagent of triptolide purified from the Chinese herb.
Cat. No.: HY-P10414A
Synonyms: KP1 (human) hydrochloride
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Research Areas:
Cat. No.: HY-N1584R
CAS No.: 55837-20-2
Synonyms: RU-19110 (Standard)
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DT-6 is an effective TGF-β1 inhibitor. DT-6 inhibits M2 macrophage induced epithelial to mesenchymal transition and invasive migration of cancer cells. DT-6 can be used for cancer diseases research .
Cat. No.: HY-N1584AR
CAS No.: 64924-67-0
Synonyms: RU-19110 hydrobromide (Standard)
Cat. No.: HY-P10414
Synonyms: KP1 (human)
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Research Areas:
Cat. No.: HY-W105272R
CAS No.: 2922-74-9
Category:
Cat. No.: HY-N1584BR
CAS No.: 1217623-74-9
Synonyms: RU-19110 hydrochloride (Standard)
Halofuginone hydrochloride (Standard) (RU-19110 hydrochloride (Standard)) is the analytical standard of Halofuginone hydrochloride (HY-N1584B). This product is intended for research and analytical applications. Halofuginone hydrochloride (RU-19110 hydrochloride), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone hydrochloride is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrochloride is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca 2+ channels. Halofuginone hydrochloride has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .
Cat. No.: HY-170227
Research Areas:
Autotaxin-IN-7 (45), a pyridine-2-carboxylic derivative, demonstrates subnanomolar ATX inhibition (IC50 = 0.086 nM), with a favorable heart safety profile (hERG > 30 μM) and minimal fibroblast toxicity. Autotaxin-IN-7 (45) suppresses the TGF-β/Smad signaling pathway, downregulating α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) is used in the research for pulmonary fibrosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
