2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Anti-infection Membrane Transporter/Ion Channel Neuronal Signaling
  3. DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
  4. Halofuginone lactate

Halofuginone lactate  (Synonyms: RU-19110 lactate)

Cat. No.: HY-N1584C Purity: 98.32%
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Halofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

For research use only. We do not sell to patients.

CAS No. : 82186-71-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 20 publication(s) in Google Scholar

Other Forms of Halofuginone lactate:

Halofuginone lactate Related Antibodies

Top Publications Citing Use of Products

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2514837122.  [Abstract]

    Cultured L929, L929(Pkr-/-Hri-/-Perk-/-Gcn2-/-), L929(G3bp1-/-G3bp2-/-), L929(Zbp1-/-), L929(Ripk3-/-) and L929(Mlkl-/-) cells were treated Halofuginone (500 nM) and Halofuginone (500 nM)+IFN-β(10 ng/ml) for 42 hours; The intracellular ATP levels were measured by Cell Titer-Glo.

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jul 25:143:156788.

    Cell morphology under the microscope after 24 h of 4 μM AUM in combination with 50 nM Halofuginone (HF) in the resistant cell lines and inhibition of colony formation.

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2024 Jul.

    Cell viability measured by MTT assay after treatment with 100, 200, 400, 800, and 1000 nM concentrations of Halofuginone (HF) in parental cells MDA-MB-231 and BT-20 for 24 h, as well as resistant cells MDA-MB-231/PR and BT-20/PR.

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2024 Jul.

    Halofuginone (HF; 200 nM; 24 h) treated MDA-MB-231/PR and BT20/PR cells reduced cell invasion capabilities.

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Sep;178(17):3373-3394.  [Abstract]

    Western blot analysis on p-Akt, Akt, p-mTOR and mTOR in control PASMCs and PASMCs treated with PDGF in the absence (vehicle control, Veh) and presence (Halofuginone; HF) of 1 μM halofuginone (for 24 h).

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    Description

    Halofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].

    Molecular Weight

    504.76

    Formula

    C19H23BrClN3O6
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC(C(O)C)=O.O=C1C2=CC(Cl)=C(Br)C=C2N=CN1CC(C[C@H]3[C@@H](CCCN3)O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 35 mg/mL (69.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9811 mL 9.9057 mL 19.8114 mL
    5 mM 0.3962 mL 1.9811 mL 3.9623 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9811 mL 9.9057 mL 19.8114 mL 49.5285 mL
    5 mM 0.3962 mL 1.9811 mL 3.9623 mL 9.9057 mL
    10 mM 0.1981 mL 0.9906 mL 1.9811 mL 4.9528 mL
    15 mM 0.1321 mL 0.6604 mL 1.3208 mL 3.3019 mL
    20 mM 0.0991 mL 0.4953 mL 0.9906 mL 2.4764 mL
    25 mM 0.0792 mL 0.3962 mL 0.7925 mL 1.9811 mL
    30 mM 0.0660 mL 0.3302 mL 0.6604 mL 1.6509 mL
    40 mM 0.0495 mL 0.2476 mL 0.4953 mL 1.2382 mL
    50 mM 0.0396 mL 0.1981 mL 0.3962 mL 0.9906 mL
    60 mM 0.0330 mL 0.1651 mL 0.3302 mL 0.8255 mL
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    Halofuginone lactate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Halofuginone82186-71-8RU-19110RU19110RU 19110DNA/RNA SynthesisTGF-beta/SmadParasiteSodium ChannelCalcium ChannelTransforming growth factor betaNa channelsNa+ channelsCa2+ channelsCa channelstype-Icollagencollagen-1prolyl-tRNAosteoarthritisTGF-βInhibitorinhibitorinhibit

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