Copy Link Print Information

Halofuginone lactate

(Synonyms: RU-19110 lactate)
22 Cited Publications
Customer Review

Based on 22 publication(s) in Google Scholar

Halofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

For research use only. We do not sell to patients.

  • Purity: 98.32%
  • CAS No.: 82186-71-8
  • Formula: C19H23BrClN3O6
  • Molecular Weight:504.76
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Halofuginone lactate Chemical Structure
    Halofuginone lactate Chemical Structure
  • Experimental Validation Results for Halofuginone lactate
  • Experimental Validation Results for Halofuginone lactate
  • Experimental Validation Results for Halofuginone lactate
  • Experimental Validation Results for Halofuginone lactate
  • Experimental Validation Results for Halofuginone lactate
CAS No.: 82186-71-8
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Halofuginone lactate:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Solvent & Solubility
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Halofuginone lactate

More
Customer Validation & Images
Bio/Physico-chemical AssayCell Imaging/StainingWBCell Proliferation/Viability AssayCell Migration/Invasion Assay
  • Cell Imaging/Staining
  • Bio/Physico-chemical Assay
  • Cell Proliferation/Viability Assay
  • Cell Migration/Invasion Assay
  • WB

All DNA/RNA Synthesis Isoforms

More

All TGF-beta/Smad Isoforms

More

All Parasite Isoforms

More

All Sodium Channel Isoforms

More

All Calcium Channel Isoforms

More
Keywords
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Halofuginone lactate Chemical Structure
    Halofuginone lactate Chemical Structure
    1/16
  • 1/16

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jul 25:143:156788. [Abstract]

    Customer Validation
     Cell morphology under the microscope after 24 h of 4 μM AUM in combination with 50 nM Halofuginone (HF) in the resistant cell lines and inhibition of colony formation.

  • 1/16

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2514837122. [Abstract]

    Customer Validation
     Cultured L929, L929(Pkr-/-Hri-/-Perk-/-Gcn2-/-), L929(G3bp1-/-G3bp2-/-), L929(Zbp1-/-), L929(Ripk3-/-) and L929(Mlkl-/-) cells were treated Halofuginone (500 nM) and Halofuginone (500 nM)+IFN-β(10 ng/ml) for 42 hours; The intracellular ATP levels were measured by Cell Titer-Glo.

  • 1/16

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2024 Jul.

    Customer Validation
     Cell viability measured by MTT assay after treatment with 100, 200, 400, 800, and 1000 nM concentrations of Halofuginone (HF) in parental cells MDA-MB-231 and BT-20 for 24 h, as well as resistant cells MDA-MB-231/PR and BT-20/PR.

  • 1/16

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2024 Jul.

    Customer Validation
     Halofuginone (HF; 200 nM; 24 h) treated MDA-MB-231/PR and BT20/PR cells reduced cell invasion capabilities.

  • 1/16

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Sep;178(17):3373-3394. [Abstract]

    Customer Validation
     Western blot analysis on p-Akt, Akt, p-mTOR and mTOR in control PASMCs and PASMCs treated with PDGF in the absence (vehicle control, Veh) and presence (Halofuginone; HF) of 1 μM halofuginone (for 24 h).

  • Halofuginone lactate