1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK

Omtriptolide 

Cat. No.: HY-16363 Purity: 98.29%
Data Sheet SDS Handling Instructions

Omtriptolide (PG490-88) is a water soluble derivative prodrug of triptolide purified from the Chinese herb.

For research use only. We do not sell to patients.
Omtriptolide Chemical Structure

Omtriptolide Chemical Structure

CAS No. : 195883-06-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $456 In-stock
1 mg $150 In-stock
5 mg $450 In-stock
10 mg $650 In-stock
25 mg $1300 In-stock
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Omtriptolide (PG490-88) is a water soluble derivative prodrug of triptolide purified from the Chinese herb.

In Vitro

Triptolide, a traditional Chinese medicine, has anti-inflammatory, antiproliferative, and proapoptotic properties[1].

In Vivo

In a mouse model of cisplatin-induced AKI, omtriptolide results in a significant decrease in blood urea nitrogen (BUN), serum creatinine, and acute tubular necrosis (ATN) score, and a nonsignificant increase in tubular apoptosis score in AKI. The protection of omtriptolide against AKI is associated with a decrease in p-ERK and is independent of MKP-1 and proinflammatory cytokines[1]. In a mouse heterotopic tracheal allograft model of obliterative airway disease, omtriptolide attenuates airway obliteration and inhibits accumulation of inflammatory cells, and therefore may have preventive or therapeutic benefits for patients with obliterative airway disease following lung transplantation[2]. Omtriptolide inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. Omtriptolide also markedly reduces the number of myofibroblasts in the bleomycin treatment group[3]. Omtriptolide inhibits in vivo both CD4+Vbeta3+ and CD8+Vbeta3+ T cell (alloreactive T cells in this model) expansion in the spleen by 64.09 and 34.02%, respectively, at the time when Vbeta3+ cell expansion is in the logarithmic phase (day 3 after transplantation)[4].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1717 mL 10.8585 mL 21.7169 mL
5 mM 0.4343 mL 2.1717 mL 4.3434 mL
10 mM 0.2172 mL 1.0858 mL 2.1717 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[2]

Omtriptolide is prepared in sterile water.

Mouse: Omtriptolide (0.25 mg/kg per day) is started immediately after the transplant and 10 control mice receive intraperitoneal injections of sterile water each day. The mice are then maintained for 28 days until killing, at which time the mice are administered CO2 inhalation, and cervical dislocation is performed. Trachea is divided for histologic staining and immunohistochemistry [2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

460.47

Formula

C₂₄H₂₈O₉

CAS No.

195883-06-8

Storage

4°C, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 10 mM

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Omtriptolide
Cat. No.:
HY-16363
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