1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK
  3. Omtriptolide

Omtriptolide 

Cat. No.: HY-16363 Purity: 98.29%
Handling Instructions

Omtriptolide (PG490-88) is a water soluble derivative prodrug of triptolide purified from the Chinese herb.

For research use only. We do not sell to patients.

Omtriptolide Chemical Structure

Omtriptolide Chemical Structure

CAS No. : 195883-06-8

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10 mM * 1 mL in DMSO USD 547 In-stock
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Description

Omtriptolide (PG490-88) is a water soluble derivative prodrug of triptolide purified from the Chinese herb.

IC50 & Target[1]

ERK

 

In Vitro

Triptolide, a traditional Chinese medicine, has anti-inflammatory, antiproliferative, and proapoptotic properties[1].

In Vivo

In a mouse model of cisplatin-induced AKI, omtriptolide results in a significant decrease in blood urea nitrogen (BUN), serum creatinine, and acute tubular necrosis (ATN) score, and a nonsignificant increase in tubular apoptosis score in AKI. The protection of omtriptolide against AKI is associated with a decrease in p-ERK and is independent of MKP-1 and proinflammatory cytokines[1]. In a mouse heterotopic tracheal allograft model of obliterative airway disease, omtriptolide attenuates airway obliteration and inhibits accumulation of inflammatory cells, and therefore may have preventive or therapeutic benefits for patients with obliterative airway disease following lung transplantation[2]. Omtriptolide inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. Omtriptolide also markedly reduces the number of myofibroblasts in the bleomycin treatment group[3]. Omtriptolide inhibits in vivo both CD4+Vbeta3+ and CD8+Vbeta3+ T cell (alloreactive T cells in this model) expansion in the spleen by 64.09 and 34.02%, respectively, at the time when Vbeta3+ cell expansion is in the logarithmic phase (day 3 after transplantation)[4].

Molecular Weight

460.47

Formula

C₂₄H₂₈O₉

CAS No.

195883-06-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
Animal Administration
[2]

Mice: Omtriptolide (0.25 mg/kg per day) is started immediately after the transplant and 10 control mice receive intraperitoneal injections of sterile water each day. The mice are then maintained for 28 days until killing, at which time the mice are administered CO2 inhalation, and cervical dislocation is performed. Trachea is divided for histologic staining and immunohistochemistry [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Omtriptolide
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