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UV irradiation

" in MedChemExpress (MCE) Product Catalog:

28

Inhibitors & Agonists

12

Biochemical Assay Reagents

1

Peptides

1

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-122198
    ML367
    1 Publications Verification

    		 Checkpoint Kinase (Chk) Cancer
    ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation .
    ML367
  • HY-164159
    α-Glucosylrutin

    		Reactive Oxygen Species (ROS) MMP Inflammation/Immunology
    α-Glucosylrutin, a flavonoid, is a potent antioxidant with free radical scavenging activity. α-Glucosylrutin reduces MMP-1 gene expression, protein expression, and enzyme activity, and reduces MMP-2 protein expression and enzyme activity in UVA-irradiated human dermal fibroblasts. α-Glucosylrutin prevents oxidative stress-induced intracellular tyrosine residue phosphorylation and counteracts intracellular thiol level depletion in human skin cells. α-Glucosylrutin is effective in the prevention of dermatologic diseases in which oxidative stress is of pathogenetic relevance, e.g. in polymorphous light eruption (PLE). α-Glucosylrutin can be used for the research of UV-induced skin photodamage/photoaging .
    α-Glucosylrutin
  • HY-109654
    Ensulizole

    		Reactive Oxygen Species (ROS) Metabolic Disease
    Ensulizole is a sulfonated UV absorber and can intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation .
    Ensulizole
  • HY-W011168
    8-Bromo-2'-deoxyguanosine

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Inflammation/Immunology Cancer
    8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H2O2-Cl --Br - system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation .
    8-Bromo-2'-deoxyguanosine
  • HY-W583212
    Zn(II) Mesoporphyrin IX

    ZnMP

    		 Biochemical Assay Reagents Heme Oxygenase (HO) Inflammation/Immunology
    Zn (II) Mesoporphyrin IX (ZnMP) is a heme oxygenase inhibitor with photochemical substrate activity. Zn (II) Mesoporphyrin IX specifically inhibits the activity of bone marrow heme oxygenase. In vitro, Zn (II) Mesoporphyrin IX inhibits the growth of erythroid and myeloid progenitor cells in rabbit bone marrow, and blocks the rhG-CSF-induced mobilization of these progenitor cells into the peripheral blood, exhibiting toxicity to hematopoietic growth and progenitor cell production in rabbits. Zn (II) Mesoporphyrin IX undergoes irreversible photochemical decomposition conforming to first-order kinetic characteristics when irradiated with UV-B in 95% ethanol solution. Zn (II) Mesoporphyrin IX can be used in hematopoietic regulation research, but its photolability and toxic effects on the hematopoietic system require attention .
    Zn(II) Mesoporphyrin IX
  • HY-W098021
    2,2-Dimethoxy-2-phenylacetophenone

    Photoinitiator-651

    		 Biochemical Assay Reagents Others
    2,2-Dimethoxy-2-phenylacetophenone is a hydrophobic benzoin ether-based free radical photoinitiator. 2,2-Dimethoxy-2-phenylacetophenone undergoes α-cleavage upon UV irradiation to generate benzoyl and substituted benzyl free radicals, thereby initiating photopolymerization reactions. 2,2-Dimethoxy-2-phenylacetophenone serves as a hydrophobic free radical photoinitiator for the photopolymerization of acrylamide and trimethylolpropane triacrylate in specific systems .
    2,2-Dimethoxy-2-phenylacetophenone
  • HY-158220
    Hyaluronic acid Methacryloyl (MW 400 kDa)

    HAMA (MW 400 kDa)

    		 Biochemical Assay Reagents Others
    Hyaluronic acid Methacryloyl (HAMA) is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .
    Hyaluronic acid Methacryloyl (MW 400 kDa)
  • HY-158220A
    Hyaluronic acid Methacryloyl (MW 150 kDa)

    HAMA (MW 150 kDa)

    		 Biochemical Assay Reagents Others
    Hyaluronic acid Methacryloyl (HAMA) MW 150 kDa is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .
    Hyaluronic acid Methacryloyl (MW 150 kDa)
  • HY-P4417A
    Ac-IEPD-AMC TFA

    		Fluorescent Dye Others
    Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
    Ac-IEPD-AMC TFA
  • HY-W110540D
    Poly(ethylene glycol) dimethacrylate (MW 2000)

    		Biochemical Assay Reagents Others
    Poly(ethylene glycol) dimethacrylate (MW 2000) is a photopolymerizable poly(ethylene glycol)-based macromer and biocompatible crosslinking agent with a molecular weight of approximately 2000. Poly(ethylene glycol) dimethacrylate (MW 2000) can form photopolymerized hydrogels. Poly(ethylene glycol) dimethacrylate (MW 2000) can be used for research on tissue engineering and drug delivery .
    Poly(ethylene glycol) dimethacrylate (MW 2000)
  • HY-171145
    ATP-ArN3

    		Biochemical Assay Reagents Others
    ATP-ArN3 is a UV-activatable ATP-crosslinker analog. ATP-ArN3 relys on UV irradiation to activate the aryl azide (ArN3) crosslinking group and conjugate substrate to kinases and associated proteins .
    ATP-ArN3
  • HY-W110540H
    Poly(ethylene glycol) dimethacrylate (MW 3400)

    		Biochemical Assay Reagents Others
    Poly(ethylene glycol) dimethacrylate (MW 3400) is a photopolymerizable poly(ethylene glycol)-based macromer and biocompatible crosslinking agent with a molecular weight of approximately 3400. Poly(ethylene glycol) dimethacrylate (MW 3400) can form photopolymerized hydrogels. Poly(ethylene glycol) dimethacrylate (MW 3400) can be used for research on tissue engineering and drug delivery .
    Poly(ethylene glycol) dimethacrylate (MW 3400)
  • HY-W110540K
    Poly(ethylene glycol) dimethacrylate (MW 10000)

    		Biochemical Assay Reagents Others
    Poly(ethylene glycol) dimethacrylate (MW 10000) is a photopolymerizable poly(ethylene glycol)-based macromer and biocompatible crosslinking agent with a molecular weight of approximately 10000. Poly(ethylene glycol) dimethacrylate (MW 10000) can form photopolymerized hydrogels. Poly(ethylene glycol) dimethacrylate (MW 10000) can be used for research on tissue engineering and drug delivery .
    Poly(ethylene glycol) dimethacrylate (MW 10000)
  • HY-W110540L
    Poly(ethylene glycol) dimethacrylate (MW 20000)

    		Biochemical Assay Reagents Others
    Poly(ethylene glycol) dimethacrylate (MW 20000) is a photopolymerizable poly(ethylene glycol)-based macromer and biocompatible crosslinking agent with a molecular weight of approximately 20000. Poly(ethylene glycol) dimethacrylate (MW 20000) can form photopolymerized hydrogels. Poly(ethylene glycol) dimethacrylate (MW 20000) can be used for research on tissue engineering and drug delivery .
    Poly(ethylene glycol) dimethacrylate (MW 20000)
  • HY-W110540C
    Poly(ethylene glycol) dimethacrylate (MW 1000)

    		Biochemical Assay Reagents Others
    Poly(ethylene glycol) dimethacrylate (MW 1000) is a photopolymerizable poly(ethylene glycol)-based macromer and biocompatible crosslinking agent with a molecular weight of approximately 1000. Poly(ethylene glycol) dimethacrylate (MW 1000) can form photopolymerized hydrogels. Poly(ethylene glycol) dimethacrylate (MW 1000) can be used for research on tissue engineering and drug delivery .
    Poly(ethylene glycol) dimethacrylate (MW 1000)
  • HY-W110540A
    Poly(ethylene glycol) dimethacrylate (MW 750)

    		Biochemical Assay Reagents Others
    Poly(ethylene glycol) dimethacrylate (MW 750) is a photopolymerizable poly(ethylene glycol)-based macromer and biocompatible crosslinking agent with a molecular weight of approximately 750. Poly(ethylene glycol) dimethacrylate (MW 750) can form photopolymerized hydrogels. Poly(ethylene glycol) dimethacrylate (MW 750) can be used for research on tissue engineering and drug delivery .
    Poly(ethylene glycol) dimethacrylate (MW 750)
  • HY-W110540
    Poly(ethylene glycol) dimethacrylate (MW 550)

    		Biochemical Assay Reagents Others
    Poly(ethylene glycol) dimethacrylate (MW 550) is a photopolymerizable poly(ethylene glycol)-based macromer and biocompatible crosslinking agent with a molecular weight of approximately 550. Poly(ethylene glycol) dimethacrylate (MW 550) can form photopolymerized hydrogels. Poly(ethylene glycol) dimethacrylate (MW 550) can be used for research on tissue engineering and drug delivery .
    Poly(ethylene glycol) dimethacrylate (MW 550)
  • HY-W110540I
    Poly(ethylene glycol) dimethacrylate (MW 4000)

    		Biochemical Assay Reagents Others
    Poly(ethylene glycol) dimethacrylate (MW 4000) is a photopolymerizable poly(ethylene glycol)-based macromer and biocompatible crosslinking agent with a molecular weight of approximately 4000. Poly(ethylene glycol) dimethacrylate (MW 4000) can form photopolymerized hydrogels. Poly(ethylene glycol) dimethacrylate (MW 4000) can be used for research on tissue engineering and drug delivery .
    Poly(ethylene glycol) dimethacrylate (MW 4000)
  • HY-W110540J
    Poly(ethylene glycol) dimethacrylate (MW 6000)

    		Biochemical Assay Reagents Others
    Poly(ethylene glycol) dimethacrylate (MW 6000) is a photopolymerizable poly(ethylene glycol)-based macromer and biocompatible crosslinking agent with a molecular weight of approximately 6000. Poly(ethylene glycol) dimethacrylate (MW 6000) can form photopolymerized hydrogels. Poly(ethylene glycol) dimethacrylate (MW 6000) can be used for research on tissue engineering and drug delivery .
    Poly(ethylene glycol) dimethacrylate (MW 6000)
  • HY-109654R
    Ensulizole (Standard)

    		Reference Standards Reactive Oxygen Species (ROS) Metabolic Disease
    Ensulizole (Standard) is the analytical standard of Ensulizole. This product is intended for research and analytical applications. Ensulizole is a sulfonated UV absorber and can intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation .
    Ensulizole (Standard)
  • HY-161160
    Ac4ManNDAz

    		Fluorescent Dye Others
    Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins .
    Ac4ManNDAz
  • HY-155730
    PI3K-IN-41

    		PI3K Cancer
    PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect .
    PI3K-IN-41
  • HY-W767399
    8-Bromo-2'-deoxyguanosine-13C,15N2

    		Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Cancer
    8-Bromo-2'-deoxyguanosine- 13C, 15N2 is the 13C- and 15N-labeled 8-Bromo-2'-deoxyguanosine (HY-W011168). 8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H2O2-Cl --Br - system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation .
    8-Bromo-2'-deoxyguanosine-13C,15N2
  • HY-106849
    Y-26611

    		Drug Derivative Inflammation/Immunology
    Y-26611 is an orally active new type of quinolone derivative. Y-26611 exhibits strong phototoxicity under UV irradiation and can significantly induce lipid peroxidation of human red blood cell membrane .
    Y-26611
  • HY-183342
    DHEA Benzophenone-biotin

    		NO Synthase Drug Derivative Metabolic Disease
    DHEA Benzophenone-biotin is a photoactive DHEA (HY-14650) analog containing Biotin (HY-B0511) and Benzophenone (HY-Y0546) groups. DHEA Benzophenone-biotin inhibits plasma membrane binding of DHEA, activates endothelial NO synthase. DHEA Benzophenone-biotin cross-links to plasma membrane DHEA binding sites upon UV irradiation to identify associated proteins .
    DHEA Benzophenone-biotin
  • HY-180983
    Azo-PROTAC-4C-trans

    		PROTACs Bcr-Abl Cancer
    Azo-PROTAC-4C-trans is a BCR-ABL PROTAC degrader that can efficiently degrade the BCR-ABL fusion protein and ABL protein. Azo-PROTAC-4C-trans exhibits potent selective anti-proliferative activity against K562 cells. Azo-PROTAC-4C-trans allows real-time, reversible regulation of its activity via UV (to inactivate it) /visible light (to activate it) irradiation. Azo-PROTAC-4C-trans can be used for the study of myeloid leukemia .
    Azo-PROTAC-4C-trans
  • HY-118720A
    Ovothiol A TFA

    U-23 TFA

    		 Reactive Oxygen Species (ROS) Others
    Ovothiol A TFA (U-23 TFA) is an antioxidant. Ovothiol A TFA can be isolated from the tissues of marine invertebrates, algae and fish. Ovothiol A acts synergistically with glutathione to actively scavenge ROS and free radicals, and quench the triplet state of Kynurenic acid (HY-100806), thereby inhibiting oxidative stress and photodamage. OSH is expected to serve as an excellent photoprotective agent to inhibit the harmful effects caused by solar ultraviolet radiation .
    Ovothiol A TFA
  • HY-180985
    Azo-PROTAC-4C-cis

    		PROTACs Bcr-Abl Cancer
    Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia .
    Azo-PROTAC-4C-cis

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