2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3K-IN-41

PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect.

For research use only. We do not sell to patients.

PI3K-IN-41 Chemical Structure

PI3K-IN-41 Chemical Structure

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PI3K-IN-41 Related Antibodies

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Description

PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect[1].

IC50 & Target

IC50:18.92 nM (PI3K)[1]
In Vitro

PI3K-IN-41 (copound 2) (10 nM) decreases AKT phosphorylation in HGC-27 cells, and (1-10 μM) inhibits colony formation of HGC-27 cells, after exposure to UV light irradiation for 5 min, 15 min, and 30 min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K-IN-41 Related Antibodies
Molecular Weight

911.88

Formula

C45H39F2N5O12S
SMILES

COC1=CC(COC2=CC3=C(C=C(C(O3)=O)CN(S(C4=C(C=C(C=C4)F)F)(=O)=O)C5=C(N=CC(C6=CC7=C(N=CN=C7C(OC8CCOCC8)=C6)C)=C5)OC)C=C2)=C(C=C1OC)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3K-IN-41 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-41PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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PI3K-IN-41
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HY-155730
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