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Cat. No.: HY-155730

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PI3K-IN-41

PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC₅₀=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect.

For research use only. We do not sell to patients.

Formula: C₄₅H₃₉F₂N₅O₁₂S
Molecular Weight:911.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

PI3K-IN-41 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50:18.92 nM (PI3K)^[1]

All PI3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HGC-27	IC₅₀	3.7 nM Compound: 2	Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay	[PMID: 37583818]
HGC-27	IC₅₀	701 nM Compound: 2	Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay	[PMID: 37583818]
MCF7	IC₅₀	428 nM Compound: 2	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay	[PMID: 37583818]
MCF7	IC₅₀	>10000 nM Compound: 2	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay	[PMID: 37583818]
SK-MEL-2	IC₅₀	143 nM Compound: 2	Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay	[PMID: 37583818]
SK-MEL-2	IC₅₀	2812 nM Compound: 2	Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay	[PMID: 37583818]
SK-MEL-5	IC₅₀	434 nM Compound: 2	Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay	[PMID: 37583818]
SK-MEL-5	IC₅₀	6556 nM Compound: 2	Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay	[PMID: 37583818]
U-87MG ATCC	IC₅₀	3257 nM Compound: 2	Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay	[PMID: 37583818]
U-87MG ATCC	IC₅₀	52 nM Compound: 2	Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay	[PMID: 37583818]

In Vitro

PI3K-IN-41 (copound 2) (10 nM) decreases AKT phosphorylation in HGC-27 cells, and (1-10 μM) inhibits colony formation of HGC-27 cells, after exposure to UV light irradiation for 5 min, 15 min, and 30 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 911.88
Formula C₄₅H₃₉F₂N₅O₁₂S
SMILES

COC1=CC(COC2=CC3=C(C=C(C(O3)=O)CN(S(C4=C(C=C(C=C4)F)F)(=O)=O)C5=C(N=CC(C6=CC7=C(N=CN=C7C(OC8CCOCC8)=C6)C)=C5)OC)C=C2)=C(C=C1OC)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tian H, et al. Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release. ACS Med Chem Lett. 2023 Jul 24;14(8):1100-1107. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PI3K-IN-41

All PI3K Isoforms