2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3K-IN-41

PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect.

For research use only. We do not sell to patients.

PI3K-IN-41

PI3K-IN-41 Chemical Structure

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PI3K-IN-41 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect[1].

IC50 & Target

IC50:18.92 nM (PI3K)[1]
Cellular Effect
Cell Line Type Value Description References
HGC-27 IC50
3.7 nM
Compound: 2
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
[PMID: 37583818]
HGC-27 IC50
701 nM
Compound: 2
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
[PMID: 37583818]
MCF7 IC50
428 nM
Compound: 2
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
[PMID: 37583818]
MCF7 IC50
> 10000 nM
Compound: 2
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
[PMID: 37583818]
SK-MEL-2 IC50
143 nM
Compound: 2
Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
[PMID: 37583818]
SK-MEL-2 IC50
2812 nM
Compound: 2
Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
[PMID: 37583818]
SK-MEL-5 IC50
434 nM
Compound: 2
Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
[PMID: 37583818]
SK-MEL-5 IC50
6556 nM
Compound: 2
Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
[PMID: 37583818]
U-87MG ATCC IC50
3257 nM
Compound: 2
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
[PMID: 37583818]
U-87MG ATCC IC50
52 nM
Compound: 2
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
[PMID: 37583818]
In Vitro

PI3K-IN-41 (copound 2) (10 nM) decreases AKT phosphorylation in HGC-27 cells, and (1-10 μM) inhibits colony formation of HGC-27 cells, after exposure to UV light irradiation for 5 min, 15 min, and 30 min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K-IN-41 Related Antibodies
Molecular Weight

911.88

Formula

C45H39F2N5O12S
SMILES

COC1=CC(COC2=CC3=C(C=C(C(O3)=O)CN(S(C4=C(C=C(C=C4)F)F)(=O)=O)C5=C(N=CC(C6=CC7=C(N=CN=C7C(OC8CCOCC8)=C6)C)=C5)OC)C=C2)=C(C=C1OC)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3K-IN-41 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-41PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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PI3K-IN-41
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HY-155730
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