Hyaluronic acid Methacryloyl (MW 400 kDa)
Based on 1 Customer Validation
Hyaluronic acid Methacryloyl (MW 400 kDa) (HAMA (MW 400 kDa)) is a methacrylated hyaluronic acid with biocompatibility. Hyaluronic acid Methacryloyl (MW 400 kDa) also serves as a 3D printing hydrogel ink, featuring rapid photoresponsiveness, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl (MW 400 kDa) can rapidly initiate gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under ultraviolet irradiation. Moreover, the combination of Hyaluronic acid Methacryloyl with tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) acts as an important source material for organoid culture.
For research use only. We do not sell to patients.
- Molecular Weight:400000.00
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HAMA/pECM islet organoids (5% w/v HAMA, 10 mg/mL pECM) prepared via 3D printing using Hyaluronic acid Methacryloyl (MW 400 kDa) (5% w/v HAMA, 10 mg/mL pECM; 7 days) maintain higher viability, glucose-responsive insulin secretion levels, and endocrine protein expression of primary rat islets compared with 3D-printed pure HAMA organoids and unencapsulated islets[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 J (8-week-old, streptozotocin-induced Type 1 diabetes mellitus)[2]
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Dosage:5% (w/v) combined with 10 mg/mL pECM
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Administration:subcutaneous; single administration
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Result:Maintained blood glucose levels within the normal range for 90 days.
Returned blood glucose to <6.5 mmol/L within 60 min post-glucose stimulation in intraperitoneal glucose tolerance testing.
Reached postprandial serum insulin levels of 2.10 μg/L, close to normal mouse levels.
Showed an upward trend in body weight over the 90-day period.
Kept islets viable and expressing insulin/glucagon at 12 weeks post-transplantation.
Achieved a blood vessel density of 14% on the organoid surface, significantly higher than the 3D-printed HAMA-only organoid group.
Chemical Information
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Appearance Solid
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Molecular Weight 400000.00
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Color White to off-white
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SMILES
[Hyaluronic acid Methacryloyl (MW 400 kDa)]
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Synonyms
HAMA (MW 400 kDa)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hyaluronic acid Methacryloyl (MW 400 kDa) Related Classifications
HY-158220 Related Classifications
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- Hyaluronic acid Methacryloyl (MW 400 kDa)
- HAMA (MW 400 kDa)
- Biochemical Assay Reagents
- diabetic mice
- islet cell
- E. coli
- C57BL/6 J mice
- chondrogenic differentiation
- human mesenchymal stem cell
- Rac1/ROCK/MLCK signaling pathway
- pancreatic extracellular matrix
- type 1 diabetes mellitus
- primary rat islet
- Inhibitor
- inhibitor
- inhibit